Low Hemoglobin Levels and Recurrent Falls in U.S. Men and Women: Prospective Findings from the REasons for Geographic And Racial Differences in Stroke (REGARDS) Cohort
Abstract Background There are few data available on low hemoglobin and incident falls in the general U.S. population. Methods Of 30,239 black and white U.S. adults ≥45 years in the population-based REasons for Geographic And Racial Differences in Stroke study, 16,782 had hemoglobin measured at basel...
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| Veröffentlicht in: | The American journal of the medical sciences 2013-06, Vol.345 (6), p.446-454 |
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| creator | Barrett Bowling, C., MD Brown, Cynthia J., MD, MSPH Allman, Richard M., MD Warriner, Amy H., MD Curtis, Jeffrey R., MD, MS, MPH Warnock, David G., MD Muntner, Paul, PhD Bradbury, Brian D., MA, DSc Kilpatrick, Ryan D., PhD Isitt, John J., MS Judd, Suzanne, PhD McClellan, William, MD, MPH |
| description | Abstract Background There are few data available on low hemoglobin and incident falls in the general U.S. population. Methods Of 30,239 black and white U.S. adults ≥45 years in the population-based REasons for Geographic And Racial Differences in Stroke study, 16,782 had hemoglobin measured at baseline and follow-up data on falls. Hemoglobin was categorized by 1.0 g/dL increments relative to the World Health Organization anemia threshold ( |
| doi_str_mv | 10.1097/MAJ.0b013e3182638364 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1399054283</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0002962915306339</els_id><sourcerecordid>1399054283</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5124-13013b71430bbb1006a4477a27e2339e00c9141f743e4aab68ce018f7b71e0623</originalsourceid><addsrcrecordid>eNqVUk1vEzEUXCEQDYV_gJCP5bCpPzb7wQEpSpO0KBUooeJoeb1vs268dmrvJuov4m_ibQoHLoiTpfdm5skzE0XvCR4TXGSXt9MvY1xiwoCRnKYsZ2nyIhqRCctjWhT4ZTTCGNO4SGlxFr3x_h5jQnPCXkdnlDGa54yOop8re0TX0NqttqUyaAUH0B4JU6E1yN45MB1aCB1mYXs33ozRLZin_Q_bgvmEvjnr9yA7dQC0UKZSZutR7WyLugbQei68NWFgHVqC3Tqxb5RE00FfSCU0ulJ1DeGMhKcTm87ZHaCL9Xw5XV9tPqKZbazr3kavaqE9vHt-z6O7xfz77DpefV3ezKarWE4ITWLCgiFlRhKGy7IkGKciSbJM0AzCnwvAWBYkIXWWMEiEKNNcAiZ5nQUO4JSy8-jipLt39qEH3_FWeQlaCwO295ywYO0koTkL0OQElcEB76Dme6da4R45wXyIiIeI-N8RBdqH5wt92UL1h_Q7kwDIT4Cj1R04v9P9ERxvQOiu-Zf25xM1ZAgHFVheqsHaSrkQEa-s-l8BqZVRUugdPIK_t70zwX5OuKcc883QsKFgoXU4DQazXyhKxZY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1399054283</pqid></control><display><type>article</type><title>Low Hemoglobin Levels and Recurrent Falls in U.S. Men and Women: Prospective Findings from the REasons for Geographic And Racial Differences in Stroke (REGARDS) Cohort</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><source>Alma/SFX Local Collection</source><creator>Barrett Bowling, C., MD ; Brown, Cynthia J., MD, MSPH ; Allman, Richard M., MD ; Warriner, Amy H., MD ; Curtis, Jeffrey R., MD, MS, MPH ; Warnock, David G., MD ; Muntner, Paul, PhD ; Bradbury, Brian D., MA, DSc ; Kilpatrick, Ryan D., PhD ; Isitt, John J., MS ; Judd, Suzanne, PhD ; McClellan, William, MD, MPH</creator><creatorcontrib>Barrett Bowling, C., MD ; Brown, Cynthia J., MD, MSPH ; Allman, Richard M., MD ; Warriner, Amy H., MD ; Curtis, Jeffrey R., MD, MS, MPH ; Warnock, David G., MD ; Muntner, Paul, PhD ; Bradbury, Brian D., MA, DSc ; Kilpatrick, Ryan D., PhD ; Isitt, John J., MS ; Judd, Suzanne, PhD ; McClellan, William, MD, MPH</creatorcontrib><description>Abstract Background There are few data available on low hemoglobin and incident falls in the general U.S. population. Methods Of 30,239 black and white U.S. adults ≥45 years in the population-based REasons for Geographic And Racial Differences in Stroke study, 16,782 had hemoglobin measured at baseline and follow-up data on falls. Hemoglobin was categorized by 1.0 g/dL increments relative to the World Health Organization anemia threshold (<13.0 g/dL for men, <12.0 g/dL for women). Recurrent falls (≥2 falls in the 6 months after baseline) were assessed during a telephone