RNAi-mediated MMP-9 silencing inhibits mouse melanoma cell invasion and migration in vitro and in vivo

MMP‐9 participates in tumour growth, invasion, metastasis and vascularisation. Thus, inhibition of MMP‐9 may be involved in the process of tumourigenesis. We have investigated the effect of RNAi‐mediated MMP‐9 silencing on inhibiting invasion and migration of mouse melanoma cell B16. A specific and...

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Veröffentlicht in:	Cell biology international 2013-08, Vol.37 (8), p.849-854
Hauptverfasser:	Tang, Zhao-Yong, Liu, Yang, Liu, Long-Xing, Ding, Xiao-Yan, Zhang, Hong, Fang, Liao-Qiong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anti-cancer therapy Cell Movement Gene Knockdown Techniques invasion Lung Neoplasms - enzymology Lung Neoplasms - secondary Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism melanoma Melanoma, Experimental - enzymology Melanoma, Experimental - secondary metastasis Mice Mice, Inbred C57BL MMP-9 Neoplasm Invasiveness Neoplasm Transplantation RNA Interference RNA, Small Interfering - genetics siRNA Tumor Burden tumour growth
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