The effect of polaprezinc on gastric mucosal protection in rats with ethanol-induced gastric mucosal damage: Comparison study with rebamipide
Polaprezinc (PZ), which consists of l-carnosine and zinc, is widely used to treat gastric ulcers. We compared the effects of PZ with those of rebamipide (RM) on the expression of inflammatory cytokines, antioxidants, growth factors, and heat shock proteins (HSP) in a rat model. Seventy Sprague–Dawle...
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| Veröffentlicht in: | Life sciences (1973) 2013-07, Vol.93 (2-3), p.69-77 |
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| creator | Choi, Hyuk Soon Lim, Ji-Youn Chun, Hoon Jai Lee, Min Kim, Eun Sun Keum, Bora Seo, Yeon Seok Jeen, Yoon-Tae Um, Soon Ho Lee, Hong Sik Kim, Chang Duck Ryu, Ho Sang Sul, Donggeun |
| description | Polaprezinc (PZ), which consists of l-carnosine and zinc, is widely used to treat gastric ulcers. We compared the effects of PZ with those of rebamipide (RM) on the expression of inflammatory cytokines, antioxidants, growth factors, and heat shock proteins (HSP) in a rat model.
Seventy Sprague–Dawley rats were randomly assigned to test groups according to the dose of PZ at 5, 10, or 30mg/kg or RM at 10, 30, or 100mg/kg. Next, we obtained ulcer indices from rats with ethanol-induced gastric mucosal damage. Western blot analysis was used to evaluate the expression of various target proteins.
Pathological ulcer indices in the PZ and RM groups were significantly lower than those in the control group. The levels of inflammatory cytokines (interleukin 1β [IL-1β], IL-6, IL-8, and tumor necrosis factor α) decreased, whereas the levels of platelet-derived growth factor-B, vascular endothelial growth factor, and nerve growth factor significantly increased after PZ administration. Furthermore, the expression of antioxidants (superoxide dismutase 1 [SOD-1], SOD-2, heme oxygenase-1, glutathione S-transferase, peroxidredoxin-1, and peroxidredoxin-5) was significantly higher in the PZ group, and the levels of HSP 90, 70, 60, 47, 27, and 10 significantly increased with an increase in PZ dose.
In a rat model of ethanol-induced gastric mucosal damage, PZ administration ameliorated ethanol-induced mucosal injury and showed protective effects on the mucosa by reducing the levels of inflammatory cytokines and increasing the expression of antioxidant enzymes and growth factors. Furthermore, PZ showed cytoprotective effects by increasing the HSP levels. |
| doi_str_mv | 10.1016/j.lfs.2013.05.019 |
| format | Article |
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Seventy Sprague–Dawley rats were randomly assigned to test groups according to the dose of PZ at 5, 10, or 30mg/kg or RM at 10, 30, or 100mg/kg. Next, we obtained ulcer indices from rats with ethanol-induced gastric mucosal damage. Western blot analysis was used to evaluate the expression of various target proteins.
Pathological ulcer indices in the PZ and RM groups were significantly lower than those in the control group. The levels of inflammatory cytokines (interleukin 1β [IL-1β], IL-6, IL-8, and tumor necrosis factor α) decreased, whereas the levels of platelet-derived growth factor-B, vascular endothelial growth factor, and nerve growth factor significantly increased after PZ administration. Furthermore, the expression of antioxidants (superoxide dismutase 1 [SOD-1], SOD-2, heme oxygenase-1, glutathione S-transferase, peroxidredoxin-1, and peroxidredoxin-5) was significantly higher in the PZ group, and the levels of HSP 90, 70, 60, 47, 27, and 10 significantly increased with an increase in PZ dose.
