DNA polyintercalation: comparison of DNA binding properties of an acridine dimer and trimer
The DNA binding characteristics of a mono-, di- and trimeric derivative of 9-aminoacridine were studied. The length of the linking carboxyamidoalkyl chains was selected to allow bis- or tris-intercalation according to the excluded-site model. Measurements of DNA unwinding angle using closed circular...
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| Veröffentlicht in: | FEBS letters 1984-04, Vol.169 (2), p.123-126 |
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| container_title | FEBS letters |
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| creator | Gaugain, Bernard Markovits, Judith Le Pecq, Jean-Bernard Roques, Bernard P. |
| description | The DNA binding characteristics of a mono-, di- and trimeric derivative of 9-aminoacridine were studied. The length of the linking carboxyamidoalkyl chains was selected to allow bis- or tris-intercalation according to the excluded-site model. Measurements of DNA unwinding angle using closed circular DNA showed that the trimeric derivative behaves as a tris-intercalating agent. Nevertheless the increase of DNA binding affinity on going from dimer to trimer was found to be relatively small. This is probably related to the large structural constraint for DNA binding of the trimeric derivative. The nature of the linking chain for the design of high-affinity DNA poly-intercalating agents appears therefore critical. |
| doi_str_mv | 10.1016/0014-5793(84)80302-6 |
| format | Article |
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Associations ; Intermolecular phenomena ; Macromolecular Substances ; Molecular biophysics ; Poly dA-dT - metabolism ; Tris-intercalation ; Viscosimetry ; Viscosity</subject><ispartof>FEBS letters, 1984-04, Vol.169 (2), p.123-126</ispartof><rights>1984</rights><rights>FEBS Letters 169 (1984) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5926-18e9744c7bfcc358420eee509095a77db5f6e405631df2079d2abd2f930e7e733</citedby><cites>FETCH-LOGICAL-c5926-18e9744c7bfcc358420eee509095a77db5f6e405631df2079d2abd2f930e7e733</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0014-5793(84)80302-6$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8944234$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6714420$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gaugain, Bernard</creatorcontrib><creatorcontrib>Markovits, Judith</creatorcontrib><creatorcontrib>Le Pecq, Jean-Bernard</creatorcontrib><creatorcontrib>Roques, Bernard P.</creatorcontrib><title>DNA polyintercalation: comparison of DNA binding properties of an acridine dimer and trimer</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>The DNA binding characteristics of a mono-, di- and trimeric derivative of 9-aminoacridine were studied. The length of the linking carboxyamidoalkyl chains was selected to allow bis- or tris-intercalation according to the excluded-site model. Measurements of DNA unwinding angle using closed circular DNA showed that the trimeric derivative behaves as a tris-intercalating agent. Nevertheless the increase of DNA binding affinity on going from dimer to trimer was found to be relatively small. This is probably related to the large structural constraint for DNA binding of the trimeric derivative. The nature of the linking chain for the design of high-affinity DNA poly-intercalating agents appears therefore critical.</description><subject>Acridine</subject><subject>Aminacrine - metabolism</subject><subject>Aminoacridines - metabolism</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cattle</subject><subject>DNA - metabolism</subject><subject>DNA intercalation</subject><subject>Fluorometry</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Interactions. Associations</subject><subject>Intermolecular phenomena</subject><subject>Macromolecular Substances</subject><subject>Molecular biophysics</subject><subject>Poly dA-dT - metabolism</subject><subject>Tris-intercalation</subject><subject>Viscosimetry</subject><subject>Viscosity</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUE1v3CAURFWjdJPmH7SSD1WVHJyCwQZyiJSvbSpF7aU59YAwPFdUXnDA22r_fSC72mPUEzAzb94wCH0g-Jxg0n3BmLC65ZKeCnYmMMVN3b1BCyI4rSnrxFu02EveoaOU_uD8FkQeosOOE8YavEC_br9fVVMYN87PEI0e9eyCv6hMWE06uhR8FYaqiHrnrfO_qymGCeLsIBVG-0qb6DIDlXUriBmx1RzL9T06GPSY4GR3HqPH5d3Pm_v64cfXbzdXD7VpZdPVRIDkjBneD8bQVuRcANBiiWWrObd9O3TAcNtRYocGc2kb3dtmkBQDB07pMfq89c3RntaQZrVyycA4ag9hnRSh2YpyloVsKzQxpBRhUFMOquNGEaxKp6oUpkphSjD10qnq8tjHnf-6X4HdD-1KzPynHa9TbnCI2huX9jIhs4qW7cut7J8bYfNfq9Xy7ropRMEFe0FLnsutEeRS_zqIKhkH3oB1EcysbHCvf-gZD3Sk_Q</recordid><startdate>19840424</startdate><enddate>19840424</enddate><creator>Gaugain, Bernard</creator><creator>Markovits, Judith</creator><creator>Le Pecq, Jean-Bernard</creator><creator>Roques, Bernard P.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope></search><sort><creationdate>19840424</creationdate><title>DNA polyintercalation: comparison of DNA binding properties of an acridine dimer and trimer</title><author>Gaugain, Bernard ; Markovits, Judith ; Le Pecq, Jean-Bernard ; Roques, Bernard P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5926-18e9744c7bfcc358420eee509095a77db5f6e405631df2079d2abd2f930e7e733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Acridine</topic><topic>Aminacrine - metabolism</topic><topic>Aminoacridines - metabolism</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cattle</topic><topic>DNA - metabolism</topic><topic>DNA intercalation</topic><topic>Fluorometry</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Interactions. Associations</topic><topic>Intermolecular phenomena</topic><topic>Macromolecular Substances</topic><topic>Molecular biophysics</topic><topic>Poly dA-dT - metabolism</topic><topic>Tris-intercalation</topic><topic>Viscosimetry</topic><topic>Viscosity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gaugain, Bernard</creatorcontrib><creatorcontrib>Markovits, Judith</creatorcontrib><creatorcontrib>Le Pecq, Jean-Bernard</creatorcontrib><creatorcontrib>Roques, Bernard P.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gaugain, Bernard</au><au>Markovits, Judith</au><au>Le Pecq, Jean-Bernard</au><au>Roques, Bernard P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>DNA polyintercalation: comparison of DNA binding properties of an acridine dimer and trimer</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>1984-04-24</date><risdate>1984</risdate><volume>169</volume><issue>2</issue><spage>123</spage><epage>126</epage><pages>123-126</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><coden>FEBLAL</coden><abstract>The DNA binding characteristics of a mono-, di- and trimeric derivative of 9-aminoacridine were studied. The length of the linking carboxyamidoalkyl chains was selected to allow bis- or tris-intercalation according to the excluded-site model. Measurements of DNA unwinding angle using closed circular DNA showed that the trimeric derivative behaves as a tris-intercalating agent. Nevertheless the increase of DNA binding affinity on going from dimer to trimer was found to be relatively small. This is probably related to the large structural constraint for DNA binding of the trimeric derivative. The nature of the linking chain for the design of high-affinity DNA poly-intercalating agents appears therefore critical.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>6714420</pmid><doi>10.1016/0014-5793(84)80302-6</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-5793 |
| ispartof | FEBS letters, 1984-04, Vol.169 (2), p.123-126 |
| issn | 0014-5793 1873-3468 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_13909374 |
| source | MEDLINE; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Acridine Aminacrine - metabolism Aminoacridines - metabolism Animals Biological and medical sciences Cattle DNA - metabolism DNA intercalation Fluorometry Fundamental and applied biological sciences. Psychology Interactions. Associations Intermolecular phenomena Macromolecular Substances Molecular biophysics Poly dA-dT - metabolism Tris-intercalation Viscosimetry Viscosity |
| title | DNA polyintercalation: comparison of DNA binding properties of an acridine dimer and trimer |
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