Alteration of a membrane associated marker in transplantable rat pancreatic acinar cell carcinoma
A monoclonal murine IgG has been developed which detects a cellular and intracytoplasmic membrane marker expressed only in the rat pancreatic acinar cell. Membrane aberrations in chemically induced transplantable rat pancreas acinar cell adenoma and carcinoma were examined using this IgG. The presen...
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| Veröffentlicht in: | Carcinogenesis (New York) 1984-06, Vol.5 (6), p.709-713 |
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| container_title | Carcinogenesis (New York) |
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| creator | Parsa, Ismail Reddy, Janardan K. |
| description | A monoclonal murine IgG has been developed which detects a cellular and intracytoplasmic membrane marker expressed only in the rat pancreatic acinar cell. Membrane aberrations in chemically induced transplantable rat pancreas acinar cell adenoma and carcinoma were examined using this IgG. The presence of this membrane marker was assessed by indirect immunofluorescence using paraffin sections of normal pancreas, acinar cell adenoma and transplanted tumors from rats and nude mice. The intracytoplasmic membrane of cells in acinar cell adenoma revealed a much higher intensity of fluorescence compared with normal acinar cells. In contrast there was an almost complete absence of fluorescent staining of the intracytoplasmic membranes of acinar cell carcinoma while their cell membranes showed an intensity of fluorescence far exceeding that of normal acinar cells. These findings suggest a defect in the dynamics of membrane-associated antigen(s) in these cancer cells. |
| doi_str_mv | 10.1093/carcin/5.6.709 |
| format | Article |
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Membrane aberrations in chemically induced transplantable rat pancreas acinar cell adenoma and carcinoma were examined using this IgG. The presence of this membrane marker was assessed by indirect immunofluorescence using paraffin sections of normal pancreas, acinar cell adenoma and transplanted tumors from rats and nude mice. The intracytoplasmic membrane of cells in acinar cell adenoma revealed a much higher intensity of fluorescence compared with normal acinar cells. In contrast there was an almost complete absence of fluorescent staining of the intracytoplasmic membranes of acinar cell carcinoma while their cell membranes showed an intensity of fluorescence far exceeding that of normal acinar cells. These findings suggest a defect in the dynamics of membrane-associated antigen(s) in these cancer cells.</description><identifier>ISSN: 0143-3334</identifier><identifier>EISSN: 1460-2180</identifier><identifier>DOI: 10.1093/carcin/5.6.709</identifier><identifier>PMID: 6373043</identifier><identifier>CODEN: CRNGDP</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adenoma - immunology ; Animals ; Antibodies, Monoclonal ; Antigens, Surface - analysis ; Biological and medical sciences ; carcinoma ; Carcinoma - immunology ; Cell Membrane - immunology ; Fluorescent Antibody Technique ; Gastroenterology. Liver. Pancreas. Abdomen ; Hybridomas - immunology ; Immunoglobulin G ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Medical sciences ; Mice ; Mice, Inbred BALB C ; monoclonal antibodies ; pancreas ; Pancreas - immunology ; Pancreatic Neoplasms - immunology ; Rats ; Tumors</subject><ispartof>Carcinogenesis (New York), 1984-06, Vol.5 (6), p.709-713</ispartof><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-d279ab1c8482181d8d9d3f65feda19fe134d9b98378e96ea80fcd292de152be13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27915,27916</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8857472$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6373043$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Parsa, Ismail</creatorcontrib><creatorcontrib>Reddy, Janardan K.</creatorcontrib><title>Alteration of a membrane associated marker in transplantable rat pancreatic acinar cell carcinoma</title><title>Carcinogenesis (New York)</title><addtitle>Carcinogenesis</addtitle><description>A monoclonal murine IgG has been developed which detects a cellular and intracytoplasmic membrane marker expressed only in the rat pancreatic acinar cell. Membrane aberrations in chemically induced transplantable rat pancreas acinar cell adenoma and carcinoma were examined using this IgG. The presence of this membrane marker was assessed by indirect immunofluorescence using paraffin sections of normal pancreas, acinar cell adenoma and transplanted tumors from rats and nude mice. The intracytoplasmic membrane of cells in acinar cell adenoma revealed a much higher intensity of fluorescence compared with normal acinar cells. In contrast there was an almost complete absence of fluorescent staining of the intracytoplasmic membranes of acinar cell carcinoma while their cell membranes showed an intensity of fluorescence far exceeding that of normal acinar cells. These findings suggest a defect in the dynamics of membrane-associated antigen(s) in these cancer cells.