In a rat model of ethanol-induced gastric mucosal damage, PZ administration ameliorated ethanol-induced mucosal injury and showed protective effects on the mucosa by reducing the levels of inflammatory cytokines and increasing the expression of antioxidant enzymes and growth factors. Furthermore, PZ showed cytoprotective effects by increasing the HSP levels.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/j.lfs.2013.05.019</identifier><identifier>PMID: 23743168</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Alanine - analogs & derivatives ; Alanine - pharmacology ; animal models ; Animals ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; Anti-Ulcer Agents - pharmacology ; antioxidants ; Antioxidants - metabolism ; Carnosine ; Carnosine - analogs & derivatives ; Carnosine - pharmacology ; Cytokines - metabolism ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Ethanol - adverse effects ; Gastric Mucosa - drug effects ; Gastric Mucosa - metabolism ; Gastric Mucosa - pathology ; Gastric ulcer ; glutathione transferase ; Glutathione Transferase - metabolism ; heat shock proteins ; Heat-Shock Proteins - metabolism ; heme oxygenase (biliverdin-producing) ; Heme Oxygenase-1 - metabolism ; interleukin-1beta ; interleukin-6 ; interleukin-8 ; Male ; mucosa ; necrosis ; nerve growth factor ; Organometallic Compounds - pharmacology ; Peroxiredoxins - metabolism ; Polaprezinc ; protective effect ; Quinolones - pharmacology ; Rats ; Rats, Sprague-Dawley ; Rebamipide ; Stomach Ulcer - metabolism ; Stomach Ulcer - pathology ; Stomach Ulcer - prevention & control ; superoxide dismutase ; Superoxide Dismutase - metabolism ; Superoxide Dismutase-1 ; tumor necrosis factor-alpha ; Vascular Endothelial Growth Factor A - metabolism ; vascular endothelial growth factors ; Western blotting ; Zinc ; Zinc Compounds - pharmacology</subject><ispartof>Life sciences (1973), 2013-07, Vol.93 (2-3), p.69-77</ispartof><rights>2013</rights><rights>Copyright © 2013. Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-137a590b2f9887af5cd3e8cf53bde789284681371085836490c63f03544a259c3</citedby><cites>FETCH-LOGICAL-c377t-137a590b2f9887af5cd3e8cf53bde789284681371085836490c63f03544a259c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0024320513002968$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23743168$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Choi, Hyuk Soon</creatorcontrib><creatorcontrib>Lim, Ji-Youn</creatorcontrib><creatorcontrib>Chun, Hoon Jai</creatorcontrib><creatorcontrib>Lee, Min</creatorcontrib><creatorcontrib>Kim, Eun Sun</creatorcontrib><creatorcontrib>Keum, Bora</creatorcontrib><creatorcontrib>Seo, Yeon Seok</creatorcontrib><creatorcontrib>Jeen, Yoon-Tae</creatorcontrib><creatorcontrib>Um, Soon Ho</creatorcontrib><creatorcontrib>Lee, Hong Sik</creatorcontrib><creatorcontrib>Kim, Chang Duck</creatorcontrib><creatorcontrib>Ryu, Ho Sang</creatorcontrib><creatorcontrib>Sul, Donggeun</creatorcontrib><title>The effect of polaprezinc on gastric mucosal protection in rats with ethanol-induced gastric mucosal damage: Comparison study with rebamipide</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>Polaprezinc (PZ), which consists of l-carnosine and zinc, is widely used to treat gastric ulcers. We compared the effects of PZ with those of rebamipide (RM) on the expression of inflammatory cytokines, antioxidants, growth factors, and heat shock proteins (HSP) in a rat model.
Seventy Sprague–Dawley rats were randomly assigned to test groups according to the dose of PZ at 5, 10, or 30mg/kg or RM at 10, 30, or 100mg/kg. Next, we obtained ulcer indices from rats with ethanol-induced gastric mucosal damage. Western blot analysis was used to evaluate the expression of various target proteins.
Pathological ulcer indices in the PZ and RM groups were significantly lower than those in the control group. The levels of inflammatory cytokines (interleukin 1β [IL-1β], IL-6, IL-8, and tumor necrosis factor α) decreased, whereas the levels of platelet-derived growth factor-B, vascular endothelial growth factor, and nerve growth factor significantly increased after PZ administration. Furthermore, the expression of antioxidants (superoxide dismutase 1 [SOD-1], SOD-2, heme oxygenase-1, glutathione S-transferase, peroxidredoxin-1, and peroxidredoxin-5) was significantly higher in the PZ group, and the levels of HSP 90, 70, 60, 47, 27, and 10 significantly increased with an increase in PZ dose.
