Differences in Color Vision Impairment Caused by Digoxin, Digitoxin, or Pengitoxin
Color discrimination ability of 53 patients with congestive heart failure and 32 healthy volunteers treated with digoxin, digitoxin, or pengitoxin was determined with the Farnworthʼs Munsell 100 hue test. The patients had been treated with digitalis glycosides for several months prior to color visio...
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| Veröffentlicht in: | Journal of cardiovascular pharmacology 1982-07, Vol.4 (4), p.536-541 |
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| container_title | Journal of cardiovascular pharmacology |
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| creator | Haustein, Knut-Olaf Oltmanns, Gerhard Rietbrock, Norbert Alken, Rudolf G |
| description | Color discrimination ability of 53 patients with congestive heart failure and 32 healthy volunteers treated with digoxin, digitoxin, or pengitoxin was determined with the Farnworthʼs Munsell 100 hue test. The patients had been treated with digitalis glycosides for several months prior to color vision testing. The volunteers received glycosides until a steady-state plasma concentration was reached. Glycoside plasma levels were measured by radioimmunoassay on the 3 days prior to color vision testing. The total error scores, indices of color discrimination, increased with the glycoside plasma levels. Subjects treated with digitoxin or pengitoxin exhibited no marked elevation in total error score at therapeutic concentrations, whereas 17 of 28 subjects with therapeutic digoxin plasma concentrations ( |
| doi_str_mv | 10.1097/00005344-198207000-00003 |
| format | Article |
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The patients had been treated with digitalis glycosides for several months prior to color vision testing. The volunteers received glycosides until a steady-state plasma concentration was reached. Glycoside plasma levels were measured by radioimmunoassay on the 3 days prior to color vision testing. The total error scores, indices of color discrimination, increased with the glycoside plasma levels. Subjects treated with digitoxin or pengitoxin exhibited no marked elevation in total error score at therapeutic concentrations, whereas 17 of 28 subjects with therapeutic digoxin plasma concentrations (<2.0 ng/ml) showed disturbed color discrimination. At toxic plasma levels all 5 digoxin-treated subjects, 7 of 13 digitoxin-treated subjects, and 3 of 8 pengitoxin-treated subjects showed impairment of color discrimination. 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The patients had been treated with digitalis glycosides for several months prior to color vision testing. The volunteers received glycosides until a steady-state plasma concentration was reached. Glycoside plasma levels were measured by radioimmunoassay on the 3 days prior to color vision testing. The total error scores, indices of color discrimination, increased with the glycoside plasma levels. Subjects treated with digitoxin or pengitoxin exhibited no marked elevation in total error score at therapeutic concentrations, whereas 17 of 28 subjects with therapeutic digoxin plasma concentrations (<2.0 ng/ml) showed disturbed color discrimination. At toxic plasma levels all 5 digoxin-treated subjects, 7 of 13 digitoxin-treated subjects, and 3 of 8 pengitoxin-treated subjects showed impairment of color discrimination. The greater tendency of digoxin to impair color vision in comparison with digitoxin and pengitoxin may be related to a higher uptake or different distribution in the retina.</description><subject>Acetyldigoxins - adverse effects</subject><subject>Acetyldigoxins - blood</subject><subject>Adult</subject><subject>Color Perception - drug effects</subject><subject>Digitalis Glycosides - adverse effects</subject><subject>Digitoxin - adverse effects</subject><subject>Digitoxin - blood</subject><subject>Digoxin - adverse effects</subject><subject>Digoxin - blood</subject><subject>Female</subject><subject>Humans</subject><subject>Kinetics</subject><subject>Male</subject><subject>Middle