</description><subject>Adenoma - immunology</subject><subject>Animals</subject><subject>Antibodies, Monoclonal</subject><subject>Antigens, Surface - analysis</subject><subject>Biological and medical sciences</subject><subject>carcinoma</subject><subject>Carcinoma - immunology</subject><subject>Cell Membrane - immunology</subject><subject>Fluorescent Antibody Technique</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hybridomas - immunology</subject><subject>Immunoglobulin G</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>monoclonal antibodies</subject><subject>pancreas</subject><subject>Pancreas - immunology</subject><subject>Pancreatic Neoplasms - immunology</subject><subject>Rats</subject><subject>Tumors</subject><issn>0143-3334</issn><issn>1460-2180</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtLxDAUhYMoOj627oQsxF3HpLdpk6WKLxDcqIibcJvcQrWPMemA_nsjHWZ1F-c7h3MPY6dSLKUwcOkwuHa4VMtyWQmzwxayKEWWSy122ULIAjIAKA7YYYyfQsgSlNln-yVUIApYMLzqJgo4tePAx4Yj76mvAw7EMcbRtTiR5z2GLwq8HfiUpLjqcJiw7ognI1_h4AKlBMcxNcHAHXUdn3uNPR6zvQa7SCebe8Re725fbh6yp-f7x5urp8yB1lPm88pgLZ0udCovvfbGQ1OqhjxK05CEwpvaaKg0mZJQi8b53OSepMrrJB-xizl3FcbvNcXJ9m38r5KeGdfRSjAGlBQJXM6gC2OMgRq7Cm168ddKYf83tXN3q2xp06bJcLZJXtc9-S2-GTHp5xsdo8OuSRu5Nm4xrVVVVHnCshlr40Q_Wzlta8sKKmUf3j_sfSHli9Jv9hr-AP5ukLQ</recordid><startdate>198406</startdate><enddate>198406</enddate><creator>Parsa, Ismail</creator><creator>Reddy, Janardan K.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope></search><sort><creationdate>198406</creationdate><title>Alteration of a membrane associated marker in transplantable rat pancreatic acinar cell carcinoma</title><author>Parsa, Ismail ; Reddy, Janardan K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-d279ab1c8482181d8d9d3f65feda19fe134d9b98378e96ea80fcd292de152be13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Adenoma - immunology</topic><topic>Animals</topic><topic>Antibodies, Monoclonal</topic><topic>Antigens, Surface - analysis</topic><topic>Biological and medical sciences</topic><topic>carcinoma</topic><topic>Carcinoma - immunology</topic><topic>Cell Membrane - immunology</topic><topic>Fluorescent Antibody Technique</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Hybridomas - immunology</topic><topic>Immunoglobulin G</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>monoclonal antibodies</topic><topic>pancreas</topic><topic>Pancreas - immunology</topic><topic>Pancreatic Neoplasms - immunology</topic><topic>Rats</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Parsa, Ismail</creatorcontrib><creatorcontrib>Reddy, Janardan K.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Carcinogenesis (New York)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Parsa, Ismail</au><au>Reddy, Janardan K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alteration of a membrane associated marker in transplantable rat pancreatic acinar cell carcinoma</atitle><jtitle>Carcinogenesis (New York)</jtitle><addtitle>Carcinogenesis</addtitle><date>1984-06</date><risdate>1984</risdate><volume>5</volume><issue>6</issue><spage>709</spage><epage>713</epage><pages>709-713</pages><issn>0143-3334</issn><eissn>1460-2180</eissn><coden>CRNGDP</coden><abstract>A monoclonal murine IgG has been developed which detects a cellular and intracytoplasmic membrane marker expressed only in the rat pancreatic acinar cell. Membrane aberrations in chemically induced transplantable rat pancreas acinar cell adenoma and carcinoma were examined using this IgG. The presence of this membrane marker was assessed by indirect immunofluorescence using paraffin sections of normal pancreas, acinar cell adenoma and transplanted tumors from rats and nude mice. The intracytoplasmic membrane of cells in acinar cell adenoma revealed a much higher intensity of fluorescence compared with normal acinar cells. In contrast there was an almost complete absence of fluorescent staining of the intracytoplasmic membranes of acinar cell carcinoma while their cell membranes showed an intensity of fluorescence far exceeding that of normal acinar cells. These findings suggest a defect in the dynamics of membrane-associated antigen(s) in these cancer cells.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>6373043</pmid><doi>10.1093/carcin/5.6.709</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0143-3334 |
| ispartof | Carcinogenesis (New York), 1984-06, Vol.5 (6), p.709-713 |
| issn | 0143-3334 1460-2180 |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy |
| subjects | Adenoma - immunology Animals Antibodies, Monoclonal Antigens, Surface - analysis Biological and medical sciences carcinoma Carcinoma - immunology Cell Membrane - immunology Fluorescent Antibody Technique Gastroenterology. Liver. Pancreas. Abdomen Hybridomas - immunology Immunoglobulin G Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Mice Mice, Inbred BALB C monoclonal antibodies pancreas Pancreas - immunology Pancreatic Neoplasms - immunology Rats Tumors |
| title | Alteration of a membrane associated marker in transplantable rat pancreatic acinar cell carcinoma |
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