Teratologic evaluation of inhaled epichlorohydrin and allyl chloride in rats and rabbits
Pregnant Sprague-Dawley rats and New Zealand white rabbits were exposed to vapors of epichlorohydrin (ECH) at concentrations of 0, 2.5 or 25 ppm or to allyl chloride (AC) at concentrations of 0, 30, or 300 ppm. Exposures were for 7 hr/day on days 6 through 15 (rats) or 6 through 18 (rabbits) of gest...
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| Veröffentlicht in: | Fundamental and applied toxicology 1983-01, Vol.3 (5), p.437-442 |
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| container_title | Fundamental and applied toxicology |
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| creator | John, J.A. Gushow, T.S. Ayres, J.A. Hanley, T.R. Quast, J.F. Rao, K.S. |
| description | Pregnant Sprague-Dawley rats and New Zealand white rabbits were exposed to vapors of epichlorohydrin (ECH) at concentrations of 0, 2.5 or 25 ppm or to allyl chloride (AC) at concentrations of 0, 30, or 300 ppm. Exposures were for 7 hr/day on days 6 through 15 (rats) or 6 through 18 (rabbits) of gestation. Maternal effects including decreased body weight and food consumption were observed among rats inhaling 25 ppm of ECH. No evidence of an adverse effect to the embryo or fetus was observed among rats or rabbits following exposure to ECH. In the AC study maternal toxicity occurred in both rats and rabbits treated at 300 ppm. These consisted of depressed weight gain during gestation and increases in liver weight (both species) and kidney weights (rats only). Fetuses from rats exposed to 300 ppm of AC had a slight delay in skeletal development but there were no other signs of embryotoxicity. Thus, ECH and AC were not teratogenic or embryolethal in rats or rabbits following inhalation exposure to concentrations which induced effects in the maternal animals. |
| doi_str_mv | 10.1016/S0272-0590(83)80018-9 |
| format | Article |
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Exposures were for 7 hr/day on days 6 through 15 (rats) or 6 through 18 (rabbits) of gestation. Maternal effects including decreased body weight and food consumption were observed among rats inhaling 25 ppm of ECH. No evidence of an adverse effect to the embryo or fetus was observed among rats or rabbits following exposure to ECH. In the AC study maternal toxicity occurred in both rats and rabbits treated at 300 ppm. These consisted of depressed weight gain during gestation and increases in liver weight (both species) and kidney weights (rats only). Fetuses from rats exposed to 300 ppm of AC had a slight delay in skeletal development but there were no other signs of embryotoxicity. Thus, ECH and AC were not teratogenic or embryolethal in rats or rabbits following inhalation exposure to concentrations which induced effects in the maternal animals.</description><identifier>ISSN: 0272-0590</identifier><identifier>EISSN: 1095-6832</identifier><identifier>DOI: 10.1016/S0272-0590(83)80018-9</identifier><identifier>PMID: 6642100</identifier><language>eng</language><publisher>United States: Elsevier Science (USA)</publisher><subject>Abnormalities, Drug-Induced ; Allyl Compounds - toxicity ; Animals ; Bone and Bones - abnormalities ; Chlorohydrins - toxicity ; Epichlorohydrin - toxicity ; Female ; Pregnancy ; Rabbits ; Rats ; Rats, Inbred Strains</subject><ispartof>Fundamental and applied toxicology, 1983-01, Vol.3 (5), p.437-442</ispartof><rights>1983 Society of Toxicology</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-fa70adccebcfe6370fcf8b0368f9808b1cfd596a4e66affbfd816fe54c3e6f403</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6642100$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>John, J.A.</creatorcontrib><creatorcontrib>Gushow, T.S.</creatorcontrib><creatorcontrib>Ayres, J.A.</creatorcontrib><creatorcontrib>Hanley, T.R.</creatorcontrib><creatorcontrib>Quast, J.F.</creatorcontrib><creatorcontrib>Rao, K.S.</creatorcontrib><title>Teratologic evaluation of inhaled epichlorohydrin and allyl chloride in rats and rabbits</title><title>Fundamental and applied toxicology</title><addtitle>Fundam Appl Toxicol</addtitle><description>Pregnant Sprague-Dawley rats and New Zealand white rabbits were exposed to vapors of epichlorohydrin (ECH) at concentrations of 0, 2.5 or 25 ppm or to allyl chloride (AC) at concentrations of 0, 30, or 300 ppm. 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Thus, ECH and AC were not teratogenic or embryolethal in rats or rabbits following inhalation exposure to concentrations which induced effects in the maternal animals.