interview. Results Recurrent falls occurred in 3.9% of men and 4.8% of women. Compared with those with a hemoglobin level 1 to 2 g/dL above the anemia cut-off, multivariable adjusted odds ratios (95% confidence intervals) for recurrent falls associated with hemoglobin levels ≥3, 2 to <3 and 0 to 1 g/dL above the cut-off point, and 0 to <1 and ≥1 g/dL below the cut-off point were 0.73 (0.45–1.19), 0.84 (0.57–1.24), 1.29 (0.88–1.90), 1.32 (0.0.80–1.2.18) and 2.12 (1.23–3.63), respectively, among men (linear trend P < 0.001), and 1.59 (1.10–2.3), 1.24 (0.95–1.62), 1.42(1.11–1.81), 1.28 (0.91–1.80) and 1.76 (1.13–2.74), respectively, among women (linear trend P = 0.45; quadratic trend P = 0.016). Conclusions Among men, lower hemoglobin levels were associated with an increased risk for recurrent falls. Although our findings suggest an increased risk for recurrent falls at both lower and higher hemoglobin levels among women, these findings should be confirmed in subsequent studies.</description><identifier>ISSN: 0002-9629</identifier><identifier>ISSN: 1538-2990</identifier><identifier>EISSN: 1538-2990</identifier><identifier>DOI: 10.1097/MAJ.0b013e3182638364</identifier><identifier>PMID: 23328832</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Accidental Falls - statistics & numerical data ; Aged ; Anemia - blood ; Anemia - complications ; Black or African American ; Black People ; Cohort Studies ; Falls ; Female ; Gender ; Hemoglobin ; Hemoglobins - metabolism ; Humans ; Internal Medicine ; Male ; Middle Aged ; Prospective Studies ; Recurrence ; Risk Factors ; Sex Factors ; Stroke ; United States ; White People</subject><ispartof>The American journal of the medical sciences, 2013-06, Vol.345 (6), p.446-454</ispartof><rights>Southern Society for Clinical Investigation</rights><rights>2013 Southern Society for Clinical Investigation</rights><rights>Copyright 2013 Southern Society for Clinical Investigation</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5124-13013b71430bbb1006a4477a27e2339e00c9141f743e4aab68ce018f7b71e0623</citedby><cites>FETCH-LOGICAL-c5124-13013b71430bbb1006a4477a27e2339e00c9141f743e4aab68ce018f7b71e0623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23328832$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barrett Bowling, C., MD</creatorcontrib><creatorcontrib>Brown, Cynthia J., MD, MSPH</creatorcontrib><creatorcontrib>Allman, Richard M., MD</creatorcontrib><creatorcontrib>Warriner, Amy H., MD</creatorcontrib><creatorcontrib>Curtis, Jeffrey R., MD, MS, MPH</creatorcontrib><creatorcontrib>Warnock, David G., MD</creatorcontrib><creatorcontrib>Muntner, Paul, PhD</creatorcontrib><creatorcontrib>Bradbury, Brian D., MA, DSc</creatorcontrib><creatorcontrib>Kilpatrick, Ryan D., PhD</creatorcontrib><creatorcontrib>Isitt, John J., MS</creatorcontrib><creatorcontrib>Judd, Suzanne, PhD</creatorcontrib><creatorcontrib>McClellan, William, MD, MPH</creatorcontrib><title>Low Hemoglobin Levels and Recurrent Falls in U.S. Men and Women: Prospective Findings from the REasons for Geographic And Racial Differences in Stroke (REGARDS) Cohort</title><title>The American journal of the medical sciences</title><addtitle>Am J Med Sci</addtitle><description>Abstract Background There are few data available on low hemoglobin and incident falls in the general U.S. population. Methods Of 30,239 black and white U.S. adults ≥45 years in the population-based REasons for Geographic And Racial Differences in Stroke study, 16,782 had hemoglobin measured at baseline and follow-up data on falls. Hemoglobin was categorized by 1.0 g/dL increments relative to the World Health Organization anemia threshold (<13.0 g/dL for men, <12.0 g/dL for women). Recurrent falls (≥2 falls in the 6 months after baseline) were assessed during a telephone interview. Results Recurrent falls occurred in 3.9% of men and 4.8% of women. Compared with those with a hemoglobin level 1 to 2 g/dL above the anemia cut-off, multivariable adjusted odds ratios (95% confidence intervals) for recurrent falls associated