Characterization of xanthatin: Anticancer properties and mechanisms of inhibited murine melanoma in vitro and in vivo
Anti-cancer investigations on Xanthatin mainly focus on in vitro experiments. We herein reported the anti-tumor effects of Xanthatin both in vitro and in vivo. MTS assay results showed that Xanthatin had a remarkable anti-proliferative effect on B16-F10 cells. Moreover, the expression of β-catenin w...
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| Veröffentlicht in: | Phytomedicine (Stuttgart) 2013-07, Vol.20 (10), p.865-873 |
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| creator | Li, Wei D. Wu, Yu Zhang, Lei Yan, Ling G. Yin, Fang Z. Ruan, Jun S. Chen, Zhi P. Yang, Guang M. Yan, Cui P. Zhao, Ding Lu, Yin Cai, Bao C. |
| description | Anti-cancer investigations on Xanthatin mainly focus on in vitro experiments. We herein reported the anti-tumor effects of Xanthatin both in vitro and in vivo. MTS assay results showed that Xanthatin had a remarkable anti-proliferative effect on B16-F10 cells. Moreover, the expression of β-catenin was up-regulated both in vitro and in vivo. Animal studies further revealed that Xanthatin killed the tumor cells around the blood vessels which contributes to reduce microvascular density extremely. All these results indicate that Xanthatin inhibited murine melanoma B16-F10 cell proliferation possibly associated with activation of Wnt/β-catenin pathway and its activity against melanoma tumor might also be relevant to inhibition of angiogenesis. |
| doi_str_mv | 10.1016/j.phymed.2013.03.006 |
| format | Article |
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We herein reported the anti-tumor effects of Xanthatin both in vitro and in vivo. MTS assay results showed that Xanthatin had a remarkable anti-proliferative effect on B16-F10 cells. Moreover, the expression of β-catenin was up-regulated both in vitro and in vivo. Animal studies further revealed that Xanthatin killed the tumor cells around the blood vessels which contributes to reduce microvascular density extremely. All these results indicate that Xanthatin inhibited murine melanoma B16-F10 cell proliferation possibly associated with activation of Wnt/β-catenin pathway and its activity against melanoma tumor might also be relevant to inhibition of angiogenesis.</description><identifier>ISSN: 0944-7113</identifier><identifier>EISSN: 1618-095X</identifier><identifier>DOI: 10.1016/j.phymed.2013.03.006</identifier><identifier>PMID: 23664560</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Animals ; Antineoplastic Agents, Phytogenic - isolation & purification ; Antineoplastic Agents, Phytogenic - pharmacology ; Antineoplastic Agents, Phytogenic - therapeutic use ; Apoptosis ; Cancer ; Care and treatment ; Cell Line, Tumor ; Cell Proliferation - drug effects ; Chemical properties ; Furans - isolation & purification ; Furans - pharmacology ; Furans - therapeutic use ; Male ; Melanoma ; Melanoma, Experimental - pathology ; Melanoma, Experimental - prevention & control ; Mice ; Mice, Inbred C57BL ; Random Allocation ; Tumors ; Wnt/β-catenin signaling ; Xanthatin ; Xanthium - chemistry ; Xenograft Model Antitumor Assays</subject><ispartof>Phytomedicine (Stuttgart), 2013-07, Vol.20 (10), p.865-873</ispartof><rights>2013 Elsevier GmbH</rights><rights>Copyright © 2013 Elsevier GmbH. All rights reserved.</rights><rights>COPYRIGHT 2013 Urban & Fischer Verlag</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c557t-57609d4597ab6717000241cf8b7aa94b67fa190f4d732f12fb1cbe8236a6c8f3</citedby><cites>FETCH-LOGICAL-c557t-57609d4597ab6717000241cf8b7aa94b67fa190f4d732f12fb1cbe8236a6c8f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0944711313000925$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23664560$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Wei D.</creatorcontrib><creatorcontrib>Wu, Yu</creatorcontrib><creatorcontrib>Zhang, Lei</creatorcontrib><creatorcontrib>Yan, Ling G.