Mutagenicity of extracts of some vegetables commonly consumed in the Netherlands
An assessment was made of the mutagenic properties of six vegetables commonly consumed in the Netherlands. Extracts were screened in the Salmonella typhimurium strains TA98, TA100, and TA1537 by using the standard protocol. In addition, extracts of the gut flora (GFE) of rats were used as a metaboli...
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| Veröffentlicht in: | Journal of agricultural and food chemistry 1983-09, Vol.31 (5), p.1020-1026 |
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| container_end_page | 1026 |
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| container_issue | 5 |
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| container_title | Journal of agricultural and food chemistry |
| container_volume | 31 |
| creator | Van der Hoeven, Jan C Lagerweij, Willy J Bruggeman, Irene M Voragen, Fons G Koeman, Jan H |
| description | An assessment was made of the mutagenic properties of six vegetables commonly consumed in the Netherlands. Extracts were screened in the Salmonella typhimurium strains TA98, TA100, and TA1537 by using the standard protocol. In addition, extracts of the gut flora (GFE) of rats were used as a metabolizing system. In total 27 cultivars grown under known and identical conditions were tested. Cultivars of lettuce, paprika, and rhubarb were mutagenic in TA98 in the presence of GFE. String beans were mutagenic in TA98 and TA100 with GFE. Rhubarb was also mutagenic in TA1537 when tested with liver homogenate. Spinach and Brussels sprouts were found negative. The mutagenic vegetables showed marked intercultivar variations with respect to their mutagenic properties. Evidence is obtained that querectin glycosides are mainly responsible for the mutagenicity of lettuce and string beans. The mutagenicity of rhubarb in TA1537 is caused by emodin. |
| doi_str_mv | 10.1021/jf00119a025 |
| format | Article |
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Extracts were screened in the Salmonella typhimurium strains TA98, TA100, and TA1537 by using the standard protocol. In addition, extracts of the gut flora (GFE) of rats were used as a metabolizing system. In total 27 cultivars grown under known and identical conditions were tested. Cultivars of lettuce, paprika, and rhubarb were mutagenic in TA98 in the presence of GFE. String beans were mutagenic in TA98 and TA100 with GFE. Rhubarb was also mutagenic in TA1537 when tested with liver homogenate. Spinach and Brussels sprouts were found negative. The mutagenic vegetables showed marked intercultivar variations with respect to their mutagenic properties. Evidence is obtained that querectin glycosides are mainly responsible for the mutagenicity of lettuce and string beans. The mutagenicity of rhubarb in TA1537 is caused by emodin.</description><identifier>ISSN: 0021-8561</identifier><identifier>EISSN: 1520-5118</identifier><identifier>DOI: 10.1021/jf00119a025</identifier><identifier>PMID: 6355227</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Animals ; Cecum - microbiology ; Female ; Liver - drug effects ; Mutagenicity Tests ; Mutagens ; Netherlands ; Plant Extracts - toxicity ; Rats ; Salmonella typhimurium - drug effects ; Species Specificity ; Vegetables - adverse effects</subject><ispartof>Journal of agricultural and food chemistry, 1983-09, Vol.31 (5), p.1020-1026</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a404t-8cffde0a383c3bf5ff6e4e11f81ab9c9a30e05496e6ac3c23e210ae4907c97833</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/jf00119a025$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/jf00119a025$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6355227$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Van der Hoeven, Jan C</creatorcontrib><creatorcontrib>Lagerweij, Willy J</creatorcontrib><creatorcontrib>Bruggeman, Irene M</creatorcontrib><creatorcontrib>Voragen, Fons G</creatorcontrib><creatorcontrib>Koeman, Jan H</creatorcontrib><title>Mutagenicity of extracts of some vegetables commonly consumed in the Netherlands</title><title>Journal of agricultural and food chemistry</title><addtitle>J. Agric. Food Chem</addtitle><description>An assessment was made of the mutagenic properties of six vegetables commonly consumed in the Netherlands. Extracts were screened in the Salmonella typhimurium strains TA98, TA100, and TA1537 by using the standard protocol. In addition, extracts of the gut flora (GFE) of rats were used as a metabolizing system. In total 27 cultivars grown under known and identical conditions were tested. Cultivars of lettuce, paprika, and rhubarb were mutagenic in TA98 in the presence of GFE. String beans were mutagenic in TA98 and TA100 with GFE. Rhubarb was also mutagenic in TA1537 when tested with liver homogenate. Spinach and Brussels sprouts were found negative. The mutagenic vegetables showed marked intercultivar variations with respect to their mutagenic properties. Evidence is obtained that querectin glycosides are mainly responsible for the mutagenicity of lettuce and string beans. The mutagenicity of rhubarb in TA1537 is caused by emodin.