In vitro inhibition of natural killer cell activity by doxycycline
The effect of four tetracyclines, tetracycline, rolitetracycline, oxytetracycline and doxycycline, on human natural killer (NK) cell-mediated cytotoxicity was examined in vitro. Doxycycline was the only tetracycline which inhibited the NK cell activity. At concentrationsof 10 μg/ml the drug caused a...
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| Veröffentlicht in: | International journal of immunopharmacology 1984, Vol.6 (1), p.51-54 |
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| container_end_page | 54 |
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| container_issue | 1 |
| container_start_page | 51 |
| container_title | International journal of immunopharmacology |
| container_volume | 6 |
| creator | Goh, D.H.B. Ferrante, A. |
| description | The effect of four tetracyclines, tetracycline, rolitetracycline, oxytetracycline and doxycycline, on human natural killer (NK) cell-mediated cytotoxicity was examined
in vitro. Doxycycline was the only tetracycline which inhibited the NK cell activity. At concentrationsof 10 μg/ml the drug caused approximately 50% inhibition of NK cell mediated cytotoxicity against K562 target. The inhibition was not a result of a toxic effect of the drug on NK cells. These results support the previous findings that doxycycline shows immunosuppressive properties. |
| doi_str_mv | 10.1016/0192-0561(84)90034-1 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0192-0561 |
| ispartof | International journal of immunopharmacology, 1984, Vol.6 (1), p.51-54 |
| issn | 0192-0561 1879-3495 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_13957952 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Cell Line Cells, Cultured Cytotoxicity Tests, Immunologic Cytotoxicity, Immunologic - drug effects Doxycycline - pharmacology Humans Killer Cells, Natural - immunology Medical sciences Monocytes - immunology Pharmacology. Drug treatments Tetracyclines - pharmacology |
| title | In vitro inhibition of natural killer cell activity by doxycycline |
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