Ethanol and protein metabolism in the liver
The influence of acute and chronic ethanol administration on liver protein synthesis, secretion and degradation has been studied by various research groups. Acute ethanol administration appeared to have few if any effects on protein synthesis in vivo, but reduced the synthetic rates of both stationa...
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| Veröffentlicht in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 1983, Vol.18 (1), p.251-256 |
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| container_title | Pharmacology, biochemistry and behavior |
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| creator | Mørland, J. Bessesen, A. Smith-Kielland, A. Wallin, B. |
| description | The influence of acute and chronic ethanol administration on liver protein synthesis, secretion and degradation has been studied by various research groups. Acute ethanol administration appeared to have few if any effects on protein synthesis
in vivo, but reduced the synthetic rates of both stationary and exported proteins in suspensions of isolated rat liver cells. Chronic ethanol intake for more than 4 weeks inhibited protein synthesis
in vivo, and in cell preparations from treated rats. This inhibitory effect was independent of animal sex, hepatic protein content and diet. The effects of acute and chronic ethanol intake on hepatic protein export are nuclear with both inhibition or no effect being reported. The effect of ethanol on liver protein degradation has only been studied to a limited extent, and the results do not indicate clear and marked effects due to ethanol. The inhibitory effect of chronic ethanol intake on hepatic protein synthesis could be of importance in the development of liver injury. |
| doi_str_mv | 10.1016/0091-3057(83)90181-8 |
| format | Article |
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in vivo, but reduced the synthetic rates of both stationary and exported proteins in suspensions of isolated rat liver cells. Chronic ethanol intake for more than 4 weeks inhibited protein synthesis
in vivo, and in cell preparations from treated rats. This inhibitory effect was independent of animal sex, hepatic protein content and diet. The effects of acute and chronic ethanol intake on hepatic protein export are nuclear with both inhibition or no effect being reported. The effect of ethanol on liver protein degradation has only been studied to a limited extent, and the results do not indicate clear and marked effects due to ethanol. The inhibitory effect of chronic ethanol intake on hepatic protein synthesis could be of importance in the development of liver injury.</description><identifier>ISSN: 0091-3057</identifier><identifier>EISSN: 1873-5177</identifier><identifier>DOI: 10.1016/0091-3057(83)90181-8</identifier><identifier>PMID: 6685297</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Alcoholism - metabolism ; Animals ; Dose-Response Relationship, Drug ; Ethanol - pharmacology ; Ethanol metabolism ; Female ; Humans ; Liver ; Liver - drug effects ; Liver - metabolism ; Male ; Protein synthesis ; Proteins - metabolism ; Rats ; Rats, Inbred Strains</subject><ispartof>Pharmacology, biochemistry and behavior, 1983, Vol.18 (1), p.251-256</ispartof><rights>1983</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-e0af4dd96ddc8e5e04e50bf6a6df0e9ecd771c4b724a2c311267b39357c60f103</citedby><cites>FETCH-LOGICAL-c388t-e0af4dd96ddc8e5e04e50bf6a6df0e9ecd771c4b724a2c311267b39357c60f103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0091-3057(83)90181-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,4021,27921,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6685297$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mørland, J.</creatorcontrib><creatorcontrib>Bessesen, A.</creatorcontrib><creatorcontrib>Smith-Kielland, A.</creatorcontrib><creatorcontrib>Wallin, B.</creatorcontrib><title>Ethanol and protein metabolism in the liver</title><title>Pharmacology, biochemistry and behavior</title><addtitle>Pharmacol Biochem Behav</addtitle><description>The influence of acute and chronic ethanol administration on liver protein synthesis, secretion and degradation has been studied by various research groups. Acute ethanol administration appeared to have few if any effects on protein synthesis
in vivo, but reduced the synthetic rates of both stationary and exported proteins in suspensions of isolated rat liver cells. Chronic ethanol intake for more than 4 weeks inhibited protein synthesis