</creatorcontrib><creatorcontrib>Yin, Fang Z.</creatorcontrib><creatorcontrib>Ruan, Jun S.</creatorcontrib><creatorcontrib>Chen, Zhi P.</creatorcontrib><creatorcontrib>Yang, Guang M.</creatorcontrib><creatorcontrib>Yan, Cui P.</creatorcontrib><creatorcontrib>Zhao, Ding</creatorcontrib><creatorcontrib>Lu, Yin</creatorcontrib><creatorcontrib>Cai, Bao C.</creatorcontrib><title>Characterization of xanthatin: Anticancer properties and mechanisms of inhibited murine melanoma in vitro and in vivo</title><title>Phytomedicine (Stuttgart)</title><addtitle>Phytomedicine</addtitle><description>Anti-cancer investigations on Xanthatin mainly focus on in vitro experiments. We herein reported the anti-tumor effects of Xanthatin both in vitro and in vivo. MTS assay results showed that Xanthatin had a remarkable anti-proliferative effect on B16-F10 cells. Moreover, the expression of β-catenin was up-regulated both in vitro and in vivo. Animal studies further revealed that Xanthatin killed the tumor cells around the blood vessels which contributes to reduce microvascular density extremely. All these results indicate that Xanthatin inhibited murine melanoma B16-F10 cell proliferation possibly associated with activation of Wnt/β-catenin pathway and its activity against melanoma tumor might also be relevant to inhibition of angiogenesis.</description><subject>Animals</subject><subject>Antineoplastic Agents, Phytogenic - isolation & purification</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>Antineoplastic Agents, Phytogenic - therapeutic use</subject><subject>Apoptosis</subject><subject>Cancer</subject><subject>Care and treatment</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - drug effects</subject><subject>Chemical properties</subject><subject>Furans - isolation & purification</subject><subject>Furans - pharmacology</subject><subject>Furans - therapeutic use</subject><subject>Male</subject><subject>Melanoma</subject><subject>Melanoma, Experimental - pathology</subject><subject>Melanoma, Experimental - prevention & control</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Random Allocation</subject><subject>Tumors</subject><subject>Wnt/β-catenin signaling</subject><subject>Xanthatin</subject><subject>Xanthium - chemistry</subject><subject>Xenograft Model Antitumor Assays</subject><issn>0944-7113</issn><issn>1618-095X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kk2L2zAQhk1p6Wa3_QelNfSyF6eSLUtWD4UQ-gULPXQLvQlZHiUKsZRKSuj213e83j0UQtGA0Mzzihm9KopXlCwpofzdbnnY3o0wLGtCmyXBIPxJsaCcdhWR7c-nxYJIxipBaXNRXKa0I4QyKcjz4qJuOGctJ4viuN7qqE2G6P7o7IIvgy1_a5-3ePLvy5XPzmhvIJaHGA4Qs4NUaj-UI5it9i6NaZI4v3W9y4D5Y3QesLzXPowaK-XJ5RjuRfeHU3hRPLN6n-Dlw35V3H76eLv-Ut18-_x1vbqpTNuKXLWCEzmwVgrdc0EFIaRm1NiuF1pLhjmrqSSWDaKpLa1tT00PHU6nuelsc1Vcz9di67-OkLIaXTKwx84gHJOijexYw2rZIPp2Rjd6D8p5GzI-y4SrVcOobDrBaqSqM9QGPES9Dx6sw_Q__PIMj2uA0ZmzAjYLTAwpRbDqEN2o452iRE22q52abVeT7YpgEI6y1w-DHvup9ih69BmBNzNgdVB6E11SP77jDRz_hOCCSSQ-zASgHycHUSXjAI0fXAST1RDc_3v4C9KGyPc</recordid><startdate>20130715</startdate><enddate>20130715</enddate><creator>Li, Wei D.</creator><creator>Wu, Yu</creator><creator>Zhang, Lei</creator><creator>Yan, Ling G.</creator><creator>Yin, Fang Z.</creator><creator>Ruan, Jun S.</creator><creator>Chen, Zhi P.</creator><creator>Yang, Guang M.</creator><creator>Yan, Cui P.</creator><creator>Zhao, Ding</creator><creator>Lu, Yin</creator><creator>Cai, Bao C.