The effect of polaprezinc on gastric mucosal protection in rats with ethanol-induced gastric mucosal damage: Comparison study with rebamipide

Polaprezinc (PZ), which consists of l-carnosine and zinc, is widely used to treat gastric ulcers. We compared the effects of PZ with those of rebamipide (RM) on the expression of inflammatory cytokines, antioxidants, growth factors, and heat shock proteins (HSP) in a rat model. Seventy Sprague–Dawle...

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Veröffentlicht in:	Life sciences (1973) 2013-07, Vol.93 (2-3), p.69-77
Hauptverfasser:	Choi, Hyuk Soon, Lim, Ji-Youn, Chun, Hoon Jai, Lee, Min, Kim, Eun Sun, Keum, Bora, Seo, Yeon Seok, Jeen, Yoon-Tae, Um, Soon Ho, Lee, Hong Sik, Kim, Chang Duck, Ryu, Ho Sang, Sul, Donggeun
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine - analogs & derivatives Alanine - pharmacology animal models Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Anti-Ulcer Agents - pharmacology antioxidants Antioxidants - metabolism Carnosine Carnosine - analogs & derivatives Carnosine - pharmacology Cytokines - metabolism Disease Models, Animal Dose-Response Relationship, Drug Ethanol - adverse effects Gastric Mucosa - drug effects Gastric Mucosa - metabolism Gastric Mucosa - pathology Gastric ulcer glutathione transferase Glutathione Transferase - metabolism heat shock proteins Heat-Shock Proteins - metabolism heme oxygenase (biliverdin-producing) Heme Oxygenase-1 - metabolism interleukin-1beta interleukin-6 interleukin-8 Male mucosa necrosis nerve growth factor Organometallic Compounds - pharmacology Peroxiredoxins - metabolism Polaprezinc protective effect Quinolones - pharmacology Rats Rats, Sprague-Dawley Rebamipide Stomach Ulcer - metabolism Stomach Ulcer - pathology Stomach Ulcer - prevention & control superoxide dismutase Superoxide Dismutase - metabolism Superoxide Dismutase-1 tumor necrosis factor-alpha Vascular Endothelial Growth Factor A - metabolism vascular endothelial growth factors Western blotting Zinc Zinc Compounds - pharmacology
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