In a rat model of ethanol-induced gastric mucosal damage, PZ administration ameliorated ethanol-induced mucosal injury and showed protective effects on the mucosa by reducing the levels of inflammatory cytokines and increasing the expression of antioxidant enzymes and growth factors. Furthermore, PZ showed cytoprotective effects by increasing the HSP levels.</description><subject>Alanine - analogs & derivatives</subject><subject>Alanine - pharmacology</subject><subject>animal models</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</subject><subject>Anti-Ulcer Agents - pharmacology</subject><subject>antioxidants</subject><subject>Antioxidants - metabolism</subject><subject>Carnosine</subject><subject>Carnosine - analogs & derivatives</subject><subject>Carnosine - pharmacology</subject><subject>Cytokines - metabolism</subject><subject>Disease Models, Animal</subject><subject>Dose-Response Relationship, Drug</subject><subject>Ethanol - adverse effects</subject><subject>Gastric Mucosa - drug effects</subject><subject>Gastric Mucosa - metabolism</subject><subject>Gastric Mucosa - pathology</subject><subject>Gastric ulcer</subject><subject>glutathione transferase</subject><subject>Glutathione Transferase - metabolism</subject><subject>heat shock proteins</subject><subject>Heat-Shock Proteins - metabolism</subject><subject>heme oxygenase (biliverdin-producing)</subject><subject>Heme Oxygenase-1 - metabolism</subject><subject>interleukin-1beta</subject><subject>interleukin-6</subject><subject>interleukin-8</subject><subject>Male</subject><subject>mucosa</subject><subject>necrosis</subject><subject>nerve growth factor</subject><subject>Organometallic Compounds - pharmacology</subject><subject>Peroxiredoxins - metabolism</subject><subject>Polaprezinc</subject><subject>protective effect</subject><subject>Quinolones - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Rebamipide</subject><subject>Stomach Ulcer - metabolism</subject><subject>Stomach Ulcer - pathology</subject><subject>Stomach Ulcer - prevention & control</subject><subject>superoxide dismutase</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Superoxide Dismutase-1</subject><subject>tumor necrosis factor-alpha</subject><subject>Vascular Endothelial Growth Factor A - metabolism</subject><subject>vascular endothelial growth factors</subject><subject>Western blotting</subject><subject>Zinc</subject><subject>Zinc Compounds - pharmacology</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc2O1SAYhonROMfRC3CjLN20fpTSgq7MiX_JJC6cWRMO_TiHk7ZUoJrxHrxnmXR0Y-KKBc_zBt6XkOcMagase32uR5fqBhivQdTA1AOyY7JXFXScPSQ7gKateAPigjxJ6QwAQvT8MbloeN9y1skd-XV9QorOoc00OLqE0SwRf_rZ0jDTo0k5ekun1YZkRrrEkAvpy5WfaTQ50R8-nyjmk5nDWPl5WC0O_3iDmcwR39B9mBYTfSp-yutwu9kRD2byix_wKXnkzJjw2f15SW4-vL_ef6quvnz8vH93VVne97livDdCwaFxSsreOGEHjtI6wQ8D9lI1su1kgRhIIXnXKrAdd8BF25pGKMsvyastt3zo24op68kni-NoZgxr0owrBaUqzgrKNtTGkFJEp5foJxNvNQN9t4I-67KCvltBg9BlheK8uI9fDxMOf40_tRfg5QY4E7Q5lkb0zdeSIKAEyr7jhXi7EVhq-O4x6mQ9zqVcH8sCegj-Pw_4DbE9osQ</recordid><startdate>20130730</startdate><enddate>20130730</enddate><creator>Choi, Hyuk Soon</creator><creator>Lim, Ji-Youn</creator><creator>Chun, Hoon Jai</creator><creator>Lee, Min</creator><creator>Kim, Eun Sun</creator><creator>Keum, Bora</creator><creator>Seo, Yeon Seok</creator><creator>Jeen, Yoon-Tae</creator><creator>Um, Soon Ho</creator><creator>Lee, Hong Sik</creator><creator>Kim, Chang Duck</creator><creator>Ryu, Ho Sang</creator><creator>Sul, Donggeun</creator><general>Elsevier Inc</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130730</creationdate><title>The effect of polaprezinc on gastric mucosal protection in rats with ethanol-induced gastric mucosal damage: Comparison study with rebamipide</title><author>Choi, Hyuk Soon ; Lim, Ji-Youn ; Chun, Hoon Jai ; Lee, Min ; Kim, Eun