Pterostilbene, a bioactive component of blueberries, suppresses the generation of breast cancer stem cells within tumor microenvironment and metastasis via modulating NF-κB/microRNA 448 circuit

Scope Tumor‐associated macrophages (TAMs) have been shown to promote metastasis and malignancy. Pterostilbene, a natural stilbene isolated from blueberries, has been suggested for anti‐cancer effects. Here, we explored the potential cancer stem cells (CSCs)/TAM modulating effects of pterostilbene in...

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Veröffentlicht in:	Molecular nutrition & food research 2013-07, Vol.57 (7), p.1123-1134
Hauptverfasser:	Mak, Ka-Kit, Wu, Alexander T. H., Lee, Wei-Hwa, Chang, Tung-Cheng, Chiou, Jeng-Fong, Wang, Liang-Shun, Wu, Chih-Hsiung, Huang, Chi-Ying F., Shieh, Yi-Shing, Chao, Tsu-Yi, Ho, Chi-Tang, Yen, Gow-Chin, Yeh, Chi-Tai
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta Catenin - genetics beta Catenin - metabolism Biological and medical sciences Blueberry Plants - chemistry Breast cancer stem cells Breast Neoplasms - metabolism Cadherins - genetics Cadherins - metabolism Carcinogenesis - drug effects Carcinogenesis - metabolism Cell Line, Tumor Down-Regulation Epithelial-Mesenchymal Transition Epithelial-to-mesenchymal transition Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Gene Silencing Humans Hyaluronan Receptors - genetics Hyaluronan Receptors - metabolism Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism MCF-7 Cells Medical sciences Mice Mice, SCID MicroRNAs - genetics MicroRNAs - metabolism miR448 Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism NF-kappa B - genetics NF-kappa B - metabolism Nuclear Proteins - genetics Nuclear Proteins - metabolism Pterostilbene Stilbenes - pharmacology Tumor Microenvironment - drug effects Tumor-associated macrophages Tumors Twist-Related Protein 1 - genetics Twist-Related Protein 1 - metabolism Vertebrates: anatomy and physiology, studies on body, several organs or systems Vimentin - genetics Vimentin - metabolism
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