</creator><general>Elsevier GmbH</general><general>Urban & Fischer Verlag</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130715</creationdate><title>Characterization of xanthatin: Anticancer properties and mechanisms of inhibited murine melanoma in vitro and in vivo</title><author>Li, Wei D. ; Wu, Yu ; Zhang, Lei ; Yan, Ling G. ; Yin, Fang Z. ; Ruan, Jun S. ; Chen, Zhi P. ; Yang, Guang M. ; Yan, Cui P. ; Zhao, Ding ; Lu, Yin ; Cai, Bao C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c557t-57609d4597ab6717000241cf8b7aa94b67fa190f4d732f12fb1cbe8236a6c8f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Antineoplastic Agents, Phytogenic - isolation & purification</topic><topic>Antineoplastic Agents, Phytogenic - pharmacology</topic><topic>Antineoplastic Agents, Phytogenic - therapeutic use</topic><topic>Apoptosis</topic><topic>Cancer</topic><topic>Care and treatment</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation - drug effects</topic><topic>Chemical properties</topic><topic>Furans - isolation & purification</topic><topic>Furans - pharmacology</topic><topic>Furans - therapeutic use</topic><topic>Male</topic><topic>Melanoma</topic><topic>Melanoma, Experimental - pathology</topic><topic>Melanoma, Experimental - prevention & control</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Random Allocation</topic><topic>Tumors</topic><topic>Wnt/β-catenin signaling</topic><topic>Xanthatin</topic><topic>Xanthium - chemistry</topic><topic>Xenograft Model Antitumor Assays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Wei D.</creatorcontrib><creatorcontrib>Wu, Yu</creatorcontrib><creatorcontrib>Zhang, Lei</creatorcontrib><creatorcontrib>Yan, Ling G.</creatorcontrib><creatorcontrib>Yin, Fang Z.</creatorcontrib><creatorcontrib>Ruan, Jun S.</creatorcontrib><creatorcontrib>Chen, Zhi P.</creatorcontrib><creatorcontrib>Yang, Guang M.</creatorcontrib><creatorcontrib>Yan, Cui P.</creatorcontrib><creatorcontrib>Zhao, Ding</creatorcontrib><creatorcontrib>Lu, Yin</creatorcontrib><creatorcontrib>Cai, Bao C.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Phytomedicine (Stuttgart)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Wei D.</au><au>Wu, Yu</au><au>Zhang, Lei</au><au>Yan, Ling G.</au><au>Yin, Fang Z.</au><au>Ruan, Jun S.</au><au>Chen, Zhi P.</au><au>Yang, Guang M.</au><au>Yan, Cui P.</au><au>Zhao, Ding</au><au>Lu, Yin</au><au>Cai, Bao C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization of xanthatin: Anticancer properties and mechanisms of inhibited murine melanoma in vitro and in vivo</atitle><jtitle>Phytomedicine (Stuttgart)</jtitle><addtitle>Phytomedicine</addtitle><date>2013-07-15</date><risdate>2013</risdate><volume>20</volume><issue>10</issue><spage>865</spage><epage>873</epage><pages>865-873</pages><issn>0944-7113</issn><eissn>1618-095X</eissn><abstract>Anti-cancer investigations on Xanthatin mainly focus on in vitro experiments. We herein reported the anti-tumor effects of Xanthatin both in vitro and in vivo. MTS assay results showed that Xanthatin had a remarkable anti-proliferative effect on B16-F10 cells. Moreover, the expression of β-catenin was up-regulated both in vitro and in vivo. Animal studies further revealed that Xanthatin killed the tumor cells around the blood vessels which contributes to reduce microvascular density extremely. All these results indicate that Xanthatin inhibited murine melanoma B16-F10 cell proliferation possibly associated with activation of Wnt/β-catenin pathway and its activity against melanoma tumor might also be relevant to inhibition of angiogenesis.</abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>23664560</pmid><doi>10.1016/j.phymed.2013.03.006</doi><tpages>9</tpages></addata></record> |
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| subjects | Animals Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Antineoplastic Agents, Phytogenic - therapeutic use Apoptosis Cancer Care and treatment Cell Line, Tumor Cell Proliferation - drug effects Chemical properties Furans - isolation & purification Furans - pharmacology Furans - therapeutic use Male Melanoma Melanoma, Experimental - pathology Melanoma, Experimental - prevention & control Mice Mice, Inbred C57BL Random Allocation Tumors Wnt/β-catenin signaling Xanthatin Xanthium - chemistry Xenograft Model Antitumor Assays |
| title | Characterization of xanthatin: Anticancer properties and mechanisms of inhibited murine melanoma in vitro and in vivo |
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