in vivo, and in cell preparations from treated rats. This inhibitory effect was independent of animal sex, hepatic protein content and diet. The effects of acute and chronic ethanol intake on hepatic protein export are nuclear with both inhibition or no effect being reported. The effect of ethanol on liver protein degradation has only been studied to a limited extent, and the results do not indicate clear and marked effects due to ethanol. The inhibitory effect of chronic ethanol intake on hepatic protein synthesis could be of importance in the development of liver injury.</description><subject>Alcoholism - metabolism</subject><subject>Animals</subject><subject>Dose-Response Relationship, Drug</subject><subject>Ethanol - pharmacology</subject><subject>Ethanol metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Liver</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Protein synthesis</subject><subject>Proteins - metabolism</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMota7-A4U9iSKrk002yV4EKfUDCl70HLLJLI3sR022Bf-9W1t69DQzvO98PYRcUrinQMUDQEkzBoW8Uey2BKpopo7IlCrJsoJKeUymB8spOYvxCwB4LuSETIRQRV7KKbmbD0vT9U1qOpeuQj-g79IWB1P1jY9tOlbDEtPGbzCck5PaNBEv9jEhn8_zj9lrtnh_eZs9LTLLlBoyBFNz50rhnFVYIHAsoKqFEa4GLNE6Kanllcy5yS2jdDypYiUrpBVQU2AJud7NHe_5XmMcdOujxaYxHfbrqCmTklPJRyPfGW3oYwxY61XwrQk_moLeMtJbAHoLQCum_xiNSUKu9vPXVYvu0LSHMuqPOx3HJzceg47WY2fR-YB20K73_y_4BUEDdLk</recordid><startdate>1983</startdate><enddate>1983</enddate><creator>Mørland, J.</creator><creator>Bessesen, A.</creator><creator>Smith-Kielland, A.</creator><creator>Wallin, B.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>1983</creationdate><title>Ethanol and protein metabolism in the liver</title><author>Mørland, J. ; Bessesen, A. ; Smith-Kielland, A. ; Wallin, B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-e0af4dd96ddc8e5e04e50bf6a6df0e9ecd771c4b724a2c311267b39357c60f103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Alcoholism - metabolism</topic><topic>Animals</topic><topic>Dose-Response Relationship, Drug</topic><topic>Ethanol - pharmacology</topic><topic>Ethanol metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Liver</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Protein synthesis</topic><topic>Proteins - metabolism</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mørland, J.</creatorcontrib><creatorcontrib>Bessesen, A.</creatorcontrib><creatorcontrib>Smith-Kielland, A.</creatorcontrib><creatorcontrib>Wallin, B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Pharmacology, biochemistry and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mørland, J.</au><au>Bessesen, A.</au><au>Smith-Kielland, A.</au><au>Wallin, B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ethanol and protein metabolism in the liver</atitle><jtitle>Pharmacology, biochemistry and behavior</jtitle><addtitle>Pharmacol Biochem Behav</addtitle><date>1983</date><risdate>1983</risdate><volume>18</volume><issue>1</issue><spage>251</spage><epage>256</epage><pages>251-256</pages><issn>0091-3057</issn><eissn>1873-5177</eissn><abstract>The influence of acute and chronic ethanol administration on liver protein synthesis, secretion and degradation has been studied by various research groups. Acute ethanol administration appeared to have few if any effects on protein synthesis
in vivo, but reduced the synthetic rates of both stationary and exported proteins in suspensions of isolated rat liver cells. Chronic ethanol intake for more than 4 weeks inhibited protein synthesis
in vivo, and in cell preparations from treated rats. This inhibitory effect was independent of animal sex, hepatic protein content and diet. The effects of acute and chronic ethanol intake on hepatic protein export are nuclear with both inhibition or no effect being reported. The effect of ethanol on liver protein degradation has only been studied to a limited extent, and the results do not indicate clear and marked effects due to ethanol. The inhibitory effect of chronic ethanol intake on hepatic protein synthesis could be of importance in the development of liver injury.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>6685297</pmid><doi>10.1016/0091-3057(83)90181-8</doi><tpages>6</tpages></addata></record> |
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| ispartof | Pharmacology, biochemistry and behavior, 1983, Vol.18 (1), p.251-256 |
| issn | 0091-3057 1873-5177 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Alcoholism - metabolism Animals Dose-Response Relationship, Drug Ethanol - pharmacology Ethanol metabolism Female Humans Liver Liver - drug effects Liver - metabolism Male Protein synthesis Proteins - metabolism Rats Rats, Inbred Strains |
| title | Ethanol and protein metabolism in the liver |
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