Potentiation of acetazolamide induced ectrodactyly in SWV and C57BL/6J mice by Cadmium Sulfate
CdSO4 and acetazolamide each induce postaxial ectrodactyly in rodents when administered at a critical time in forelimb development. C57BL/6J mice are extremely sensitive to the teratogenic action of both agents, whereas SWV mice are relatively resistant. Additionally, both of these agents can inhibi...
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| Veröffentlicht in: | Teratology (Philadelphia) 1984-06, Vol.29 (3), p.427-435 |
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| container_end_page | 435 |
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| container_issue | 3 |
| container_start_page | 427 |
| container_title | Teratology (Philadelphia) |
| container_volume | 29 |
| creator | Kuczuk, Maureen H. Scott Jr, William J. |
| description | CdSO4 and acetazolamide each induce postaxial ectrodactyly in rodents when administered at a critical time in forelimb development. C57BL/6J mice are extremely sensitive to the teratogenic action of both agents, whereas SWV mice are relatively resistant. Additionally, both of these agents can inhibit carbonic anhydrase. In the present study administration of CdSO4 and acetazolamide in combination to either strain of mice potentiates the incidence of forelimb ectrodactyly. These results, in combination with the aforementioned similarities of teratogenesis, suggest a common mechanism of teratogenesis. |
| doi_str_mv | 10.1002/tera.1420290314 |
| format | Article |
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C57BL/6J mice are extremely sensitive to the teratogenic action of both agents, whereas SWV mice are relatively resistant. Additionally, both of these agents can inhibit carbonic anhydrase. In the present study administration of CdSO4 and acetazolamide in combination to either strain of mice potentiates the incidence of forelimb ectrodactyly. These results, in combination with the aforementioned similarities of teratogenesis, suggest a common mechanism of teratogenesis.</description><identifier>ISSN: 0040-3709</identifier><identifier>EISSN: 1096-9926</identifier><identifier>DOI: 10.1002/tera.1420290314</identifier><identifier>PMID: 6463905</identifier><identifier>CODEN: TJADAB</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Abnormalities, Drug-Induced ; Acetazolamide - toxicity ; Animals ; Biological and medical sciences ; Cadmium - toxicity ; Cadmium Compounds ; Drug Synergism ; Embryology: invertebrates and vertebrates. Teratology ; Female ; Fetus - drug effects ; Foot Deformities, Congenital ; Forelimb - abnormalities ; Fundamental and applied biological sciences. Psychology ; Hindlimb - abnormalities ; Mice ; Mice, Inbred C57BL ; Mice, Inbred Strains ; Pregnancy ; Reproduction - drug effects ; Sulfates ; Teratology. 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C57BL/6J mice are extremely sensitive to the teratogenic action of both agents, whereas SWV mice are relatively resistant. Additionally, both of these agents can inhibit carbonic anhydrase. In the present study administration of CdSO4 and acetazolamide in combination to either strain of mice potentiates the incidence of forelimb ectrodactyly. These results, in combination with the aforementioned similarities of teratogenesis, suggest a common mechanism of teratogenesis.</description><subject>Abnormalities, Drug-Induced</subject><subject>Acetazolamide - toxicity</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cadmium - toxicity</subject><subject>Cadmium Compounds</subject><subject>Drug Synergism</subject><subject>Embryology: invertebrates and vertebrates. Teratology</subject><subject>Female</subject><subject>Fetus - drug effects</subject><subject>Foot Deformities, Congenital</subject><subject>Forelimb - abnormalities</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hindlimb - abnormalities</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Inbred Strains</subject><subject>Pregnancy</subject><subject>Reproduction - drug effects</subject><subject>Sulfates</subject><subject>Teratology. Teratogens</subject><issn>0040-3709</issn><issn>1096-9926</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtv1DAUhS0EKkPbNSskLxC7dPxKHItViUoBjaAv6A7rxg_JkEexHUH49WQ0o0GsWF3pnu-ce3UQek7JGSWErbOLcEYFI0wRTsUjtKJEVYVSrHqMVoQIUnBJ1FP0LKVvhFBCKT9CR5WouCLlCn29GrMbcoAcxgGPHoNxGX6PHfTBOhwGOxlnsTM5jhZMnrt5WeLb-y8YBoubUr7ZrKsPuA_G4XbGDdg-TD2-nToP2Z2gJx665E738xh9fntx17wrNp8u3zfnm8IIwUQhSunBU68Y98BNXVkpDNS-VsoqQVnJGaWetlJJJjgRQjHhrW29B9JS5_gxerXLfYjjj8mlrPuQjOs6GNw4JU354pB1vYDrHWjimFJ0Xj_E0EOcNSV626jeNqr_Nro4Xuyjp7Z39sDvK1z0l3sdkoHORxhMSAesrpWs5RZ7vcN-hs7N_7uq7y5uzv95oti5Q8ru18EN8buuJJelvv94qa8rsbmWTaUV_wPMKJ3K</recordid><startdate>198406</startdate><enddate>198406</enddate><creator>Kuczuk, Maureen H.