Monitoring of organ formation in rat embryos after in vitro exposure to azathioprine, mercaptopurine, methotrexate or cyclosporin A

Rat embryos in the organ formation phase (days 9.5–11.5 post coitum) were cultivated in pure rat serum in the presence of an Aroclor 1254 pretreated liver microsomal preparation (S9-mix). Various concentrations of the immunosuppressive drugs azathioprine (AZ), 6-mercaptopurine (MP), methotrexate (MT...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Toxicology (Amsterdam) 1984-05, Vol.31 (1), p.9-21
1. Verfasser:	Schmid, B.P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities, Drug-Induced Animals Azathioprine - toxicity Biological and medical sciences Brain - abnormalities Cyclosporins - toxicity Dose-Response Relationship, Drug Embryology: invertebrates and vertebrates. Teratology Female Fundamental and applied biological sciences. Psychology Male Mercaptopurine - toxicity Methotrexate - toxicity Organ Culture Techniques Pregnancy Rats Rats, Inbred Strains Teratology. Teratogens
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!