Evaluation of canine T-cell dependent antibody response to the primary and secondary immunization with keyhole limpet hemocyanin

T-cell dependent antibody response (TDAR) incorporating both primary and secondary responses to keyhole limpet hemocyanin (KLH) in canine models have not yet been fully understood. To develop a practical dog TDAR model, we characterized primary and secondary antibody responses by intravenous or intr...

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Veröffentlicht in:	Journal of toxicological sciences 2013/08/01, Vol.38(4), pp.571-579
Hauptverfasser:	Kawai, Ryota, Aida, Tetsuo, Hattori, Hiroyuki, Furukawa, Tadashi, Mori, Kazuhiko, Takasaki, Wataru, Takahashi, Nobuyuki, Kawada, Teruo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic Animals Antibody Formation - immunology Cyclophosphamide Cyclophosphamide - pharmacology Dogs Female Hemocyanins - administration & dosage Hemocyanins - immunology Humans Immunity, Humoral - immunology Immunization, Secondary Immunoglobulin G - blood Immunosuppressive Agents - pharmacology Injections, Intramuscular Injections, Intravenous KLH Male Primary and secondary response T-Lymphocytes - immunology TDAR
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