Tetramethylpyrazine (TMP) protects cerebral neurocytes and inhibits glioma by down regulating chemokine receptor CXCR4 expression
Highlights • TMP effectively inhibits the rise of [Ca2+]i in cerebral neurocytes. • TMP effectively inhibits glutamate releasing in cerebral neurocytes. • TMP significantly decreases the migration and proliferation of C6 glioma cells. • TMP-mediated suppression of C6 gliomas involves inhibition of C...
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| Veröffentlicht in: | Cancer letters 2013-08, Vol.336 (2), p.281-289 |
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| container_issue | 2 |
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| container_title | Cancer letters |
| container_volume | 336 |
| creator | Chen, Zhao Pan, Xueke Georgakilas, Alexandros G Chen, Pei Hu, Huan Yang, Ying Tian, Sijia Xia, Lei Zhang, Jing Cai, Xiaoxiao Ge, Jian Yu, Keming Zhuang, Jing |
| description | Highlights • TMP effectively inhibits the rise of [Ca2+]i in cerebral neurocytes. • TMP effectively inhibits glutamate releasing in cerebral neurocytes. • TMP significantly decreases the migration and proliferation of C6 glioma cells. • TMP-mediated suppression of C6 gliomas involves inhibition of CXCR4 expression. • TMP-mediated neural protection involves inhibition of CXCR4 expression. |
| doi_str_mv | 10.1016/j.canlet.2013.03.015 |
| format | Article |
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All rights reserved.</rights><rights>Copyright Elsevier Limited Aug 19, 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c511t-275ab98ab93faccdbe1b539ec630296712c9fcd67dfdffa99476e578388477573</citedby><cites>FETCH-LOGICAL-c511t-275ab98ab93faccdbe1b539ec630296712c9fcd67dfdffa99476e578388477573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.canlet.2013.03.015$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23523616$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Zhao</creatorcontrib><creatorcontrib>Pan, Xueke</creatorcontrib><creatorcontrib>Georgakilas, Alexandros G</creatorcontrib><creatorcontrib>Chen, Pei</creatorcontrib><creatorcontrib>Hu, Huan</creatorcontrib><creatorcontrib>Yang, Ying</creatorcontrib><creatorcontrib>Tian, Sijia</creatorcontrib><creatorcontrib>Xia, Lei</creatorcontrib><creatorcontrib>Zhang, Jing</creatorcontrib><creatorcontrib>Cai, Xiaoxiao</creatorcontrib><creatorcontrib>Ge, Jian</creatorcontrib><creatorcontrib>Yu, Keming</creatorcontrib><creatorcontrib>Zhuang, Jing</creatorcontrib><title>Tetramethylpyrazine (TMP) protects cerebral neurocytes and inhibits glioma by down regulating chemokine receptor CXCR4 expression</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>Highlights • TMP effectively inhibits the rise of [Ca2+]i in cerebral neurocytes. • TMP effectively inhibits glutamate releasing in cerebral neurocytes. • TMP significantly decreases the migration and proliferation of C6 glioma cells. • TMP-mediated suppression of C6 gliomas involves inhibition of CXCR4 expression. • TMP-mediated neural protection involves inhibition of CXCR4 expression.</description><subject>Alzheimer's disease</subject><subject>Animals</subject><subject>Apoptosis - drug effects</subject><subject>Blood-brain barrier</subject><subject>Brain Neoplasms - drug therapy</subject><subject>Brain Neoplasms - genetics</subject><subject>Brain Neoplasms - metabolism</subject><subject>Brain Neoplasms - prevention & control</subject><subject>C6 glioma cells</subject><subject>Calcium - metabolism</subject><subject>Cancer therapies</subject><subject>Cell adhesion & migration</subject><subject>Cell Line, Tumor</subject><subject>Cell Movement - drug effects</subject><subject>Chemokine CXCL12 - biosynthesis</subject><subject>Chemokines</subject><subject>Chemotherapy</subject><subject>CXCR4</subject><subject>Down-Regulation - drug effects</subject><subject>Free radicals</subject><subject>Glioma - drug therapy</subject><subject>Glioma - metabolism</subject><subject>Glioma - pathology</subject><subject>Glioma - prevention & control</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Hydrogen Peroxide - antagonists & inhibitors</subject><subject>Hydrogen Peroxide - pharmacology</subject><subject>Hypotheses</subject><subject>Hypoxia</subject><subject>Immune system</subject><subject>Ischemia</subject><subject>Lung cancer</subject><subject>Neurons - cytology</subject><subject>Neurons - drug effects</subject><subject>Neurons - metabolism</subject><subject>Neurotoxicity</subject><subject>Pyrazines - pharmacology</subject><subject>Rat cerebral neurocytes</subject><subject>Rats</subject><subject>Receptors, CXCR4 - antagonists & inhibitors</subject><subject>Receptors, CXCR4 - biosynthesis</subject><subject>Receptors, CXCR4 - genetics</subject><subject>Tetramethylpyrazine (TMP)</subject><subject>Tumors</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkl-L1DAUxYMo7rj6DUQCvqwPHZOmadoXQQb_wYqiI_gW0vR2JrNpMpukan3zm5syq8K-CDfk5XdPcs-5CD2mZE0JrZ8f1lo5C2ldEsrWJBfld9CKNqIsRNuQu2hFGKkK1jB-hh7EeCCE8Erw--isZLxkNa1X6NcWUlAjpP1sj3NQP40DfLF9__EZPgafQKeINQTogrLYwRS8nhNErFyPjdubzmRgZ40fFe5m3PvvDgfYTVYl43ZY72H0V4tmAA3H5APefN18qjD8OAaI0Xj3EN0blI3w6OY-R19ev9pu3haXH96827y8LDSnNBWl4Kprm3zYoLTuO6AdZy3ompGyrQUtdTvovhb90A-DattK1MBFw5qmEoILdo4uTrp5rusJYpKjiRqsVQ78FCVlDSWtaAnL6NNb6MFPweXfSVpXPBvd1nWmqhOlg48xwCCPwYwqzJISuUQkD_IUkVwikiQX5bntyY341I3Q_236k0kGXpwAyG58MxBk1Aacht5kE5PsvfnfC7cFtDXOaGWvYIb4bxYZS0nk52VNli2hjJCyYoL9BvlNupE</recordid><startdate>20130819</startdate><enddate>20130819</enddate><creator>Chen, Zhao</creator><creator>Pan, Xueke</creator><creator>Georgakilas, Alexandros G</creator><creator>Chen, Pei</creator><creator>Hu, Huan</creator><creator>Yang, Ying</creator><creator>Tian, Sijia</creator><creator>Xia, Lei</creator><creator>Zhang, Jing</creator><creator>Cai, Xiaoxiao</creator><creator>Ge, Jian</creator><creator>Yu, Keming</creator><creator>Zhuang, Jing</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20130819</creationdate><title>Tetramethylpyrazine (TMP) protects cerebral neurocytes and inhibits glioma by down regulating chemokine receptor CXCR4 expression</title><author>Chen, Zhao ; Pan, Xueke ; Georgakilas, Alexandros G ; Chen, Pei ; Hu, Huan ; Yang, Ying ; Tian, Sijia ; Xia, Lei ; Zhang, Jing ; Cai, Xiaoxiao ; Ge, Jian ; Yu, Keming ; Zhuang, Jing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c511t-275ab98ab93faccdbe1b539ec630296712c9fcd67dfdffa99476e578388477573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Alzheimer's disease</topic><topic>Animals</topic><topic>Apoptosis - 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| identifier | ISSN: 0304-3835 |
| ispartof | Cancer letters, 2013-08, Vol.336 (2), p.281-289 |
| issn | 0304-3835 1872-7980 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Alzheimer's disease Animals Apoptosis - drug effects Blood-brain barrier Brain Neoplasms - drug therapy Brain Neoplasms - genetics Brain Neoplasms - metabolism Brain Neoplasms - prevention & control C6 glioma cells Calcium - metabolism Cancer therapies Cell adhesion & migration Cell Line, Tumor Cell Movement - drug effects Chemokine CXCL12 - biosynthesis Chemokines Chemotherapy CXCR4 Down-Regulation - drug effects Free radicals Glioma - drug therapy Glioma - metabolism Glioma - pathology Glioma - prevention & control Hematology, Oncology and Palliative Medicine Hydrogen Peroxide - antagonists & inhibitors Hydrogen Peroxide - pharmacology Hypotheses Hypoxia Immune system Ischemia Lung cancer Neurons - cytology Neurons - drug effects Neurons - metabolism Neurotoxicity Pyrazines - pharmacology Rat cerebral neurocytes Rats Receptors, CXCR4 - antagonists & inhibitors Receptors, CXCR4 - biosynthesis Receptors, CXCR4 - genetics Tetramethylpyrazine (TMP) Tumors |
| title | Tetramethylpyrazine (TMP) protects cerebral neurocytes and inhibits glioma by down regulating chemokine receptor CXCR4 expression |
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