Aged</subject><issn>0160-2446</issn><issn>1533-4023</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UclOwzAQtRColMInIOXEiYDtcezkiFqWSpVACLhaWSbUkKXYiUr_noSE3hiNNNt7M9IbQjxGrxiN1DXtLAAhfBaFnKqu8vsWHJApCwB8QTkckillkvpcCHlMTpz7oJSJQMkJmUgWMuBySp4XJs_RYpWi80zlzeuitt6bcaauvGW5iY0tsWq8edw6zLxk5y3Me_1tqss-Mc2QdpQnrMbylBzlceHwbIwz8np3-zJ_8FeP98v5zcpPBUjw8wgyClEYRRAkAByCAFOhMsnjAFQMKRc8TTvPk4zzjAtJAYEK4IlEFAHMyMWwd2PrrxZdo0vjUiyKuMK6dZqBUipkPTAcgKmtnbOY6401ZWx3mlHdy6n_5NR7OX9b0FHPxxttUmK2J476dXMxzLd10aB1n0W7RavXGBfNWv_3JfgBfyx-KQ</recordid><startdate>198207</startdate><enddate>198207</enddate><creator>Haustein, Knut-Olaf</creator><creator>Oltmanns, Gerhard</creator><creator>Rietbrock, Norbert</creator><creator>Alken, Rudolf G</creator><general>Lippincott-Raven Publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>198207</creationdate><title>Differences in Color Vision Impairment Caused by Digoxin, Digitoxin, or Pengitoxin</title><author>Haustein, Knut-Olaf ; Oltmanns, Gerhard ; Rietbrock, Norbert ; Alken, Rudolf G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4363-f93d03989935b332355ec47d62a537a3c242cc2ccfbd22d24603e30432b6ee453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Acetyldigoxins - adverse effects</topic><topic>Acetyldigoxins - blood</topic><topic>Adult</topic><topic>Color Perception - drug effects</topic><topic>Digitalis Glycosides - adverse effects</topic><topic>Digitoxin - adverse effects</topic><topic>Digitoxin - blood</topic><topic>Digoxin - adverse effects</topic><topic>Digoxin - blood</topic><topic>Female</topic><topic>Humans</topic><topic>Kinetics</topic><topic>Male</topic><topic>Middle Aged</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Haustein, Knut-Olaf</creatorcontrib><creatorcontrib>Oltmanns, Gerhard</creatorcontrib><creatorcontrib>Rietbrock, Norbert</creatorcontrib><creatorcontrib>Alken, Rudolf G</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Journal of cardiovascular pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Haustein, Knut-Olaf</au><au>Oltmanns, Gerhard</au><au>Rietbrock, Norbert</au><au>Alken, Rudolf G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differences in Color Vision Impairment Caused by Digoxin, Digitoxin, or Pengitoxin</atitle><jtitle>Journal of cardiovascular pharmacology</jtitle><addtitle>J Cardiovasc Pharmacol</addtitle><date>1982-07</date><risdate>1982</risdate><volume>4</volume><issue>4</issue><spage>536</spage><epage>541</epage><pages>536-541</pages><issn>0160-2446</issn><eissn>1533-4023</eissn><abstract>Color discrimination ability of 53 patients with congestive heart failure and 32 healthy volunteers treated with digoxin, digitoxin, or pengitoxin was determined with the Farnworthʼs Munsell 100 hue test. The patients had been treated with digitalis glycosides for several months prior to color vision testing. The volunteers received glycosides until a steady-state plasma concentration was reached. Glycoside plasma levels were measured by radioimmunoassay on the 3 days prior to color vision testing. The total error scores, indices of color discrimination, increased with the glycoside plasma levels. Subjects treated with digitoxin or pengitoxin exhibited no marked elevation in total error score at therapeutic concentrations, whereas 17 of 28 subjects with therapeutic digoxin plasma concentrations (<2.0 ng/ml) showed disturbed color discrimination. At toxic plasma levels all 5 digoxin-treated subjects, 7 of 13 digitoxin-treated subjects, and 3 of 8 pengitoxin-treated subjects showed impairment of color discrimination. The greater tendency of digoxin to impair color vision in comparison with digitoxin and pengitoxin may be related to a higher uptake or different distribution in the retina.</abstract><cop>United States</cop><pub>Lippincott-Raven Publishers</pub><pmid>6181326</pmid><doi>10.1097/00005344-198207000-00003</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0160-2446 |
| ispartof | Journal of cardiovascular pharmacology, 1982-07, Vol.4 (4), p.536-541 |
| issn | 0160-2446 1533-4023 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_13777815 |
| source | MEDLINE; Journals@Ovid LWW Legacy Archive; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Acetyldigoxins - adverse effects Acetyldigoxins - blood Adult Color Perception - drug effects Digitalis Glycosides - adverse effects Digitoxin - adverse effects Digitoxin - blood Digoxin - adverse effects Digoxin - blood Female Humans Kinetics Male Middle Aged |
| title | Differences in Color Vision Impairment Caused by Digoxin, Digitoxin, or Pengitoxin |
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