Caffeine-induced limb malformations: Description of malformations and quantitation of placental transfer
Caffeine was administered intraperitoneally to CD‐1 mice on days 11 and 12 of pregnancy at doses of 80–250 mg/kg. A dose‐related pattern of malformations was seen that included mainly cleft palate, limb malformations, and hematomas. Many of the limb malformations were examined in preparations staine...
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| Veröffentlicht in: | Teratology (Philadelphia) 1983-12, Vol.28 (3), p.427-435 |
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| container_title | Teratology (Philadelphia) |
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| creator | Scott Jr, William J. |
| description | Caffeine was administered intraperitoneally to CD‐1 mice on days 11 and 12 of pregnancy at doses of 80–250 mg/kg. A dose‐related pattern of malformations was seen that included mainly cleft palate, limb malformations, and hematomas. Many of the limb malformations were examined in preparations stained for cartilage and bone and a number of unique structural arrangements were found. As in previous studies, an asymmetric response was seen, the left limbs being affected more often than the right.
Transplacental passage of caffeine was also studied. Caffeine and many metabolites pass into the embryo and attain concentrations slightly below those in maternal plasma. A peak caffeine concentration of 1 mM is attained after a teratogenic dose, which is at least an order of magnitude greater than that of any of the metabolites. |
| doi_str_mv | 10.1002/tera.1420280314 |
| format | Article |
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Transplacental passage of caffeine was also studied. Caffeine and many metabolites pass into the embryo and attain concentrations slightly below those in maternal plasma. A peak caffeine concentration of 1 mM is attained after a teratogenic dose, which is at least an order of magnitude greater than that of any of the metabolites.</description><identifier>ISSN: 0040-3709</identifier><identifier>EISSN: 1096-9926</identifier><identifier>DOI: 10.1002/tera.1420280314</identifier><identifier>PMID: 6665741</identifier><identifier>CODEN: TJADAB</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Abnormalities, Drug-Induced - embryology ; Abnormalities, Drug-Induced - pathology ; Animals ; Biological and medical sciences ; Caffeine - blood ; Caffeine - pharmacology ; Dose-Response Relationship, Drug ; Embryology: invertebrates and vertebrates. Teratology ; Female ; Fundamental and applied biological sciences. Psychology ; Limb Deformities, Congenital ; Maternal-Fetal Exchange ; Mice ; Mice, Inbred Strains ; Pregnancy ; Teratology. Teratogens</subject><ispartof>Teratology (Philadelphia), 1983-12, Vol.28 (3), p.427-435</ispartof><rights>Copyright © 1983 Wiley‐Liss, Inc., A Wiley Company</rights><rights>1984 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5084-c9a87c451d5ebab55aa705445fbc6cbffb81c943f2f945669e8ca7037c498d053</citedby><cites>FETCH-LOGICAL-c5084-c9a87c451d5ebab55aa705445fbc6cbffb81c943f2f945669e8ca7037c498d053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Ftera.1420280314$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Ftera.1420280314$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9610286$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6665741$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Scott Jr, William J.</creatorcontrib><title>Caffeine-induced limb malformations: Description of malformations and quantitation of placental transfer</title><title>Teratology (Philadelphia)</title><addtitle>Teratology</addtitle><description>Caffeine was administered intraperitoneally to CD‐1 mice on days 11 and 12 of pregnancy at doses of 80–250 mg/kg. A dose‐related pattern of malformations was seen that included mainly cleft palate, limb malformations, and hematomas. Many of the limb malformations were examined in preparations stained for cartilage and bone and a number of unique structural arrangements were found. As in previous studies, an asymmetric response was seen, the left limbs being affected more often than the right.
