Post-irradiation Diethyldithiocarbamate-inhibition of CuZn Superoxide Dismutase Reduces Clonogenic Survival of Chinese Hamster V-79 Cells
Summary The survival of Chinese hamster cells was reduced when they were temporarily treated with diethyldithiocarbamate (DDTC), an efficient inhibitor of CuZn superoxide dismutase (SOD), before radiation exposure. The dose-modifying factor amounted to about 1·3, and was the same for irradiation und...
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| Veröffentlicht in: | International journal of radiation biology 1984, Vol.45 (1), p.11-20 |
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| container_title | International journal of radiation biology |
| container_volume | 45 |
| creator | Westman, Gunnar Midander, Jörgen |
| description | Summary
The survival of Chinese hamster cells was reduced when they were temporarily treated with diethyldithiocarbamate (DDTC), an efficient inhibitor of CuZn superoxide dismutase (SOD), before radiation exposure. The dose-modifying factor amounted to about 1·3, and was the same for irradiation under hypoxic and aerobic conditions. Treatment of the cells with DDTC in the early post-irradiation hours was, however, equally effective. The results suggest that inhibition of CuZn SOD does not enhance the immediate radiation damage, but increases damage in the first hours of the post-irradiation period, possibly through mechanisms interfering with potential lethal damage. |
| doi_str_mv | 10.1080/09553008414550021 |
| format | Article |
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The survival of Chinese hamster cells was reduced when they were temporarily treated with diethyldithiocarbamate (DDTC), an efficient inhibitor of CuZn superoxide dismutase (SOD), before radiation exposure. The dose-modifying factor amounted to about 1·3, and was the same for irradiation under hypoxic and aerobic conditions. Treatment of the cells with DDTC in the early post-irradiation hours was, however, equally effective. The results suggest that inhibition of CuZn SOD does not enhance the immediate radiation damage, but increases damage in the first hours of the post-irradiation period, possibly through mechanisms interfering with potential lethal damage.</description><identifier>ISSN: 0955-3002</identifier><identifier>ISSN: 0020-7616</identifier><identifier>EISSN: 1362-3095</identifier><identifier>DOI: 10.1080/09553008414550021</identifier><identifier>PMID: 6319309</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Aerobiosis ; Anaerobiosis ; Animals ; Cell Survival - drug effects ; Cell Survival - radiation effects ; Clone Cells - drug effects ; Clone Cells - radiation effects ; Cricetinae ; Cricetulus ; Ditiocarb - pharmacology ; Dose-Response Relationship, Drug ; Radiation-Sensitizing Agents - pharmacology ; Superoxide Dismutase - antagonists & inhibitors ; Thiocarbamates - pharmacology ; Time Factors</subject><ispartof>International journal of radiation biology, 1984, Vol.45 (1), p.11-20</ispartof><rights>1984 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1984</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c461t-31529cbba4d3be47f4ee1ebed684ae718b9bae67c8ea7de2e447e73163aeecbe3</citedby><cites>FETCH-LOGICAL-c461t-31529cbba4d3be47f4ee1ebed684ae718b9bae67c8ea7de2e447e73163aeecbe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/09553008414550021$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/09553008414550021$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,776,780,4009,27902,27903,27904,61197,61232,61378,61413</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6319309$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Westman, Gunnar</creatorcontrib><creatorcontrib>Midander, Jörgen</creatorcontrib><title>Post-irradiation Diethyldithiocarbamate-inhibition of CuZn Superoxide Dismutase Reduces Clonogenic Survival of Chinese Hamster V-79 Cells</title><title>International journal of radiation biology</title><addtitle>Int J Radiat Biol Relat Stud Phys Chem Med</addtitle><description>Summary