</creator><creator>Scott Jr, William J.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7U2</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>198406</creationdate><title>Potentiation of acetazolamide induced ectrodactyly in SWV and C57BL/6J mice by Cadmium Sulfate</title><author>Kuczuk, Maureen H. ; Scott Jr, William J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4424-457faf1f923fa3c86d74ca8f899d941253211f1b797243044924fddbffa0b1ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Abnormalities, Drug-Induced</topic><topic>Acetazolamide - toxicity</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cadmium - toxicity</topic><topic>Cadmium Compounds</topic><topic>Drug Synergism</topic><topic>Embryology: invertebrates and vertebrates. Teratology</topic><topic>Female</topic><topic>Fetus - drug effects</topic><topic>Foot Deformities, Congenital</topic><topic>Forelimb - abnormalities</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hindlimb - abnormalities</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Inbred Strains</topic><topic>Pregnancy</topic><topic>Reproduction - drug effects</topic><topic>Sulfates</topic><topic>Teratology. Teratogens</topic><toplevel>online_resources</toplevel><creatorcontrib>Kuczuk, Maureen H.</creatorcontrib><creatorcontrib>Scott Jr, William J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Teratology (Philadelphia)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kuczuk, Maureen H.</au><au>Scott Jr, William J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Potentiation of acetazolamide induced ectrodactyly in SWV and C57BL/6J mice by Cadmium Sulfate</atitle><jtitle>Teratology (Philadelphia)</jtitle><addtitle>Teratology</addtitle><date>1984-06</date><risdate>1984</risdate><volume>29</volume><issue>3</issue><spage>427</spage><epage>435</epage><pages>427-435</pages><issn>0040-3709</issn><eissn>1096-9926</eissn><coden>TJADAB</coden><abstract>CdSO4 and acetazolamide each induce postaxial ectrodactyly in rodents when administered at a critical time in forelimb development. C57BL/6J mice are extremely sensitive to the teratogenic action of both agents, whereas SWV mice are relatively resistant. Additionally, both of these agents can inhibit carbonic anhydrase. In the present study administration of CdSO4 and acetazolamide in combination to either strain of mice potentiates the incidence of forelimb ectrodactyly. These results, in combination with the aforementioned similarities of teratogenesis, suggest a common mechanism of teratogenesis.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>6463905</pmid><doi>10.1002/tera.1420290314</doi><tpages>9</tpages></addata></record> |
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| ispartof | Teratology (Philadelphia), 1984-06, Vol.29 (3), p.427-435 |
| issn | 0040-3709 1096-9926 |
| language | eng |
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| subjects | Abnormalities, Drug-Induced Acetazolamide - toxicity Animals Biological and medical sciences Cadmium - toxicity Cadmium Compounds Drug Synergism Embryology: invertebrates and vertebrates. Teratology Female Fetus - drug effects Foot Deformities, Congenital Forelimb - abnormalities Fundamental and applied biological sciences. Psychology Hindlimb - abnormalities Mice Mice, Inbred C57BL Mice, Inbred Strains Pregnancy Reproduction - drug effects Sulfates Teratology. Teratogens |
| title | Potentiation of acetazolamide induced ectrodactyly in SWV and C57BL/6J mice by Cadmium Sulfate |
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