Sun ; Keum, Bora ; Seo, Yeon Seok ; Jeen, Yoon-Tae ; Um, Soon Ho ; Lee, Hong Sik ; Kim, Chang Duck ; Ryu, Ho Sang ; Sul, Donggeun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-137a590b2f9887af5cd3e8cf53bde789284681371085836490c63f03544a259c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Alanine - analogs & derivatives</topic><topic>Alanine - pharmacology</topic><topic>animal models</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</topic><topic>Anti-Ulcer Agents - pharmacology</topic><topic>antioxidants</topic><topic>Antioxidants - metabolism</topic><topic>Carnosine</topic><topic>Carnosine - analogs & derivatives</topic><topic>Carnosine - pharmacology</topic><topic>Cytokines - metabolism</topic><topic>Disease Models, Animal</topic><topic>Dose-Response Relationship, Drug</topic><topic>Ethanol - adverse effects</topic><topic>Gastric Mucosa - drug effects</topic><topic>Gastric Mucosa - metabolism</topic><topic>Gastric Mucosa - pathology</topic><topic>Gastric ulcer</topic><topic>glutathione transferase</topic><topic>Glutathione Transferase - metabolism</topic><topic>heat shock proteins</topic><topic>Heat-Shock Proteins - metabolism</topic><topic>heme oxygenase (biliverdin-producing)</topic><topic>Heme Oxygenase-1 - metabolism</topic><topic>interleukin-1beta</topic><topic>interleukin-6</topic><topic>interleukin-8</topic><topic>Male</topic><topic>mucosa</topic><topic>necrosis</topic><topic>nerve growth factor</topic><topic>Organometallic Compounds - pharmacology</topic><topic>Peroxiredoxins - metabolism</topic><topic>Polaprezinc</topic><topic>protective effect</topic><topic>Quinolones - pharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Rebamipide</topic><topic>Stomach Ulcer - metabolism</topic><topic>Stomach Ulcer - pathology</topic><topic>Stomach Ulcer - prevention & control</topic><topic>superoxide dismutase</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Superoxide Dismutase-1</topic><topic>tumor necrosis factor-alpha</topic><topic>Vascular Endothelial Growth Factor A - metabolism</topic><topic>vascular endothelial growth factors</topic><topic>Western blotting</topic><topic>Zinc</topic><topic>Zinc Compounds - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Choi, Hyuk Soon</creatorcontrib><creatorcontrib>Lim, Ji-Youn</creatorcontrib><creatorcontrib>Chun, Hoon Jai</creatorcontrib><creatorcontrib>Lee, Min</creatorcontrib><creatorcontrib>Kim, Eun Sun</creatorcontrib><creatorcontrib>Keum, Bora</creatorcontrib><creatorcontrib>Seo, Yeon Seok</creatorcontrib><creatorcontrib>Jeen, Yoon-Tae</creatorcontrib><creatorcontrib>Um, Soon Ho</creatorcontrib><creatorcontrib>Lee, Hong Sik</creatorcontrib><creatorcontrib>Kim, Chang Duck</creatorcontrib><creatorcontrib>Ryu, Ho Sang</creatorcontrib><creatorcontrib>Sul, Donggeun</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Choi, Hyuk Soon</au><au>Lim, Ji-Youn</au><au>Chun, Hoon Jai</au><au>Lee, Min</au><au>Kim, Eun Sun</au><au>Keum, Bora</au><au>Seo, Yeon Seok</au><au>Jeen, Yoon-Tae</au><au>Um, Soon Ho</au><au>Lee, Hong Sik</au><au>Kim, Chang Duck</au><au>Ryu, Ho Sang</au><au>Sul, Donggeun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of polaprezinc on gastric mucosal protection in rats with ethanol-induced gastric mucosal damage: Comparison study with rebamipide</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>2013-07-30</date><risdate>2013</risdate><volume>93</volume><issue>2-3</issue><spage>69</spage><epage>77</epage><pages>69-77</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>Polaprezinc (PZ), which consists of l-carnosine and zinc, is widely used to treat gastric ulcers. We compared the effects of PZ with those of rebamipide (RM) on the expression of inflammatory cytokines, antioxidants, growth factors, and heat shock proteins (HSP) in a rat model.