</description><subject>Animals</subject><subject>Cecum - microbiology</subject><subject>Female</subject><subject>Liver - drug effects</subject><subject>Mutagenicity Tests</subject><subject>Mutagens</subject><subject>Netherlands</subject><subject>Plant Extracts - toxicity</subject><subject>Rats</subject><subject>Salmonella typhimurium - drug effects</subject><subject>Species Specificity</subject><subject>Vegetables - adverse effects</subject><issn>0021-8561</issn><issn>1520-5118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkE1r3DAQhkVpSDYfp94KBZ-SQ3E6sixZOoa0TQJpGsimV6HVjjbe2lYiySX776vFS-ihl5mB52GYeQn5QOGcQkW_rB0ApcpAxd-RGeUVlJxS-Z7MIONSckEPyGGMawCQvIF9si8Y51XVzMj9jzGZFQ6tbdOm8K7A1xSMTXE7R99j8QdXmMyiw1hY3_d-6DZ5GOLY47JohyI9YXGHuYbODMt4TPac6SKe7PoRefz-bX55Xd7-vLq5vLgtTQ11KqV1bolgmGSWLRx3TmCNlDpJzUJZZRgg8FoJFMYyWzGsKBisFTRWNZKxI3I67X0O_mXEmHTfRotdPgL9GDVlUqiaqyx-nkQbfIwBnX4ObW_CRlPQ2_z0P_ll-9Nu7bjID765u8AyLyfexoSvb9iE31o0rOF6fv-g-fXVr0Z8neut_3HynfHarEIb9eODrBQXTGR4NkFjo177MQw5sf-e9Rdyho84</recordid><startdate>198309</startdate><enddate>198309</enddate><creator>Van der Hoeven, Jan C</creator><creator>Lagerweij, Willy J</creator><creator>Bruggeman, Irene M</creator><creator>Voragen, Fons G</creator><creator>Koeman, Jan H</creator><general>American Chemical Society</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>198309</creationdate><title>Mutagenicity of extracts of some vegetables commonly consumed in the Netherlands</title><author>Van der Hoeven, Jan C ; Lagerweij, Willy J ; Bruggeman, Irene M ; Voragen, Fons G ; Koeman, Jan H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a404t-8cffde0a383c3bf5ff6e4e11f81ab9c9a30e05496e6ac3c23e210ae4907c97833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Animals</topic><topic>Cecum - microbiology</topic><topic>Female</topic><topic>Liver - drug effects</topic><topic>Mutagenicity Tests</topic><topic>Mutagens</topic><topic>Netherlands</topic><topic>Plant Extracts - toxicity</topic><topic>Rats</topic><topic>Salmonella typhimurium - drug effects</topic><topic>Species Specificity</topic><topic>Vegetables - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Van der Hoeven, Jan C</creatorcontrib><creatorcontrib>Lagerweij, Willy J</creatorcontrib><creatorcontrib>Bruggeman, Irene M</creatorcontrib><creatorcontrib>Voragen, Fons G</creatorcontrib><creatorcontrib>Koeman, Jan H</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Journal of agricultural and food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Van der Hoeven, Jan C</au><au>Lagerweij, Willy J</au><au>Bruggeman, Irene M</au><au>Voragen, Fons G</au><au>Koeman, Jan H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mutagenicity of extracts of some vegetables commonly consumed in the Netherlands</atitle><jtitle>Journal of agricultural and food chemistry</jtitle><addtitle>J. Agric. Food Chem</addtitle><date>1983-09</date><risdate>1983</risdate><volume>31</volume><issue>5</issue><spage>1020</spage><epage>1026</epage><pages>1020-1026</pages><issn>0021-8561</issn><eissn>1520-5118</eissn><abstract>An assessment was made of the mutagenic properties of six vegetables commonly consumed in the Netherlands. Extracts were screened in the Salmonella typhimurium strains TA98, TA100, and TA1537 by using the standard protocol. In addition, extracts of the gut flora (GFE) of rats were used as a metabolizing system. In total 27 cultivars grown under known and identical conditions were tested. Cultivars of lettuce, paprika, and rhubarb were mutagenic in TA98 in the presence of GFE. String beans were mutagenic in TA98 and TA100 with GFE. Rhubarb was also mutagenic in TA1537 when tested with liver homogenate. Spinach and Brussels sprouts were found negative. The mutagenic vegetables showed marked intercultivar variations with respect to their mutagenic properties. Evidence is obtained that querectin glycosides are mainly responsible for the mutagenicity of lettuce and string beans. The mutagenicity of rhubarb in TA1537 is caused by emodin.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>6355227</pmid><doi>10.1021/jf00119a025</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0021-8561 |
| ispartof | Journal of agricultural and food chemistry, 1983-09, Vol.31 (5), p.1020-1026 |
| issn | 0021-8561 1520-5118 |
| language | eng |
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| source | ACS Publications; MEDLINE |
| subjects | Animals Cecum - microbiology Female Liver - drug effects Mutagenicity Tests Mutagens Netherlands Plant Extracts - toxicity Rats Salmonella typhimurium - drug effects Species Specificity Vegetables - adverse effects |
| title | Mutagenicity of extracts of some vegetables commonly consumed in the Netherlands |
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