</description><subject>Abnormalities, Drug-Induced</subject><subject>Allyl Compounds - toxicity</subject><subject>Animals</subject><subject>Bone and Bones - abnormalities</subject><subject>Chlorohydrins - toxicity</subject><subject>Epichlorohydrin - toxicity</subject><subject>Female</subject><subject>Pregnancy</subject><subject>Rabbits</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><issn>0272-0590</issn><issn>1095-6832</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEQhoMotVZ_QmFPoofVSbObZk8ixS8oeLCCt5BNJjaSbmqyLfTfu_2gV08D8z4zwzyEDCncUaD8_gNG41EOZQU3gt0KACry6oT0KVRlzgUbnZL-ETknFyn9dAwtC-iRHufFiAL0ydcMo2qDD99OZ7hWfqVaF5os2Mw1c-XRZLh0eu5DDPONia7JVGMy5f3GZ7u2M9ihWbcl7aKo6tq16ZKcWeUTXh3qgHw-P80mr_n0_eVt8jjNNatom1s1BmW0xlpb5GwMVltRA-PCVgJETbU1ZcVVgZwra2trBOUWy0Iz5LYANiDX-73LGH5XmFq5cEmj96rBsEqSsnH3f8k7sNyDOoaUIlq5jG6h4kZSkFujcmdUbnVJweTOqKy6ueHhwKpeoDlOHRR2-cM-x-7LtcMok3bYaDQuom6lCe6fC3_J3ogM</recordid><startdate>19830101</startdate><enddate>19830101</enddate><creator>John, J.A.</creator><creator>Gushow, T.S.</creator><creator>Ayres, J.A.</creator><creator>Hanley, T.R.</creator><creator>Quast, J.F.</creator><creator>Rao, K.S.</creator><general>Elsevier Science (USA)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7TV</scope><scope>7U2</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19830101</creationdate><title>Teratologic evaluation of inhaled epichlorohydrin and allyl chloride in rats and rabbits</title><author>John, J.A. ; Gushow, T.S. ; Ayres, J.A. ; Hanley, T.R. ; Quast, J.F. ; Rao, K.S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-fa70adccebcfe6370fcf8b0368f9808b1cfd596a4e66affbfd816fe54c3e6f403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Abnormalities, Drug-Induced</topic><topic>Allyl Compounds - toxicity</topic><topic>Animals</topic><topic>Bone and Bones - abnormalities</topic><topic>Chlorohydrins - toxicity</topic><topic>Epichlorohydrin - toxicity</topic><topic>Female</topic><topic>Pregnancy</topic><topic>Rabbits</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><toplevel>online_resources</toplevel><creatorcontrib>John, J.A.</creatorcontrib><creatorcontrib>Gushow, T.S.</creatorcontrib><creatorcontrib>Ayres, J.A.</creatorcontrib><creatorcontrib>Hanley, T.R.</creatorcontrib><creatorcontrib>Quast, J.F.</creatorcontrib><creatorcontrib>Rao, K.S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Pollution Abstracts</collection><collection>Safety Science and Risk</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Fundamental and applied toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>John, J.A.</au><au>Gushow, T.S.</au><au>Ayres, J.A.</au><au>Hanley, T.R.</au><au>Quast, J.F.</au><au>Rao, K.S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Teratologic evaluation of inhaled epichlorohydrin and allyl chloride in rats and rabbits</atitle><jtitle>Fundamental and applied toxicology</jtitle><addtitle>Fundam Appl Toxicol</addtitle><date>1983-01-01</date><risdate>1983</risdate><volume>3</volume><issue>5</issue><spage>437</spage><epage>442</epage><pages>437-442</pages><issn>0272-0590</issn><eissn>1095-6832</eissn><abstract>Pregnant Sprague-Dawley rats and New Zealand white rabbits were exposed to vapors of epichlorohydrin (ECH) at concentrations of 0, 2.5 or 25 ppm or to allyl chloride (AC) at concentrations of 0, 30, or 300 ppm. Exposures were for 7 hr/day on days 6 through 15 (rats) or 6 through 18 (rabbits) of gestation. Maternal effects including decreased body weight and food consumption were observed among rats inhaling 25 ppm of ECH. No evidence of an adverse effect to the embryo or fetus was observed among rats or rabbits following exposure to ECH. In the AC study maternal toxicity occurred in both rats and rabbits treated at 300 ppm. These consisted of depressed weight gain during gestation and increases in liver weight (both species) and kidney weights (rats only). Fetuses from rats exposed to 300 ppm of AC had a slight delay in skeletal development but there were no other signs of embryotoxicity. Thus, ECH and AC were not teratogenic or embryolethal in rats or rabbits following inhalation exposure to concentrations which induced effects in the maternal animals.</abstract><cop>United States</cop><pub>Elsevier Science (USA)</pub><pmid>6642100</pmid><doi>10.1016/S0272-0590(83)80018-9</doi><tpages>6</tpages></addata></record> |
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| ispartof | Fundamental and applied toxicology, 1983-01, Vol.3 (5), p.437-442 |
| issn | 0272-0590 1095-6832 |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy; Alma/SFX Local Collection |
| subjects | Abnormalities, Drug-Induced Allyl Compounds - toxicity Animals Bone and Bones - abnormalities Chlorohydrins - toxicity Epichlorohydrin - toxicity Female Pregnancy Rabbits Rats Rats, Inbred Strains |
| title | Teratologic evaluation of inhaled epichlorohydrin and allyl chloride in rats and rabbits |
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