with hemoglobin levels ≥3, 2 to <3 and 0 to 1 g/dL above the cut-off point, and 0 to <1 and ≥1 g/dL below the cut-off point were 0.73 (0.45–1.19), 0.84 (0.57–1.24), 1.29 (0.88–1.90), 1.32 (0.0.80–1.2.18) and 2.12 (1.23–3.63), respectively, among men (linear trend P < 0.001), and 1.59 (1.10–2.3), 1.24 (0.95–1.62), 1.42(1.11–1.81), 1.28 (0.91–1.80) and 1.76 (1.13–2.74), respectively, among women (linear trend P = 0.45; quadratic trend P = 0.016). Conclusions Among men, lower hemoglobin levels were associated with an increased risk for recurrent falls. Although our findings suggest an increased risk for recurrent falls at both lower and higher hemoglobin levels among women, these findings should be confirmed in subsequent studies.</description><subject>Accidental Falls - statistics & numerical data</subject><subject>Aged</subject><subject>Anemia - blood</subject><subject>Anemia - complications</subject><subject>Black or African American</subject><subject>Black People</subject><subject>Cohort Studies</subject><subject>Falls</subject><subject>Female</subject><subject>Gender</subject><subject>Hemoglobin</subject><subject>Hemoglobins - metabolism</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>Recurrence</subject><subject>Risk Factors</subject><subject>Sex Factors</subject><subject>Stroke</subject><subject>United States</subject><subject>White People</subject><issn>0002-9629</issn><issn>1538-2990</issn><issn>1538-2990</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVUk1vEzEUXCEQDYV_gJCP5bCpPzb7wQEpSpO0KBUooeJoeb1vs268dmrvJuov4m_ibQoHLoiTpfdm5skzE0XvCR4TXGSXt9MvY1xiwoCRnKYsZ2nyIhqRCctjWhT4ZTTCGNO4SGlxFr3x_h5jQnPCXkdnlDGa54yOop8re0TX0NqttqUyaAUH0B4JU6E1yN45MB1aCB1mYXs33ozRLZin_Q_bgvmEvjnr9yA7dQC0UKZSZutR7WyLugbQei68NWFgHVqC3Tqxb5RE00FfSCU0ulJ1DeGMhKcTm87ZHaCL9Xw5XV9tPqKZbazr3kavaqE9vHt-z6O7xfz77DpefV3ezKarWE4ITWLCgiFlRhKGy7IkGKciSbJM0AzCnwvAWBYkIXWWMEiEKNNcAiZ5nQUO4JSy8-jipLt39qEH3_FWeQlaCwO295ywYO0koTkL0OQElcEB76Dme6da4R45wXyIiIeI-N8RBdqH5wt92UL1h_Q7kwDIT4Cj1R04v9P9ERxvQOiu-Zf25xM1ZAgHFVheqsHaSrkQEa-s-l8BqZVRUugdPIK_t70zwX5OuKcc883QsKFgoXU4DQazXyhKxZY</recordid><startdate>201306</startdate><enddate>201306</enddate><creator>Barrett Bowling, C., MD</creator><creator>Brown, Cynthia J., MD, MSPH</creator><creator>Allman, Richard M., MD</creator><creator>Warriner, Amy H., MD</creator><creator>Curtis, Jeffrey R., MD, MS, MPH</creator><creator>Warnock, David G., MD</creator><creator>Muntner, Paul, PhD</creator><creator>Bradbury, Brian D., MA, DSc</creator><creator>Kilpatrick, Ryan D., PhD</creator><creator>Isitt, John J., MS</creator><creator>Judd, Suzanne, PhD</creator><creator>McClellan, William, MD, MPH</creator><general>Elsevier Inc</general><general>Copyright Southern Society for Clinical Investigation</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201306</creationdate><title>Low Hemoglobin Levels and Recurrent Falls in U.S. Men and Women: Prospective Findings from the REasons for Geographic And Racial Differences in Stroke (REGARDS) Cohort</title><author>Barrett Bowling, C., MD ; Brown, Cynthia J., MD, MSPH ; Allman, Richard M., MD ; Warriner, Amy H., MD ; Curtis, Jeffrey R., MD, MS, MPH ; Warnock, David G., MD ; Muntner, Paul, PhD ; Bradbury, Brian D., MA, DSc ; Kilpatrick, Ryan D., PhD ; Isitt, John J., MS ; Judd, Suzanne, PhD ; McClellan, William, MD, MPH</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5124-13013b71430bbb1006a4477a27e2339e00c9141f743e4aab68ce018f7b71e0623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Accidental Falls - statistics & numerical data</topic><topic>Aged</topic><topic>Anemia - blood</topic><topic>Anemia - complications</topic><topic>Black or African American</topic><topic>Black People</topic><topic>Cohort Studies</topic><topic>Falls</topic><topic>Female</topic><topic>Gender</topic><topic>Hemoglobin</topic><topic>Hemoglobins - metabolism</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prospective Studies</topic><topic>Recurrence</topic><topic>Risk Factors</topic><topic>Sex Factors</topic><topic>Stroke</topic><topic>United