Anaplastic lymphoma kinase (ALK) gene rearrangement in non-small cell lung cancer (NSCLC): Results of a multi-centre ALK-testing

Abstract Background The reliable identification of non-small cell lung cancers (NSCLC) with chromosomal breaks in the gene of the anaplastic lymphoma kinase (ALK) is crucial for the induction of therapy with ALK-inhibitors. In order to ensure a reliable detection of ALK-breaks by means of fluorescen...

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Veröffentlicht in:	Lung cancer (Amsterdam, Netherlands) Netherlands), 2013-08, Vol.81 (2), p.200-206
Hauptverfasser:	v. Laffert, Maximilian, Warth, Arne, Penzel, Roland, Schirmacher, Peter, Jonigk, Danny, Kreipe, Hans, Schildhaus, Hans-Ulrich, Merkelbach-Bruse, Sabine, Büttner, Reinhard, Reu, Simone, Kerler, Rosi, Jung, Andreas, Kirchner, Thomas, Wölfel, Cornelius, Petersen, Iver, Rodriguez, Regulo, Jochum, Wolfram, Bartsch, Holger, Fisseler-Eckhoff, Annette, Berg, Erika, Lenze, Dido, Dietel, Manfred, Hummel, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Anaplastic lymphoma kinase (ALK) gene rearrangement Biological and medical sciences Carcinoma, Non-Small-Cell Lung - enzymology Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - pathology Fluorescence in situ hybridization (FISH) Gene Rearrangement Hematologic and hematopoietic diseases Hematology, Oncology and Palliative Medicine Humans Immunohistochemistry Immunohistochemistry (IHC) In Situ Hybridization, Fluorescence - methods Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lung Neoplasms - enzymology Lung Neoplasms - genetics Lung Neoplasms - pathology Medical sciences Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Non-small cell lung cancer (NSCLC) Pneumology Pulmonary/Respiratory Receptor Protein-Tyrosine Kinases - genetics Round robin test Tumors Tumors of the respiratory system and mediastinum
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