Tetramethylpyrazine (TMP) protects cerebral neurocytes and inhibits glioma by down regulating chemokine receptor CXCR4 expression

Highlights • TMP effectively inhibits the rise of [Ca2+]i in cerebral neurocytes. • TMP effectively inhibits glutamate releasing in cerebral neurocytes. • TMP significantly decreases the migration and proliferation of C6 glioma cells. • TMP-mediated suppression of C6 gliomas involves inhibition of C...

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Veröffentlicht in:	Cancer letters 2013-08, Vol.336 (2), p.281-289
Hauptverfasser:	Chen, Zhao, Pan, Xueke, Georgakilas, Alexandros G, Chen, Pei, Hu, Huan, Yang, Ying, Tian, Sijia, Xia, Lei, Zhang, Jing, Cai, Xiaoxiao, Ge, Jian, Yu, Keming, Zhuang, Jing
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Animals Apoptosis - drug effects Blood-brain barrier Brain Neoplasms - drug therapy Brain Neoplasms - genetics Brain Neoplasms - metabolism Brain Neoplasms - prevention & control C6 glioma cells Calcium - metabolism Cancer therapies Cell adhesion & migration Cell Line, Tumor Cell Movement - drug effects Chemokine CXCL12 - biosynthesis Chemokines Chemotherapy CXCR4 Down-Regulation - drug effects Free radicals Glioma - drug therapy Glioma - metabolism Glioma - pathology Glioma - prevention & control Hematology, Oncology and Palliative Medicine Hydrogen Peroxide - antagonists & inhibitors Hydrogen Peroxide - pharmacology Hypotheses Hypoxia Immune system Ischemia Lung cancer Neurons - cytology Neurons - drug effects Neurons - metabolism Neurotoxicity Pyrazines - pharmacology Rat cerebral neurocytes Rats Receptors, CXCR4 - antagonists & inhibitors Receptors, CXCR4 - biosynthesis Receptors, CXCR4 - genetics Tetramethylpyrazine (TMP) Tumors
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Beschreibung
Zusammenfassung:	Highlights • TMP effectively inhibits the rise of [Ca2+]i in cerebral neurocytes. • TMP effectively inhibits glutamate releasing in cerebral neurocytes. • TMP significantly decreases the migration and proliferation of C6 glioma cells. • TMP-mediated suppression of C6 gliomas involves inhibition of CXCR4 expression. • TMP-mediated neural protection involves inhibition of CXCR4 expression.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2013.03.015