Double deficiency in IL-17 and IFN-γ signalling significantly suppresses the development of diabetes in the NOD mouse

Aims/hypothesis T helper type (Th) 17 cells have been shown to play important roles in mouse models of several autoimmune diseases that have been classified as Th1 diseases. In the NOD mouse, the relevance of Th1 and Th17 is controversial, because single-cytokine-deficient NOD mice develop diabetes...

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Veröffentlicht in:	Diabetologia 2013-08, Vol.56 (8), p.1773-1780
Hauptverfasser:	Kuriya, G., Uchida, T., Akazawa, S., Kobayashi, M., Nakamura, K., Satoh, T., Horie, I., Kawasaki, E., Yamasaki, H., Yu, L., Iwakura, Y., Sasaki, H., Nagayama, Y., Kawakami, A., Abiru, N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animals Autoantibodies - genetics Autoantibodies - immunology Biological and medical sciences Diabetes Mellitus, Type 1 - genetics Diabetes Mellitus, Type 1 - immunology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Flow Cytometry Hematologic and hematopoietic diseases Human Physiology Interferon-gamma - deficiency Interferon-gamma - genetics Interleukin-17 - deficiency Interleukin-17 - genetics Internal Medicine Male Medical sciences Medicine Medicine & Public Health Metabolic Diseases Mice Mice, Inbred NOD Mice, Mutant Strains Mice, SCID Other diseases. Hematologic involvement in other diseases
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