Differential methylation in glucoregulatory genes of offspring born before vs. after maternal gastrointestinal bypass surgery

Obesity and overnutrition during pregnancy affect fetal programming of adult disease. Children born after maternal bariatric gastrointestinal bypass surgery (AMS) are less obese and exhibit improved cardiometabolic risk profiles carried into adulthood compared with siblings born before maternal surg...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-07, Vol.110 (28), p.11439-11444
Hauptverfasser:	Guénard, Frédéric, Deshaies, Yves, Cianflone, Katherine, Kral, John G., Marceau, Picard, Vohl, Marie-Claude
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological Sciences Body mass index Cardiology Child Cohort Studies Correlations DNA DNA Methylation Female Gastric Bypass Gene expression Gene Expression Profiling Genes Glucose Glucose - metabolism Heart surgery Humans Insulin Methylation Obesity Obesity - complications Obesity - genetics Obesity - surgery P values Pregnancy Pregnancy Complications - genetics Pregnancy Complications - surgery Siblings Type 2 diabetes mellitus
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