Seventy Sprague–Dawley rats were randomly assigned to test groups according to the dose of PZ at 5, 10, or 30mg/kg or RM at 10, 30, or 100mg/kg. Next, we obtained ulcer indices from rats with ethanol-induced gastric mucosal damage. Western blot analysis was used to evaluate the expression of various target proteins.
Pathological ulcer indices in the PZ and RM groups were significantly lower than those in the control group. The levels of inflammatory cytokines (interleukin 1β [IL-1β], IL-6, IL-8, and tumor necrosis factor α) decreased, whereas the levels of platelet-derived growth factor-B, vascular endothelial growth factor, and nerve growth factor significantly increased after PZ administration. Furthermore, the expression of antioxidants (superoxide dismutase 1 [SOD-1], SOD-2, heme oxygenase-1, glutathione S-transferase, peroxidredoxin-1, and peroxidredoxin-5) was significantly higher in the PZ group, and the levels of HSP 90, 70, 60, 47, 27, and 10 significantly increased with an increase in PZ dose.
In a rat model of ethanol-induced gastric mucosal damage, PZ administration ameliorated ethanol-induced mucosal injury and showed protective effects on the mucosa by reducing the levels of inflammatory cytokines and increasing the expression of antioxidant enzymes and growth factors. Furthermore, PZ showed cytoprotective effects by increasing the HSP levels.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>23743168</pmid><doi>10.1016/j.lfs.2013.05.019</doi><tpages>9</tpages></addata></record> |
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| ispartof | Life sciences (1973), 2013-07, Vol.93 (2-3), p.69-77 |
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| subjects | Alanine - analogs & derivatives Alanine - pharmacology animal models Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Anti-Ulcer Agents - pharmacology antioxidants Antioxidants - metabolism Carnosine Carnosine - analogs & derivatives Carnosine - pharmacology Cytokines - metabolism Disease Models, Animal Dose-Response Relationship, Drug Ethanol - adverse effects Gastric Mucosa - drug effects Gastric Mucosa - metabolism Gastric Mucosa - pathology Gastric ulcer glutathione transferase Glutathione Transferase - metabolism heat shock proteins Heat-Shock Proteins - metabolism heme oxygenase (biliverdin-producing) Heme Oxygenase-1 - metabolism interleukin-1beta interleukin-6 interleukin-8 Male mucosa necrosis nerve growth factor Organometallic Compounds - pharmacology Peroxiredoxins - metabolism Polaprezinc protective effect Quinolones - pharmacology Rats Rats, Sprague-Dawley Rebamipide Stomach Ulcer - metabolism Stomach Ulcer - pathology Stomach Ulcer - prevention & control superoxide dismutase Superoxide Dismutase - metabolism Superoxide Dismutase-1 tumor necrosis factor-alpha Vascular Endothelial Growth Factor A - metabolism vascular endothelial growth factors Western blotting Zinc Zinc Compounds - pharmacology |
| title | The effect of polaprezinc on gastric mucosal protection in rats with ethanol-induced gastric mucosal damage: Comparison study with rebamipide |
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