Nitric oxide inhibits CXCL12 expression in neuroinflammation

Chemokine CXCL12 (C‐X‐C motif chemokine ligand 12) restricts immune cell invasion of the central nervous system (CNS) and limits neuroinflammation in experimental autoimmune encephalomyelitis (EAE), an animal model of inflammatory and demyelinating disease of the CNS, multiple sclerosis (MS). Nitric...

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Veröffentlicht in:	Immunology and cell biology 2013-07, Vol.91 (6), p.427-434
Hauptverfasser:	Petković, Filip, Blaževski, Jana, Momčilović, Miljana, Mostarica Stojkovic, Marija, Miljković, Djordje
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals astrocyte Astrocytes - immunology Chemokine CXCL12 - antagonists & inhibitors Chemokine CXCL12 - biosynthesis CXCL12 Disease Models, Animal Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - therapy endothelial cell Endothelial Cells - immunology experimental autoimmune encephalomyelitis Humans Immunotherapy - methods Immunotherapy - trends multiple sclerosis Multiple Sclerosis - immunology Multiple Sclerosis - therapy nitric oxide Nitric Oxide - immunology Nitric Oxide Synthase Type II - genetics Nitric Oxide Synthase Type II - metabolism p38 Mitogen-Activated Protein Kinases - metabolism Rats Rats, Inbred Strains Up-Regulation
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