A cytogenetic study on workers exposed to low concentrations of benzene
A cytogenetic study was performed on 22 healthy workers engaged in benzene production and exposed to low concentrations of benzene, ranging from 0.2 to 12.4 p.p.m. (threshold limit value 10 p.p.m.). Workers were divided into two groups according to the different levels of exposure, inferrable also f...
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| Veröffentlicht in: | Carcinogenesis (N.Y.); (United States) 1984-06, Vol.5 (6), p.827-832 |
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| container_title | Carcinogenesis (N.Y.); (United States) |
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| creator | Sarto, F. Cominato, I. Pinton, A.M. Brovedani, P.G. Merier, E. Peruzzi, M. Bianchi, V. Levis, A.G. |
| description | A cytogenetic study was performed on 22 healthy workers engaged in benzene production and exposed to low concentrations of benzene, ranging from 0.2 to 12.4 p.p.m. (threshold limit value 10 p.p.m.). Workers were divided into two groups according to the different levels of exposure, inferrable also from the concentration of benzene in the alveolar air and the levels of urinary phenols. Each exposed subject was paired with a suitable control, living in the same area and of similar smoking habits and age. No statistically significant increase of sister chromatid exchange (SCE) frequency was observed in the exposed groups. In controls, SCE frequency was positively correlated with age and smoking habits. Among structural chromosomal aberrations, only the chromosome-type ones were significantly higher in exposed than in control subjects, and their increase was still significant when gaps were discarded. |
| doi_str_mv | 10.1093/carcin/5.6.827 |
| format | Article |
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Workers were divided into two groups according to the different levels of exposure, inferrable also from the concentration of benzene in the alveolar air and the levels of urinary phenols. Each exposed subject was paired with a suitable control, living in the same area and of similar smoking habits and age. No statistically significant increase of sister chromatid exchange (SCE) frequency was observed in the exposed groups. In controls, SCE frequency was positively correlated with age and smoking habits. Among structural chromosomal aberrations, only the chromosome-type ones were significantly higher in exposed than in control subjects, and their increase was still significant when gaps were discarded.</description><identifier>ISSN: 0143-3334</identifier><identifier>EISSN: 1460-2180</identifier><identifier>DOI: 10.1093/carcin/5.6.827</identifier><identifier>PMID: 6722989</identifier><identifier>CODEN: CRNGDP</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>560306 - Chemicals Metabolism & Toxicology- Man- (-1987) ; Adult ; AEROSOLS ; AGE DEPENDENCE ; Age Factors ; Air Pollutants, Occupational - analysis ; Air Pollutants, Occupational - toxicity ; AIR POLLUTION ; ANIMAL CELLS ; AROMATICS ; BENZENE ; Benzene - analysis ; Benzene - toxicity ; BIOLOGICAL ACCUMULATION ; Biological and medical sciences ; BIOLOGICAL EFFECTS ; BIOLOGICAL MATERIALS ; BIOLOGICAL WASTES ; BODY FLUIDS ; Cells, Cultured ; CHEMICAL ANALYSIS ; Chemical mutagenesis ; CHROMOSOMAL ABERRATIONS ; CLEARANCE ; COLLOIDS ; Crossing Over, Genetic - drug effects ; DISPERSIONS ; Environmental Pollutants - toxicity ; EXCRETION ; EXHALATION ; GENETIC EFFECTS ; Humans ; HYDROCARBONS ; HYDROXY COMPOUNDS ; Male ; MATERIALS ; Medical sciences ; Metaphase - drug effects ; Middle Aged ; MUTATIONS ; OCCUPATIONAL EXPOSURE ; ORGANIC COMPOUNDS ; PHENOLS ; POLLUTION ; Pulmonary Alveoli - analysis ; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT ; RESIDUES ; Sister Chromatid Exchange - drug effects ; SISTER CHROMATID EXCHANGES ; SMOKES ; Smoking ; SOLS ; Time Factors ; TOBACCO SMOKES ; Toxicology ; URINE ; WASTES</subject><ispartof>Carcinogenesis (N.Y.); (United States), 1984-06, Vol.5 (6), p.827-832</ispartof><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-ce57e0ea0a10626f8ebe78e9ad29f68eba5020c72e39f2f022fbf49d78853b183</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,885,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8885161$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6722989$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/6536671$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Sarto, F.</creatorcontrib><creatorcontrib>Cominato, I.</creatorcontrib><creatorcontrib>Pinton, A.M.</creatorcontrib><creatorcontrib>Brovedani, P.G.</creatorcontrib><creatorcontrib>Merier, E.</creatorcontrib><creatorcontrib>Peruzzi, M.</creatorcontrib><creatorcontrib>Bianchi, V.</creatorcontrib><creatorcontrib>Levis, A.G.</creatorcontrib><creatorcontrib>Universita di Padova, Padua, Italy</creatorcontrib><title>A cytogenetic study on workers exposed to low concentrations of benzene</title><title>Carcinogenesis (N.Y.); (United States)</title><addtitle>Carcinogenesis</addtitle><description>A cytogenetic study was performed on 22 healthy workers engaged in benzene production and exposed to low concentrations of benzene, ranging from 0.2 to 12.4 p.p.m. (threshold limit value 10 p.p.m.). Workers were divided into two groups according to the different levels of exposure, inferrable also from the concentration of benzene in the alveolar air and the levels of urinary phenols. Each exposed subject was paired with a suitable control, living in the same area and of similar smoking habits and age. No statistically significant increase of sister chromatid exchange (SCE) frequency was observed in the exposed groups. In controls, SCE frequency was positively correlated with age and smoking habits. Among structural chromosomal aberrations, only the chromosome-type ones were significantly higher in exposed than in control subjects, and their increase was still significant when gaps were discarded.</description><subject>560306 - Chemicals Metabolism & Toxicology- Man- (-1987)</subject><subject>Adult</subject><subject>AEROSOLS</subject><subject>AGE DEPENDENCE</subject><subject>Age Factors</subject><subject>Air Pollutants, Occupational - analysis</subject><subject>Air Pollutants, Occupational - toxicity</subject><subject>AIR POLLUTION</subject><subject>ANIMAL CELLS</subject><subject>AROMATICS</subject><subject>BENZENE</subject><subject>Benzene - analysis</subject><subject>Benzene - toxicity</subject><subject>BIOLOGICAL ACCUMULATION</subject><subject>Biological and medical sciences</subject><subject>BIOLOGICAL EFFECTS</subject><subject>BIOLOGICAL MATERIALS</subject><subject>BIOLOGICAL WASTES</subject><subject>BODY FLUIDS</subject><subject>Cells, Cultured</subject><subject>CHEMICAL ANALYSIS</subject><subject>Chemical mutagenesis</subject><subject>CHROMOSOMAL ABERRATIONS</subject><subject>CLEARANCE</subject><subject>COLLOIDS</subject><subject>Crossing Over, Genetic - drug effects</subject><subject>DISPERSIONS</subject><subject>Environmental Pollutants - toxicity</subject><subject>EXCRETION</subject><subject>EXHALATION</subject><subject>GENETIC EFFECTS</subject><subject>Humans</subject><subject>HYDROCARBONS</subject><subject>HYDROXY COMPOUNDS</subject><subject>Male</subject><subject>MATERIALS</subject><subject>Medical sciences</subject><subject>Metaphase - drug effects</subject><subject>Middle Aged</subject><subject>MUTATIONS</subject><subject>OCCUPATIONAL EXPOSURE</subject><subject>ORGANIC