Transplacental passage of caffeine was also studied. Caffeine and many metabolites pass into the embryo and attain concentrations slightly below those in maternal plasma. A peak caffeine concentration of 1 mM is attained after a teratogenic dose, which is at least an order of magnitude greater than that of any of the metabolites.</description><subject>Abnormalities, Drug-Induced - embryology</subject><subject>Abnormalities, Drug-Induced - pathology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Caffeine - blood</subject><subject>Caffeine - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Embryology: invertebrates and vertebrates. Teratology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Limb Deformities, Congenital</subject><subject>Maternal-Fetal Exchange</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Pregnancy</subject><subject>Teratology. Teratogens</subject><issn>0040-3709</issn><issn>1096-9926</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtvFDEQhC0ECpvAmRPSHBC3Sdrjx9hwijYv0AoktChHq8djC8M8NvaMSP59vNplo5w4taz6qrpdhLyjcEoBqrPJRTylvIJKAaP8BVlQ0LLUupIvyQKAQ8lq0K_JcUq_AShQyo7IkZRS1JwuyK8leu_C4MowtLN1bdGFvil67PwYe5zCOKRPxYVLNobN9lWM_rla4NAWdzMOU5jwH7Hp0Lphwq6YIg7Ju_iGvPLYJfd2P0_Iz6vL9fKmXH2__rI8X5VWgOKl1ahqywVthWuwEQKxBsG58I2VtvG-UdRqznzlNRdSaqdsJlj2aNWCYCfk4y53E8e72aXJ9CFZ13U4uHFOhrJagxIsg2c70MYxpei82cTQY3wwFMy2W7Pt1jx1mx3v99Fz07v2wO_LzPqHvY7J5oryz21IB0xLmpNkxj7vsL-hcw__22rWlz_Onx1R7twhTe7-4Mb4x8ia1cLcfrs2t0Kpr2q1NlfsEa0jpHY</recordid><startdate>198312</startdate><enddate>198312</enddate><creator>Scott Jr, William J.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>198312</creationdate><title>Caffeine-induced limb malformations: Description of malformations and quantitation of placental transfer</title><author>Scott Jr, William J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5084-c9a87c451d5ebab55aa705445fbc6cbffb81c943f2f945669e8ca7037c498d053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Abnormalities, Drug-Induced - embryology</topic><topic>Abnormalities, Drug-Induced - pathology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Caffeine - blood</topic><topic>Caffeine - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Embryology: invertebrates and vertebrates. Teratology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Limb Deformities, Congenital</topic><topic>Maternal-Fetal Exchange</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Pregnancy</topic><topic>Teratology. Teratogens</topic><toplevel>online_resources</toplevel><creatorcontrib>Scott Jr, William J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Teratology (Philadelphia)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Scott Jr, William J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Caffeine-induced limb malformations: Description of malformations and quantitation of placental transfer</atitle><jtitle>Teratology (Philadelphia)</jtitle><addtitle>Teratology</addtitle><date>1983-12</date><risdate>1983</risdate><volume>28</volume><issue>3</issue><spage>427</spage><epage>435</epage><pages>427-435</pages><issn>0040-3709</issn><eissn>1096-9926</eissn><coden>TJADAB</coden><abstract>Caffeine was administered intraperitoneally to CD‐1 mice on days 11 and 12 of pregnancy at doses of 80–250 mg/kg. A dose‐related pattern of malformations was seen that included mainly cleft palate, limb malformations, and hematomas. Many of the limb malformations were examined in preparations stained for cartilage and bone and a number of unique structural arrangements were found. As in previous studies, an asymmetric response was seen, the left limbs being affected more often than the right.
Transplacental passage of caffeine was also studied. Caffeine and many metabolites pass into the embryo and attain concentrations slightly below those in maternal plasma. A peak caffeine concentration of 1 mM is attained after a teratogenic dose, which is at least an order of magnitude greater than that of any of the metabolites.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>6665741</pmid><doi>10.1002/tera.1420280314</doi><tpages>9</tpages></addata></record> |
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| ispartof | Teratology (Philadelphia), 1983-12, Vol.28 (3), p.427-435 |
| issn | 0040-3709 1096-9926 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Abnormalities, Drug-Induced - embryology Abnormalities, Drug-Induced - pathology Animals Biological and medical sciences Caffeine - blood Caffeine - pharmacology Dose-Response Relationship, Drug Embryology: invertebrates and vertebrates. Teratology Female Fundamental and applied biological sciences. Psychology Limb Deformities, Congenital Maternal-Fetal Exchange Mice Mice, Inbred Strains Pregnancy Teratology. Teratogens |
| title | Caffeine-induced limb malformations: Description of malformations and quantitation of placental transfer |
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