The role of hepatic biotransformation in mediating the acute toxicity of the phosphorothionate insecticide chlorpyrifos

The apparent (app) K m and app V max for mouse hepatic microsomal oxidative detoxification of chlorpyrifos to 3,5,6-tricholoro-2-pyridinol were 16.10 ± 6.8 μ m and 263.2 ± 22.5 nmol/liver/min, respectively. The app K m and app V max for the osidative activation of chlorpyrifos to chlorpyrifos oxon w...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Toxicology and applied pharmacology 1984-01, Vol.73 (1), p.60-68
Hauptverfasser:	Sultatos, Lester G., Shao, M., Murphy, S.D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzoflavones - pharmacology beta-Naphthoflavone Biological and medical sciences Biotransformation Chlorpyrifos - analogs & derivatives Chlorpyrifos - metabolism Chlorpyrifos - toxicity Hydrolysis In Vitro Techniques Inactivation, Metabolic Kinetics Male Medical sciences Metabolic Clearance Rate Mice Microsomes, Liver - metabolism Oxidation-Reduction Pesticides, fertilizers and other agrochemicals toxicology Phenobarbital - pharmacology Toxicology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!