COMPOUNDS</subject><subject>PHENOLS</subject><subject>POLLUTION</subject><subject>Pulmonary Alveoli - analysis</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</subject><subject>RESIDUES</subject><subject>Sister Chromatid Exchange - drug effects</subject><subject>SISTER CHROMATID EXCHANGES</subject><subject>SMOKES</subject><subject>Smoking</subject><subject>SOLS</subject><subject>Time Factors</subject><subject>TOBACCO SMOKES</subject><subject>Toxicology</subject><subject>URINE</subject><subject>WASTES</subject><issn>0143-3334</issn><issn>1460-2180</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kN9rFDEQx4Mo9Vp99U0IIn3ba35sssljKdoqBUEqii8hm51o7F5yJjna8683ZY97mhm-n_ky80XoDSVrSjS_cDa7EC_EWq4VG56hFe0l6RhV5DlaEdrzjnPev0SnpfwhhEou9Ak6kQNjWukVur7Ebl_TL4hQg8Ol7qY9ThE_pHwPuWB43KYCE64Jz-kBuxQdxJptDSkWnDweIf5ry6_QC2_nAq8P9Qx9-_jh7uqmu_1y_enq8rZzvaK1cyAGIGCJpUQy6RWMMCjQdmLayzZZQRhxAwOuPfOEMT_6Xk-DUoKPVPEz9G7xTaUGU1yo4H63qyK4aqTgUg60QecLtM3p7w5KNZtQHMyzjZB2xVCuNBVUN3C9gC6nUjJ4s81hY_PeUGKe4jVLvEYYaVq8beHtwXk3bmA64oc8m_7-oNvi7OyzjS6UI6baG1Q-HdgtWCgVHo-yzffNiQ_C3Pz4aSS_-yo-k--t-Q9DMpMG</recordid><startdate>198406</startdate><enddate>198406</enddate><creator>Sarto, F.</creator><creator>Cominato, I.</creator><creator>Pinton, A.M.</creator><creator>Brovedani, P.G.</creator><creator>Merier, E.</creator><creator>Peruzzi, M.</creator><creator>Bianchi, V.</creator><creator>Levis, A.G.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>OTOTI</scope></search><sort><creationdate>198406</creationdate><title>A cytogenetic study on workers exposed to low concentrations of benzene</title><author>Sarto, F. ; Cominato, I. ; Pinton, A.M. ; Brovedani, P.G. ; Merier, E. ; Peruzzi, M. ; Bianchi, V. ; Levis, A.G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-ce57e0ea0a10626f8ebe78e9ad29f68eba5020c72e39f2f022fbf49d78853b183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>560306 - Chemicals Metabolism & Toxicology- Man- (-1987)</topic><topic>Adult</topic><topic>AEROSOLS</topic><topic>AGE DEPENDENCE</topic><topic>Age Factors</topic><topic>Air Pollutants, Occupational - analysis</topic><topic>Air Pollutants, Occupational - toxicity</topic><topic>AIR POLLUTION</topic><topic>ANIMAL CELLS</topic><topic>AROMATICS</topic><topic>BENZENE</topic><topic>Benzene - analysis</topic><topic>Benzene - toxicity</topic><topic>BIOLOGICAL ACCUMULATION</topic><topic>Biological and medical sciences</topic><topic>BIOLOGICAL EFFECTS</topic><topic>BIOLOGICAL MATERIALS</topic><topic>BIOLOGICAL WASTES</topic><topic>BODY FLUIDS</topic><topic>Cells, Cultured</topic><topic>CHEMICAL ANALYSIS</topic><topic>Chemical mutagenesis</topic><topic>CHROMOSOMAL ABERRATIONS</topic><topic>CLEARANCE</topic><topic>COLLOIDS</topic><topic>Crossing Over, Genetic - drug effects</topic><topic>DISPERSIONS</topic><topic>Environmental Pollutants - toxicity</topic><topic>EXCRETION</topic><topic>EXHALATION</topic><topic>GENETIC EFFECTS</topic><topic>Humans</topic><topic>HYDROCARBONS</topic><topic>HYDROXY COMPOUNDS</topic><topic>Male</topic><topic>MATERIALS</topic><topic>Medical sciences</topic><topic>Metaphase - drug effects</topic><topic>Middle Aged</topic><topic>MUTATIONS</topic><topic>OCCUPATIONAL EXPOSURE</topic><topic>ORGANIC COMPOUNDS</topic><topic>PHENOLS</topic><topic>POLLUTION</topic><topic>Pulmonary Alveoli - analysis</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</topic><topic>RESIDUES</topic><topic>Sister Chromatid Exchange - drug effects</topic><topic>SISTER CHROMATID EXCHANGES</topic><topic>SMOKES</topic><topic>Smoking</topic><topic>SOLS</topic><topic>Time Factors</topic><topic>TOBACCO SMOKES</topic><topic>Toxicology</topic><topic>URINE</topic><topic>WASTES</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sarto, F.