Hemoperfusion in theophylline neurotoxicity
Four patients with severe theophylline toxicity (theophylline levels of 60 to 180 micrograms/ml) are reported. Three patients with neurotoxicity were treated with hemoperfusion. Two of these were hemoperfused early after the onset of seizures; they recovered with no neurologic deficit. In the third...
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| Veröffentlicht in: | Pediatrics (Evanston) 1983-04, Vol.71 (4), p.615-619 |
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| creator | Sahney, S Abarzua, J Sessums, L |
| description | Four patients with severe theophylline toxicity (theophylline levels of 60 to 180 micrograms/ml) are reported. Three patients with neurotoxicity were treated with hemoperfusion. Two of these were hemoperfused early after the onset of seizures; they recovered with no neurologic deficit. In the third patient hemoperfusion was delayed for 16 hours after uncontrolled seizures; severe brain damage resulted. The fourth patient, who had the highest peak theophylline level but no seizures, was successfully treated with conservative management and peritoneal dialysis. The role of hemoperfusion in severe theophylline intoxication is discussed. |
| doi_str_mv | 10.1542/peds.71.4.615 |
| format | Article |
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Three patients with neurotoxicity were treated with hemoperfusion. Two of these were hemoperfused early after the onset of seizures; they recovered with no neurologic deficit. In the third patient hemoperfusion was delayed for 16 hours after uncontrolled seizures; severe brain damage resulted. The fourth patient, who had the highest peak theophylline level but no seizures, was successfully treated with conservative management and peritoneal dialysis. The role of hemoperfusion in severe theophylline intoxication is discussed.</description><identifier>ISSN: 0031-4005</identifier><identifier>EISSN: 1098-4275</identifier><identifier>DOI: 10.1542/peds.71.4.615</identifier><identifier>PMID: 6835742</identifier><language>eng</language><publisher>United States</publisher><subject>Age Factors ; Central Nervous System Diseases - chemically induced ; Central Nervous System Diseases - therapy ; Child, Preschool ; Female ; Hemoperfusion - methods ; Humans ; Infant ; Peritoneal Dialysis ; Seizures - chemically induced ; Seizures - therapy ; Theophylline - blood ; Theophylline - poisoning</subject><ispartof>Pediatrics (Evanston), 1983-04, Vol.71 (4), p.615-619</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c319t-d9f987232ce701a1205525ff0167d05ed61c78f02e69b110c8fdef32e106adee3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6835742$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sahney, S</creatorcontrib><creatorcontrib>Abarzua, J</creatorcontrib><creatorcontrib>Sessums, L</creatorcontrib><title>Hemoperfusion in theophylline neurotoxicity</title><title>Pediatrics (Evanston)</title><addtitle>Pediatrics</addtitle><description>Four patients with severe theophylline toxicity (theophylline levels of 60 to 180 micrograms/ml) are reported. Three patients with neurotoxicity were treated with hemoperfusion. Two of these were hemoperfused early after the onset of seizures; they recovered with no neurologic deficit. In the third patient hemoperfusion was delayed for 16 hours after uncontrolled seizures; severe brain damage resulted. The fourth patient, who had the highest peak theophylline level but no seizures, was successfully treated with conservative management and peritoneal dialysis. The role of hemoperfusion in severe theophylline intoxication is discussed.</description><subject>Age Factors</subject><subject>Central Nervous System Diseases - chemically induced</subject><subject>Central Nervous System Diseases - therapy</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Hemoperfusion - methods</subject><subject>Humans</subject><subject>Infant</subject><subject>Peritoneal Dialysis</subject><subject>Seizures - chemically induced</subject><subject>Seizures - therapy</subject><subject>Theophylline - blood</subject><subject>Theophylline - poisoning</subject><issn>0031-4005</issn><issn>1098-4275</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo90L9Lw0AYxvFDlFqro6PQyUUS3_d-5JJRRK1QcNH5SC_v0ZMkF-8SsP-9LS1Oz_LhGb6M3SLkqCR_HKhJucZc5gWqMzZHqMpMcq3O2RxAYCYB1CW7SukbAKTSfMZmRSmUlnzOHlbUhYGim5IP_dL3y3FLYdju2tb3tOxpimEMv976cXfNLlzdJro57YJ9vb58Pq-y9cfb-_PTOrMCqzFrKleVmgtuSQPWyEEprpwDLHQDipoCrS4dcCqqDSLY0jXkBCeEom6IxILdH3-HGH4mSqPpfLLUtnVPYUoGRYmao9jD7AhtDClFcmaIvqvjziCYQxxziGM0Gmn2cfb-7nQ8bTpq_vWphvgDOMRgLQ</recordid><startdate>198304</startdate><enddate>198304</enddate><creator>Sahney, S</creator><creator>Abarzua, J</creator><creator>Sessums, L</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>198304</creationdate><title>Hemoperfusion in theophylline neurotoxicity</title><author>Sahney, S ; Abarzua, J ; Sessums, L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-d9f987232ce701a1205525ff0167d05ed61c78f02e69b110c8fdef32e106adee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Age Factors</topic><topic>Central Nervous System Diseases - chemically induced</topic><topic>Central Nervous System Diseases - therapy</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Hemoperfusion - methods</topic><topic>Humans</topic><topic>Infant</topic><topic>Peritoneal Dialysis</topic><topic>Seizures - chemically induced</topic><topic>Seizures - therapy</topic><topic>Theophylline - blood</topic><topic>Theophylline - poisoning</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sahney, S</creatorcontrib><creatorcontrib>Abarzua, J</creatorcontrib><creatorcontrib>Sessums, L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Pediatrics (Evanston)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sahney, S</au><au>Abarzua, J</au><au>Sessums, L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hemoperfusion in theophylline neurotoxicity</atitle><jtitle>Pediatrics (Evanston)</jtitle><addtitle>Pediatrics</addtitle><date>1983-04</date><risdate>1983</risdate><volume>71</volume><issue>4</issue><spage>615</spage><epage>619</epage><pages>615-619</pages><issn>0031-4005</issn><eissn>1098-4275</eissn><abstract>Four patients with severe theophylline toxicity (theophylline levels of 60 to 180 micrograms/ml) are reported. 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| ispartof | Pediatrics (Evanston), 1983-04, Vol.71 (4), p.615-619 |
| issn | 0031-4005 1098-4275 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Age Factors Central Nervous System Diseases - chemically induced Central Nervous System Diseases - therapy Child, Preschool Female Hemoperfusion - methods Humans Infant Peritoneal Dialysis Seizures - chemically induced Seizures - therapy Theophylline - blood Theophylline - poisoning |
| title | Hemoperfusion in theophylline neurotoxicity |
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