Effect of acute cocaine administration on the metabolism of antipyrine in vivo
The intent of this study was to determine a physiological, in vivo correlate to the existing biochemical data on acute cocaine-induced hepatotoxicity in a non-induced mouse strain. The authors report that a single injection of cocaine produced a dramatic decrease in hepatic cytochrome P-450 content...
Gespeichert in:
| Veröffentlicht in: | Biochemical pharmacology 1983-12, Vol.32 (24), p.3871-3873 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 3873 |
|---|---|
| container_issue | 24 |
| container_start_page | 3871 |
| container_title | Biochemical pharmacology |
| container_volume | 32 |
| creator | Kloss, Michelle W. Griffeth, Landis K. Rosen, Gerald M. Rauckman, Elmer J. |
| description | The intent of this study was to determine a physiological, in vivo correlate to the existing biochemical data on acute cocaine-induced hepatotoxicity in a non-induced mouse strain. The authors report that a single injection of cocaine produced a dramatic decrease in hepatic cytochrome P-450 content and a correspondingly marked depression of in vivo hepatic antipyrine metabolism in non-induced mice. It is suggested that cocaine administration may likewise alter the hepatic metabolism of a wide variety of xenobiotics and, in doing so, may alter the therapeutics and toxicity of these drugs. |
| doi_str_mv | 10.1016/0006-2952(83)90165-X |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_13830960</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>000629528390165X</els_id><sourcerecordid>13830960</sourcerecordid><originalsourceid>FETCH-LOGICAL-c281t-fb406b6682f002a93f5bc2542782ee508ef701e1ba96992480ccc1d179013f643</originalsourceid><addsrcrecordid>eNp9kF1LwzAUhoMoc07_gUIvRPSimqRtmt4IMuYHDL1R2F1I0xOMtM1MssH-vek2dikEQs553sPJg9AlwfcEE_aAMWYprQp6y7O7KlaKdHGExoSXWSwzfozGB-QUnXn_Mzw5IyM0YowRysgYvc-0BhUSqxOpVgESZZU0PSSy6UxvfHAyGNsn8YRvSDoIsrat8d020Qez3LgBN32yNmt7jk60bD1c7O8J-nqefU5f0_nHy9v0aZ4qyklIdZ1jVjPGqcaYyirTRa1okdOSU4ACc9AlJkBqWbGqojnHSinSkDJ-M9MszyboZjd36ezvCnwQnfEK2lb2YFdekIxnuGI4gvkOVM5670CLpTOddBtBsBg0ikGKGBwJnomtRrGIsav9_FXdQXMI7b3F_vW-L72SrXayV8YfsKokBSsH7HGHQXSxNuCEVwZ6BY1x0bporPl_jz9U7Y1-</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>13830960</pqid></control><display><type>article</type><title>Effect of acute cocaine administration on the metabolism of antipyrine in vivo</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Kloss, Michelle W. ; Griffeth, Landis K. ; Rosen, Gerald M. ; Rauckman, Elmer J.</creator><creatorcontrib>Kloss, Michelle W. ; Griffeth, Landis K. ; Rosen, Gerald M. ; Rauckman, Elmer J.</creatorcontrib><description>The intent of this study was to determine a physiological, in vivo correlate to the existing biochemical data on acute cocaine-induced hepatotoxicity in a non-induced mouse strain. The authors report that a single injection of cocaine produced a dramatic decrease in hepatic cytochrome P-450 content and a correspondingly marked depression of in vivo hepatic antipyrine metabolism in non-induced mice. It is suggested that cocaine administration may likewise alter the hepatic metabolism of a wide variety of xenobiotics and, in doing so, may alter the therapeutics and toxicity of these drugs.</description><identifier>ISSN: 0006-2952</identifier><identifier>EISSN: 1873-2968</identifier><identifier>DOI: 10.1016/0006-2952(83)90165-X</identifier><identifier>PMID: 6661261</identifier><identifier>CODEN: BCPCA6</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Antipyrine - metabolism ; Biological and medical sciences ; Chemical and Drug Induced Liver Injury - metabolism ; Cocaine - pharmacology ; Cytochrome P-450 Enzyme System - metabolism ; Liver - metabolism ; Male ; Medical sciences ; Mice ; Mice, Inbred DBA ; Neuropharmacology ; Pharmacology. Drug treatments ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. Psychiatry ; Psychopharmacology</subject><ispartof>Biochemical pharmacology, 1983-12, Vol.32 (24), p.3871-3873</ispartof><rights>1983</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c281t-fb406b6682f002a93f5bc2542782ee508ef701e1ba96992480ccc1d179013f643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-2952(83)90165-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9715671$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6661261$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kloss, Michelle W.</creatorcontrib><creatorcontrib>Griffeth, Landis K.</creatorcontrib><creatorcontrib>Rosen, Gerald M.</creatorcontrib><creatorcontrib>Rauckman, Elmer J.</creatorcontrib><title>Effect of acute cocaine administration on the metabolism of antipyrine in vivo</title><title>Biochemical pharmacology</title><addtitle>Biochem Pharmacol</addtitle><description>The intent of this study was to determine a physiological, in vivo correlate to the existing biochemical data on acute cocaine-induced hepatotoxicity in a non-induced mouse strain. The authors report that a single injection of cocaine produced a dramatic decrease in hepatic cytochrome P-450 content and a correspondingly marked depression of in vivo hepatic antipyrine metabolism in non-induced mice. It is suggested that cocaine administration may likewise alter the hepatic metabolism of a wide variety of xenobiotics and, in doing so, may alter the therapeutics and toxicity of these drugs.