</creatorcontrib><creatorcontrib>Cominato, I.</creatorcontrib><creatorcontrib>Pinton, A.M.</creatorcontrib><creatorcontrib>Brovedani, P.G.</creatorcontrib><creatorcontrib>Merier, E.</creatorcontrib><creatorcontrib>Peruzzi, M.</creatorcontrib><creatorcontrib>Bianchi, V.</creatorcontrib><creatorcontrib>Levis, A.G.</creatorcontrib><creatorcontrib>Universita di Padova, Padua, Italy</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>OSTI.GOV</collection><jtitle>Carcinogenesis (N.Y.); (United States)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sarto, F.</au><au>Cominato, I.</au><au>Pinton, A.M.</au><au>Brovedani, P.G.</au><au>Merier, E.</au><au>Peruzzi, M.</au><au>Bianchi, V.</au><au>Levis, A.G.</au><aucorp>Universita di Padova, Padua, Italy</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A cytogenetic study on workers exposed to low concentrations of benzene</atitle><jtitle>Carcinogenesis (N.Y.); (United States)</jtitle><addtitle>Carcinogenesis</addtitle><date>1984-06</date><risdate>1984</risdate><volume>5</volume><issue>6</issue><spage>827</spage><epage>832</epage><pages>827-832</pages><issn>0143-3334</issn><eissn>1460-2180</eissn><coden>CRNGDP</coden><abstract>A cytogenetic study was performed on 22 healthy workers engaged in benzene production and exposed to low concentrations of benzene, ranging from 0.2 to 12.4 p.p.m. (threshold limit value 10 p.p.m.). Workers were divided into two groups according to the different levels of exposure, inferrable also from the concentration of benzene in the alveolar air and the levels of urinary phenols. Each exposed subject was paired with a suitable control, living in the same area and of similar smoking habits and age. No statistically significant increase of sister chromatid exchange (SCE) frequency was observed in the exposed groups. In controls, SCE frequency was positively correlated with age and smoking habits. Among structural chromosomal aberrations, only the chromosome-type ones were significantly higher in exposed than in control subjects, and their increase was still significant when gaps were discarded.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>6722989</pmid><doi>10.1093/carcin/5.6.827</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0143-3334 |
| ispartof | Carcinogenesis (N.Y.); (United States), 1984-06, Vol.5 (6), p.827-832 |
| issn | 0143-3334 1460-2180 |
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| recordid | cdi_proquest_miscellaneous_13891519 |
| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy |
| subjects | 560306 - Chemicals Metabolism & Toxicology- Man- (-1987) Adult AEROSOLS AGE DEPENDENCE Age Factors Air Pollutants, Occupational - analysis Air Pollutants, Occupational - toxicity AIR POLLUTION ANIMAL CELLS AROMATICS BENZENE Benzene - analysis Benzene - toxicity BIOLOGICAL ACCUMULATION Biological and medical sciences BIOLOGICAL EFFECTS BIOLOGICAL MATERIALS BIOLOGICAL WASTES BODY FLUIDS Cells, Cultured CHEMICAL ANALYSIS Chemical mutagenesis CHROMOSOMAL ABERRATIONS CLEARANCE COLLOIDS Crossing Over, Genetic - drug effects DISPERSIONS Environmental Pollutants - toxicity EXCRETION EXHALATION GENETIC EFFECTS Humans HYDROCARBONS HYDROXY COMPOUNDS Male MATERIALS Medical sciences Metaphase - drug effects Middle Aged MUTATIONS OCCUPATIONAL EXPOSURE ORGANIC COMPOUNDS PHENOLS POLLUTION Pulmonary Alveoli - analysis RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RESIDUES Sister Chromatid Exchange - drug effects SISTER CHROMATID EXCHANGES SMOKES Smoking SOLS Time Factors TOBACCO SMOKES Toxicology URINE WASTES |
| title | A cytogenetic study on workers exposed to low concentrations of benzene |
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