Species and strain comparison of the metabolism of gentian violet by liver microsomes
Comparative metabolism of hexamethylpararosaniline chloride, a poultry feed additive known as gentian violet, was examined in vitro in the presence of uninduced liver microsomes prepared from both sexes of four mouse strains, three rat strains, hamster, guinea pig, and chicken. Metabolites, isolated...
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| Veröffentlicht in: | Journal of agricultural and food chemistry 1984-05, Vol.32 (3), p.596-600 |
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| container_title | Journal of agricultural and food chemistry |
| container_volume | 32 |
| creator | McDonald, Jerome J Breeden, Cloyd R North, Betty M Roth, Robert W |
| description | Comparative metabolism of hexamethylpararosaniline chloride, a poultry feed additive known as gentian violet, was examined in vitro in the presence of uninduced liver microsomes prepared from both sexes of four mouse strains, three rat strains, hamster, guinea pig, and chicken. Metabolites, isolated by solvent extraction and HPLC, were identified by comparison of reverse-phase HPLC retention times and electron impact mass spectral fragmentation patterns with those of standards prepared by unambiguous synthetic routes. The major metabolites were pentamethylpararosaniline and the isomeric N,N,N',N'- and N,-N,N',N"-tetramethylpararosanilines. The pattern of demethylated metabolites was found to be comparable among the species with little difference between the sexes. |
| doi_str_mv | 10.1021/jf00123a044 |
| format | Article |
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Metabolites, isolated by solvent extraction and HPLC, were identified by comparison of reverse-phase HPLC retention times and electron impact mass spectral fragmentation patterns with those of standards prepared by unambiguous synthetic routes. The major metabolites were pentamethylpararosaniline and the isomeric N,N,N',N'- and N,-N,N',N"-tetramethylpararosanilines. 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Agric. Food Chem</addtitle><description>Comparative metabolism of hexamethylpararosaniline chloride, a poultry feed additive known as gentian violet, was examined in vitro in the presence of uninduced liver microsomes prepared from both sexes of four mouse strains, three rat strains, hamster, guinea pig, and chicken. Metabolites, isolated by solvent extraction and HPLC, were identified by comparison of reverse-phase HPLC retention times and electron impact mass spectral fragmentation patterns with those of standards prepared by unambiguous synthetic routes. The major metabolites were pentamethylpararosaniline and the isomeric N,N,N',N'- and N,-N,N',N"-tetramethylpararosanilines. The pattern of demethylated metabolites was found to be comparable among the species with little difference between the sexes.</description><subject>Biological and medical sciences</subject><subject>Medical sciences</subject><subject>Pesticides, fertilizers and other agrochemicals toxicology</subject><subject>Toxicology</subject><issn>0021-8561</issn><issn>1520-5118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><recordid>eNptkE9LAzEQxYMoWKsnv0AOogdZnWya_XPUolWoKNqit5BmZzV1d1Mz26Lf3i0V8eBpYN7vPR6PsUMBZwJicT4vAUQsDQwGW6wnVAyREiLbZj3o5ChTidhle0RzAMhUCj02fVqgdUjcNAWnNhjXcOvrhQmOfMN9yds35DW2ZuYrR_X684pN60zDV85X2PLZF6_cCgOvnQ2efI20z3ZKUxEe_Nw-m15fTYY30fh-dDu8GEdGJqKNZnZQdE1MKiBXGSoLhRQKRR7PktImSa4wyQUKCXGaIeAgL8oC0ySGDoQylX12vMldBP-xRGp17chiVZkG_ZK0kLmSXUQHnm7AdUMKWOpFcLUJX1qAXk-n_0zX0Uc_sYasqcpgGuvo15IDSCnXWLTBHLX4-Sub8K6TVKZKTx6e9CWMIH5-udOPHX-y4Y0lPffL0HTb_FvgG3k3iPs</recordid><startdate>19840501</startdate><enddate>19840501</enddate><creator>McDonald, Jerome J</creator><creator>Breeden, Cloyd R</creator><creator>North, Betty M</creator><creator>Roth, Robert W</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19840501</creationdate><title>Species and strain comparison of the metabolism of gentian violet by liver microsomes</title><author>McDonald, Jerome J ; Breeden, Cloyd R ; North, Betty M ; Roth, Robert W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a361t-bc4d000a710958e5c0d315e192b6fc6695e691e130278e0e49dfde76200d30f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Biological and medical sciences</topic><topic>Medical sciences</topic><topic>Pesticides, fertilizers and other agrochemicals toxicology</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McDonald, Jerome J</creatorcontrib><creatorcontrib>Breeden, Cloyd R</creatorcontrib><creatorcontrib>North, Betty M</creatorcontrib><creatorcontrib>Roth, Robert W</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Journal of agricultural and food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McDonald, Jerome J</au><au>Breeden, Cloyd R</au><au>North, Betty M</au><au>Roth, Robert W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Species and strain comparison of the metabolism of gentian violet by liver microsomes</atitle><jtitle>Journal of agricultural and food chemistry</jtitle><addtitle>J. Agric. Food Chem</addtitle><date>1984-05-01</date><risdate>1984</risdate><volume>32</volume><issue>3</issue><spage>596</spage><epage>600</epage><pages>596-600</pages><issn>0021-8561</issn><eissn>1520-5118</eissn><coden>JAFCAU</coden><abstract>Comparative metabolism of hexamethylpararosaniline chloride, a poultry feed additive known as gentian violet, was examined in vitro in the presence of uninduced liver microsomes prepared from both sexes of four mouse strains, three rat strains, hamster, guinea pig, and chicken. Metabolites, isolated by solvent extraction and HPLC, were identified by comparison of reverse-phase HPLC retention times and electron impact mass spectral fragmentation patterns with those of standards prepared by unambiguous synthetic routes. The major metabolites were pentamethylpararosaniline and the isomeric N,N,N',N'- and N,-N,N',N"-tetramethylpararosanilines. 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| ispartof | Journal of agricultural and food chemistry, 1984-05, Vol.32 (3), p.596-600 |
| issn | 0021-8561 1520-5118 |
| language | eng |
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| source | American Chemical Society Journals |
| subjects | Biological and medical sciences Medical sciences Pesticides, fertilizers and other agrochemicals toxicology Toxicology |
| title | Species and strain comparison of the metabolism of gentian violet by liver microsomes |
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