Synthesis and biological activity of 5-fluoro-2',3'-dideoxy-3'-fluorouridine and its 5'-phosphate

5-Fluoro-2',3'-dideoxy-3'-fluorouridine (3'-FFdUrd) and 5-fluoro-2',3'-dideoxy-3'-fluorouridine 5'-phosphate (3'-FFdUMP) have been synthesized, and their interactions with thymidine (dThd) phosphorylase and thymidylate (dTMP) synthetase, respectively, hav...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of medicinal chemistry 1984-01, Vol.27 (1), p.11-14
Hauptverfasser:	Ajmera, Sudhir, Bapat, Ashok R., Danenberg, Kathleen, Danenberg, Peter V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Division - drug effects Deoxyuracil Nucleotides - chemical synthesis Deoxyuracil Nucleotides - toxicity Dideoxynucleosides Dideoxynucleotides Floxuridine - analogs & derivatives Floxuridine - chemical synthesis Floxuridine - toxicity Indicators and Reagents Kinetics Leukemia L1210 - physiopathology Lung Neoplasms - enzymology Methyltransferases - antagonists & inhibitors Mice Pentosyltransferases - antagonists & inhibitors Thymidine Phosphorylase - antagonists & inhibitors Thymidylate Synthase - antagonists & inhibitors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!