</description><subject>Animals</subject><subject>Antipyrine - metabolism</subject><subject>Biological and medical sciences</subject><subject>Chemical and Drug Induced Liver Injury - metabolism</subject><subject>Cocaine - pharmacology</subject><subject>Cytochrome P-450 Enzyme System - metabolism</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred DBA</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><issn>0006-2952</issn><issn>1873-2968</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1LwzAUhoMoc07_gUIvRPSimqRtmt4IMuYHDL1R2F1I0xOMtM1MssH-vek2dikEQs553sPJg9AlwfcEE_aAMWYprQp6y7O7KlaKdHGExoSXWSwzfozGB-QUnXn_Mzw5IyM0YowRysgYvc-0BhUSqxOpVgESZZU0PSSy6UxvfHAyGNsn8YRvSDoIsrat8d020Qez3LgBN32yNmt7jk60bD1c7O8J-nqefU5f0_nHy9v0aZ4qyklIdZ1jVjPGqcaYyirTRa1okdOSU4ACc9AlJkBqWbGqojnHSinSkDJ-M9MszyboZjd36ezvCnwQnfEK2lb2YFdekIxnuGI4gvkOVM5670CLpTOddBtBsBg0ikGKGBwJnomtRrGIsav9_FXdQXMI7b3F_vW-L72SrXayV8YfsKokBSsH7HGHQXSxNuCEVwZ6BY1x0bporPl_jz9U7Y1-</recordid><startdate>19831215</startdate><enddate>19831215</enddate><creator>Kloss, Michelle W.</creator><creator>Griffeth, Landis K.</creator><creator>Rosen, Gerald M.</creator><creator>Rauckman, Elmer J.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19831215</creationdate><title>Effect of acute cocaine administration on the metabolism of antipyrine in vivo</title><author>Kloss, Michelle W. ; Griffeth, Landis K. ; Rosen, Gerald M. ; Rauckman, Elmer J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c281t-fb406b6682f002a93f5bc2542782ee508ef701e1ba96992480ccc1d179013f643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Animals</topic><topic>Antipyrine - metabolism</topic><topic>Biological and medical sciences</topic><topic>Chemical and Drug Induced Liver Injury - metabolism</topic><topic>Cocaine - pharmacology</topic><topic>Cytochrome P-450 Enzyme System - metabolism</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred DBA</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kloss, Michelle W.</creatorcontrib><creatorcontrib>Griffeth, Landis K.</creatorcontrib><creatorcontrib>Rosen, Gerald M.</creatorcontrib><creatorcontrib>Rauckman, Elmer J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Biochemical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kloss, Michelle W.</au><au>Griffeth, Landis K.</au><au>Rosen, Gerald M.</au><au>Rauckman, Elmer J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of acute cocaine administration on the metabolism of antipyrine in vivo</atitle><jtitle>Biochemical pharmacology</jtitle><addtitle>Biochem Pharmacol</addtitle><date>1983-12-15</date><risdate>1983</risdate><volume>32</volume><issue>24</issue><spage>3871</spage><epage>3873</epage><pages>3871-3873</pages><issn>0006-2952</issn><eissn>1873-2968</eissn><coden>BCPCA6</coden><abstract>The intent of this study was to determine a physiological, in vivo correlate to the existing biochemical data on acute cocaine-induced hepatotoxicity in a non-induced mouse strain. The authors report that a single injection of cocaine produced a dramatic decrease in hepatic cytochrome P-450 content and a correspondingly marked depression of in vivo hepatic antipyrine metabolism in non-induced mice. It is suggested that cocaine administration may likewise alter the hepatic metabolism of a wide variety of xenobiotics and, in doing so, may alter the therapeutics and toxicity of these drugs.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>6661261</pmid><doi>10.1016/0006-2952(83)90165-X</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-2952 |
| ispartof | Biochemical pharmacology, 1983-12, Vol.32 (24), p.3871-3873 |
| issn | 0006-2952 1873-2968 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_13830960 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Antipyrine - metabolism Biological and medical sciences Chemical and Drug Induced Liver Injury - metabolism Cocaine - pharmacology Cytochrome P-450 Enzyme System - metabolism Liver - metabolism Male Medical sciences Mice Mice, Inbred DBA Neuropharmacology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology |
| title | Effect of acute cocaine administration on the metabolism of antipyrine in vivo |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T00%3A09%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20acute%20cocaine%20administration%20on%20the%20metabolism%20of%20antipyrine%20in%20vivo&rft.jtitle=Biochemical%20pharmacology&rft.au=Kloss,%20Michelle%20W.&rft.date=1983-12-15&rft.volume=32&rft.issue=24&rft.spage=3871&rft.epage=3873&rft.pages=3871-3873&rft.issn=0006-2952&rft.eissn=1873-2968&rft.coden=BCPCA6&rft_id=info:doi/10.1016/0006-2952(83)90165-X&rft_dat=%3Cproquest_cross%3E13830960%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=13830960&rft_id=info:pmid/6661261&rft_els_id=000629528390165X&rfr_iscdi=true |