The survival of Chinese hamster cells was reduced when they were temporarily treated with diethyldithiocarbamate (DDTC), an efficient inhibitor of CuZn superoxide dismutase (SOD), before radiation exposure. The dose-modifying factor amounted to about 1·3, and was the same for irradiation under hypoxic and aerobic conditions. Treatment of the cells with DDTC in the early post-irradiation hours was, however, equally effective. The results suggest that inhibition of CuZn SOD does not enhance the immediate radiation damage, but increases damage in the first hours of the post-irradiation period, possibly through mechanisms interfering with potential lethal damage.</description><subject>Aerobiosis</subject><subject>Anaerobiosis</subject><subject>Animals</subject><subject>Cell Survival - drug effects</subject><subject>Cell Survival - radiation effects</subject><subject>Clone Cells - drug effects</subject><subject>Clone Cells - radiation effects</subject><subject>Cricetinae</subject><subject>Cricetulus</subject><subject>Ditiocarb - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Radiation-Sensitizing Agents - pharmacology</subject><subject>Superoxide Dismutase - antagonists & inhibitors</subject><subject>Thiocarbamates - pharmacology</subject><subject>Time Factors</subject><issn>0955-3002</issn><issn>0020-7616</issn><issn>1362-3095</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9P3DAQxS1UtF0WPkAPlXLqLa0dO__UUxWgVFoJRAsHLtHYmTRGib21nRV8BL41hl1xQeppRnq_9zTzCPnE6FdGK_qN1nnOKa0EE3lOacYOyJLxIkt5VD6Q5Ysed5p9JEfe39O4UV4tyKLgrI7MkjxdWR9S7Rx0GoK2JjnVGIbHsdNh0FaBkzBBwFSbQUv9Stg-aeY7k_yeN-jsg-4wmvw0B_CYXGM3K_RJM1pj_6LRKnJuq7cwvhoHbTBiFzD5gC65Tcs6aXAc_TE57GH0eLKfK3JzfvanuUjXlz9_NT_WqRIFCylneVYrKUF0XKIoe4HIUGJXVAKwZJWsJWBRqgqh7DBDIUosOSs4ICqJfEW-7HI3zv6b0Yd20l7FC8CgnX3LeFXXZZVFkO1A5az3Dvt24_QE7rFltH2pv31Xf_R83ofPcsLuzbHvO-rfd7o2vXUTDAhjGGLL2N7b2Zn4-H_SnwHrWZXX</recordid><startdate>1984</startdate><enddate>1984</enddate><creator>Westman, Gunnar</creator><creator>Midander, Jörgen</creator><general>Informa UK Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>1984</creationdate><title>Post-irradiation Diethyldithiocarbamate-inhibition of CuZn Superoxide Dismutase Reduces Clonogenic Survival of Chinese Hamster V-79 Cells</title><author>Westman, Gunnar ; Midander, Jörgen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c461t-31529cbba4d3be47f4ee1ebed684ae718b9bae67c8ea7de2e447e73163aeecbe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Aerobiosis</topic><topic>Anaerobiosis</topic><topic>Animals</topic><topic>Cell Survival - drug effects</topic><topic>Cell Survival - radiation effects</topic><topic>Clone Cells - drug effects</topic><topic>Clone Cells - radiation effects</topic><topic>Cricetinae</topic><topic>Cricetulus</topic><topic>Ditiocarb - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Radiation-Sensitizing Agents - pharmacology</topic><topic>Superoxide Dismutase - antagonists & inhibitors</topic><topic>Thiocarbamates - pharmacology</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Westman, Gunnar</creatorcontrib><creatorcontrib>Midander, Jörgen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>International journal of radiation biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Westman, Gunnar</au><au>Midander, Jörgen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Post-irradiation Diethyldithiocarbamate-inhibition of CuZn Superoxide Dismutase Reduces Clonogenic Survival of Chinese Hamster V-79 Cells</atitle><jtitle>International journal of radiation biology</jtitle><addtitle>Int J Radiat Biol Relat Stud Phys Chem Med</addtitle><date>1984</date><risdate>1984</risdate><volume>45</volume><issue>1</issue><spage>11</spage><epage>20</epage><pages>11-20</pages><issn>0955-3002</issn><issn>0020-7616</issn><eissn>1362-3095</eissn><abstract>Summary
The survival of Chinese hamster cells was reduced when they were temporarily treated with diethyldithiocarbamate (DDTC), an efficient inhibitor of CuZn superoxide dismutase (SOD), before radiation exposure. The dose-modifying factor amounted to about 1·3, and was the same for irradiation under hypoxic and aerobic conditions. Treatment of the cells with DDTC in the early post-irradiation hours was, however, equally effective. The results suggest that inhibition of CuZn SOD does not enhance the immediate radiation damage, but increases damage in the first hours of the post-irradiation period, possibly through mechanisms interfering with potential lethal damage.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>6319309</pmid><doi>10.1080/09553008414550021</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0955-3002 |
| ispartof | International journal of radiation biology, 1984, Vol.45 (1), p.11-20 |
| issn | 0955-3002 0020-7616 1362-3095 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_13899782 |
| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Aerobiosis Anaerobiosis Animals Cell Survival - drug effects Cell Survival - radiation effects Clone Cells - drug effects Clone Cells - radiation effects Cricetinae Cricetulus Ditiocarb - pharmacology Dose-Response Relationship, Drug Radiation-Sensitizing Agents - pharmacology Superoxide Dismutase - antagonists & inhibitors Thiocarbamates - pharmacology Time Factors |
| title | Post-irradiation Diethyldithiocarbamate-inhibition of CuZn Superoxide Dismutase Reduces Clonogenic Survival of Chinese Hamster V-79 Cells |
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