States</topic><topic>White People</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barrett Bowling, C., MD</creatorcontrib><creatorcontrib>Brown, Cynthia J., MD, MSPH</creatorcontrib><creatorcontrib>Allman, Richard M., MD</creatorcontrib><creatorcontrib>Warriner, Amy H., MD</creatorcontrib><creatorcontrib>Curtis, Jeffrey R., MD, MS, MPH</creatorcontrib><creatorcontrib>Warnock, David G., MD</creatorcontrib><creatorcontrib>Muntner, Paul, PhD</creatorcontrib><creatorcontrib>Bradbury, Brian D., MA, DSc</creatorcontrib><creatorcontrib>Kilpatrick, Ryan D., PhD</creatorcontrib><creatorcontrib>Isitt, John J., MS</creatorcontrib><creatorcontrib>Judd, Suzanne, PhD</creatorcontrib><creatorcontrib>McClellan, William, MD, MPH</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of the medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barrett Bowling, C., MD</au><au>Brown, Cynthia J., MD, MSPH</au><au>Allman, Richard M., MD</au><au>Warriner, Amy H., MD</au><au>Curtis, Jeffrey R., MD, MS, MPH</au><au>Warnock, David G., MD</au><au>Muntner, Paul, PhD</au><au>Bradbury, Brian D., MA, DSc</au><au>Kilpatrick, Ryan D., PhD</au><au>Isitt, John J., MS</au><au>Judd, Suzanne, PhD</au><au>McClellan, William, MD, MPH</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low Hemoglobin Levels and Recurrent Falls in U.S. Men and Women: Prospective Findings from the REasons for Geographic And Racial Differences in Stroke (REGARDS) Cohort</atitle><jtitle>The American journal of the medical sciences</jtitle><addtitle>Am J Med Sci</addtitle><date>2013-06</date><risdate>2013</risdate><volume>345</volume><issue>6</issue><spage>446</spage><epage>454</epage><pages>446-454</pages><issn>0002-9629</issn><issn>1538-2990</issn><eissn>1538-2990</eissn><abstract>Abstract Background There are few data available on low hemoglobin and incident falls in the general U.S. population. Methods Of 30,239 black and white U.S. adults ≥45 years in the population-based REasons for Geographic And Racial Differences in Stroke study, 16,782 had hemoglobin measured at baseline and follow-up data on falls. Hemoglobin was categorized by 1.0 g/dL increments relative to the World Health Organization anemia threshold (<13.0 g/dL for men, <12.0 g/dL for women). Recurrent falls (≥2 falls in the 6 months after baseline) were assessed during a telephone interview. Results Recurrent falls occurred in 3.9% of men and 4.8% of women. Compared with those with a hemoglobin level 1 to 2 g/dL above the anemia cut-off, multivariable adjusted odds ratios (95% confidence intervals) for recurrent falls associated with hemoglobin levels ≥3, 2 to <3 and 0 to 1 g/dL above the cut-off point, and 0 to <1 and ≥1 g/dL below the cut-off point were 0.73 (0.45–1.19), 0.84 (0.57–1.24), 1.29 (0.88–1.90), 1.32 (0.0.80–1.2.18) and 2.12 (1.23–3.63), respectively, among men (linear trend P < 0.001), and 1.59 (1.10–2.3), 1.24 (0.95–1.62), 1.42(1.11–1.81), 1.28 (0.91–1.80) and 1.76 (1.13–2.74), respectively, among women (linear trend P = 0.45; quadratic trend P = 0.016). Conclusions Among men, lower hemoglobin levels were associated with an increased risk for recurrent falls. Although our findings suggest an increased risk for recurrent falls at both lower and higher hemoglobin levels among women, these findings should be confirmed in subsequent studies.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>23328832</pmid><doi>10.1097/MAJ.0b013e3182638364</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Accidental Falls - statistics & numerical data Aged Anemia - blood Anemia - complications Black or African American Black People Cohort Studies Falls Female Gender Hemoglobin Hemoglobins - metabolism Humans Internal Medicine Male Middle Aged Prospective Studies Recurrence Risk Factors Sex Factors Stroke United States White People |
| title | Low Hemoglobin Levels and Recurrent Falls in U.S. Men and Women: Prospective Findings from the REasons for Geographic And Racial Differences in Stroke (REGARDS) Cohort |
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