Preclinical toxicology studies with acyclovir: Teratologic, reproductive and neonatal tests

Five studies were done to define the potential of Acyclovir (ACV), a new nucleoside analog for antiviral chemotherapy, to produce adverse effects on reproduction and development in laboratory animals. ACV produced no adverse effects when given by gavage to F o generation mice at 50, 150 and 450 mg/k...

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Veröffentlicht in:	Fundamental and applied toxicology 1983-11, Vol.3 (6), p.560-568
Hauptverfasser:	Moore, Hall L., Szczech, George M., Rodwell, Dean E., Kapp, Robert W., de Miranda, Paulo, Tucker, Walter E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities, Drug-Induced - etiology Acyclovir - metabolism Acyclovir - toxicity Animals Animals, Newborn Brain - drug effects Female Kidney - drug effects Lethal Dose 50 Male Mice Mice, Inbred Strains Pregnancy Rabbits Rats Reproduction - drug effects
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