Mutagenicity produced by aqueous chlorination of organic compounds [unbleached kraft pulp]
Of 93 substances studied, only 1,3-dichloroacetone, 1,1,3,3,-tetrachloroacetone, 3,6-dichloro-2-hydroxybenzaldehyde , dibromomethane and mucochloric acid were mutagenic, but not toxic, to Salmonella TA 100 (Ames) . Forty-three compounds systematically chlorinated were mutagenic, except p-benzoquinon...
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| Veröffentlicht in: | Bulletin of environmental contamination and toxicology 1980-12, Vol.24 (4), p.590-596 |
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| container_title | Bulletin of environmental contamination and toxicology |
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| creator | Rapson, W H Nazar, M A Butsky, V V |
| description | Of 93 substances studied, only 1,3-dichloroacetone, 1,1,3,3,-tetrachloroacetone, 3,6-dichloro-2-hydroxybenzaldehyde , dibromomethane and mucochloric acid were mutagenic, but not toxic, to Salmonella TA 100 (Ames) . Forty-three compounds systematically chlorinated were mutagenic, except p-benzoquinone, tetrachlorocatechol, tetrachloroguaiacol, tetrachloro-o-quinone, abietic acid, acetone and caffeine, all of which were toxic, and glyoxal, benzoic acid and maleic acid which produced neither mutagenicity nor toxicity. Chlorination of fumaric acid and trans-butenedioic acid produced a positive Ames test while chlorination of maleic acid did not. Lignin was the main source of mutagenicity by chlorinated woodpulp. |
| doi_str_mv | 10.1007/bf01608160 |
| format | Article |
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Forty-three compounds systematically chlorinated were mutagenic, except p-benzoquinone, tetrachlorocatechol, tetrachloroguaiacol, tetrachloro-o-quinone, abietic acid, acetone and caffeine, all of which were toxic, and glyoxal, benzoic acid and maleic acid which produced neither mutagenicity nor toxicity. Chlorination of fumaric acid and trans-butenedioic acid produced a positive Ames test while chlorination of maleic acid did not. 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Forty-three compounds systematically chlorinated were mutagenic, except p-benzoquinone, tetrachlorocatechol, tetrachloroguaiacol, tetrachloro-o-quinone, abietic acid, acetone and caffeine, all of which were toxic, and glyoxal, benzoic acid and maleic acid which produced neither mutagenicity nor toxicity. Chlorination of fumaric acid and trans-butenedioic acid produced a positive Ames test while chlorination of maleic acid did not. Lignin was the main source of mutagenicity by chlorinated woodpulp.</description><subject>Chemical Phenomena</subject><subject>Chemistry</subject><subject>Chlorine</subject><subject>Fresh Water</subject><subject>Hydrocarbons, Chlorinated - toxicity</subject><subject>Hydrogen-Ion Concentration</subject><subject>Mutagens</subject><subject>Salmonella typhimurium - genetics</subject><issn>0007-4861</issn><issn>1432-0800</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kL1PwzAQxS0EgvKxsIM8MSAFznbqjxEqCkhFDMACQpHj2CWQxMFOhv73GLUwnE6697vTu4fQMYELAiAuSweEg0y1hSYkZzQDCbCNJpDULJec7KH9GD8ByFRSuot2uVIEGEzQ68M46KXtalMPK9wHX43GVrhcYf09Wj9GbD4aH-pOD7XvsHfYh6VOODa-7f3YVRG_jV3ZWG0-0uJX0G7A_dj074dox-km2qNNP0Av85vn2V22eLy9n10tMpMDHTI6dcZARRVjQjPKlSsNEUZRVmlhJQeqK14Kx0HYNFZM5FyUUjjKcqmYZAfobH03uU-e41C0dTS2aXT3-0BBmCJpBxJ4vgZN8DEG64o-1K0Oq4JA8RtkcT3_CzLBJ5urY9na6h_dJJf007XutC_0MtSxeHkiShLgfKqAsB8sDHbc</recordid><startdate>198012</startdate><enddate>198012</enddate><creator>Rapson, W H</creator><creator>Nazar, M A</creator><creator>Butsky, V V</creator><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QH</scope></search><sort><creationdate>198012</creationdate><title>Mutagenicity produced by aqueous chlorination of organic compounds [unbleached kraft pulp]</title><author>Rapson, W H ; Nazar, M A ; Butsky, V V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-25fcc0d29337a3269fbc17c923da7e8602ad6b7f607e7c9937467b87f23489383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Chemical Phenomena</topic><topic>Chemistry</topic><topic>Chlorine</topic><topic>Fresh Water</topic><topic>Hydrocarbons, Chlorinated - toxicity</topic><topic>Hydrogen-Ion Concentration</topic><topic>Mutagens</topic><topic>Salmonella typhimurium - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rapson, W H</creatorcontrib><creatorcontrib>Nazar, M A</creatorcontrib><creatorcontrib>Butsky, V V</creatorcontrib><creatorcontrib>International Organization for Standardization, Geneva (Switzerland)</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aqualine</collection><jtitle>Bulletin of environmental contamination and toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rapson, W H</au><au>Nazar, M A</au><au>Butsky, V V</au><aucorp>International Organization for Standardization, Geneva (Switzerland)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mutagenicity produced by aqueous chlorination of organic compounds [unbleached kraft pulp]</atitle><jtitle>Bulletin of environmental contamination and toxicology</jtitle><addtitle>Bull Environ Contam Toxicol</addtitle><date>1980-12</date><risdate>1980</risdate><volume>24</volume><issue>4</issue><spage>590</spage><epage>596</epage><pages>590-596</pages><issn>0007-4861</issn><eissn>1432-0800</eissn><abstract>Of 93 substances studied, only 1,3-dichloroacetone, 1,1,3,3,-tetrachloroacetone, 3,6-dichloro-2-hydroxybenzaldehyde , dibromomethane and mucochloric acid were mutagenic, but not toxic, to Salmonella TA 100 (Ames) . 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| fulltext | fulltext |
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| ispartof | Bulletin of environmental contamination and toxicology, 1980-12, Vol.24 (4), p.590-596 |
| issn | 0007-4861 1432-0800 |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Chemical Phenomena Chemistry Chlorine Fresh Water Hydrocarbons, Chlorinated - toxicity Hydrogen-Ion Concentration Mutagens Salmonella typhimurium - genetics |
| title | Mutagenicity produced by aqueous chlorination of organic compounds [unbleached kraft pulp] |
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