Overview of studies on liver carcinogenesis in English sole from Puget Sound; evidence for a xenobiotic chemical etiology I: Pathology and epizootiology
Livers of wild English sole (Parophrys vetulus) from polluted waterways and embayments of Puget Sound, Washington, are affected by a spectrum of multiple, co-occurring idiopathic hepatic lesions, including neoplasms, putative preneoplastic foci of cellular alteration, and unique degeneration conditi...
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Veröffentlicht in: | The Science of the total environment 1990-05, Vol.94 (1), p.33-50 |
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description | Livers of wild English sole (Parophrys vetulus) from polluted waterways and embayments of Puget Sound, Washington, are affected by a spectrum of multiple, co-occurring idiopathic hepatic lesions, including neoplasms, putative preneoplastic foci of cellular alteration, and unique degeneration conditions. Results from a statistical analysis of the patterns of co-occurrence of these lesions in wild English sole indicate that these lesions represent morphologically identifiable steps leading to the development of hepatic neoplasms. This sequence parallels the lesion progression in experimental models of chemically induced liver carcinogenesis in rodents. The hypothesis that these lesions in wild English sole can be caused by exposure to certain xenobiotic hepatotoxic and hepatocarcinogenic compounds in Puget Sound is based on: a) statistical associations between levels of aromatic hydrocarbons (Σ AHs) an sediment and prevalences of these idiopathic liver lesions, b) the contribution of Σ AHs in accounting for the variability in hepatic neoplasm prevalence in a logistic regression model, c) elevated odds ratios for several idiopathic hepatic lesion types in sole from polluted sites in Puget Sound, d) significant correlations between prevalences of idiopathic hepatic lesions and levels of fluorescent metabolites of aromatic compounds (FACs) in bile of English sole, and e) experimental induction of putatively preneoplastic focal lesions in English sole injected with a PAH-enriched fraction of an extract from a contaminated urban sediment from Puget Sound, that were morphologically identical to lesions found in wild English sole from the same site. |
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Results from a statistical analysis of the patterns of co-occurrence of these lesions in wild English sole indicate that these lesions represent morphologically identifiable steps leading to the development of hepatic neoplasms. This sequence parallels the lesion progression in experimental models of chemically induced liver carcinogenesis in rodents. The hypothesis that these lesions in wild English sole can be caused by exposure to certain xenobiotic hepatotoxic and hepatocarcinogenic compounds in Puget Sound is based on: a) statistical associations between levels of aromatic hydrocarbons (Σ AHs) an sediment and prevalences of these idiopathic liver lesions, b) the contribution of Σ AHs in accounting for the variability in hepatic neoplasm prevalence in a logistic regression model, c) elevated odds ratios for several idiopathic hepatic lesion types in sole from polluted sites in Puget Sound, d) significant correlations between prevalences of idiopathic hepatic lesions and levels of fluorescent metabolites of aromatic compounds (FACs) in bile of English sole, and e) experimental induction of putatively preneoplastic focal lesions in English sole injected with a PAH-enriched fraction of an extract from a contaminated urban sediment from Puget Sound, that were morphologically identical to lesions found in wild English sole from the same site.</description><identifier>ISSN: 0048-9697</identifier><identifier>EISSN: 1879-1026</identifier><identifier>DOI: 10.1016/0048-9697(90)90363-Y</identifier><identifier>PMID: 2360038</identifier><identifier>CODEN: STENDL</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Animal, plant and microbial ecology ; Animals ; Applied ecology ; Biological and medical sciences ; Environmental Exposure ; Fish Diseases - chemically induced ; Fish Diseases - classification ; Fish Diseases - pathology ; Flatfishes ; Fundamental and applied biological sciences. 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Results from a statistical analysis of the patterns of co-occurrence of these lesions in wild English sole indicate that these lesions represent morphologically identifiable steps leading to the development of hepatic neoplasms. This sequence parallels the lesion progression in experimental models of chemically induced liver carcinogenesis in rodents. The hypothesis that these lesions in wild English sole can be caused by exposure to certain xenobiotic hepatotoxic and hepatocarcinogenic compounds in Puget Sound is based on: a) statistical associations between levels of aromatic hydrocarbons (Σ AHs) an sediment and prevalences of these idiopathic liver lesions, b) the contribution of Σ AHs in accounting for the variability in hepatic neoplasm prevalence in a logistic regression model, c) elevated odds ratios for several idiopathic hepatic lesion types in sole from polluted sites in Puget Sound, d) significant correlations between prevalences of idiopathic hepatic lesions and levels of fluorescent metabolites of aromatic compounds (FACs) in bile of English sole, and e) experimental induction of putatively preneoplastic focal lesions in English sole injected with a PAH-enriched fraction of an extract from a contaminated urban sediment from Puget Sound, that were morphologically identical to lesions found in wild English sole from the same site.</description><subject>Animal, plant and microbial ecology</subject><subject>Animals</subject><subject>Applied ecology</subject><subject>Biological and medical sciences</subject><subject>Environmental Exposure</subject><subject>Fish Diseases - chemically induced</subject><subject>Fish Diseases - classification</subject><subject>Fish Diseases - pathology</subject><subject>Flatfishes</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Liver Neoplasms - chemically induced</subject><subject>Liver Neoplasms - classification</subject><subject>Liver Neoplasms - pathology</subject><subject>Liver Neoplasms - veterinary</subject><subject>Washington</subject><subject>Water Pollution, Chemical</subject><subject>Xenobiotics</subject><issn>0048-9697</issn><issn>1879-1026</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc-KFDEQxoMo67j6Bgo5iKyH1qTTfxIFYVlWXVjYBfWwp5BJKjMl3cmYdI-uT-LjmnGGOZpLkXy_qhTfR8hzzt5wxru3jDWyUp3qzxR7rZjoRHX3gCy47FXFWd09JIsj8pg8yfk7K6eX_ISc1KJjTMgF-XOzhbRF-Emjp3maHUKmMdAByzu1JlkMcQUBMmaKgV6G1YB5TXMcgPoUR3o7r2CiX-Ic3HsKW3QQbJFioob-ghCXGCe01K5hRGsGChPGIa7u6dU7emum9f5igqOwwd8xHuSn5JE3Q4Znh3pKvn28_Hrxubq--XR1cX5dWSHqqQIuRaN6pjwTS9VK2TLZNl6IxjVdXxsnpG-FNbWEhnsGzBkvGTTLtqmV5yBOyav93E2KP2bIkx4xWxgGEyDOWXPRt-UPWcBmD9oUc07g9SbhaNK95kzvAtE7t_XOba2Y_heIvittLw7z5-UI7th0SKDoLw-6ycUen0ywmI9Y2wrZ1rxgH_YYFC9KXklnizunHSawk3YR_7_HX3jrqW4</recordid><startdate>19900501</startdate><enddate>19900501</enddate><creator>Myers, M.S.</creator><creator>Landahl, J.T.</creator><creator>Krahn, M.M.</creator><creator>Johnson, L.L.</creator><creator>McCain, B.B.</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QH</scope></search><sort><creationdate>19900501</creationdate><title>Overview of studies on liver carcinogenesis in English sole from Puget Sound; evidence for a xenobiotic chemical etiology I: Pathology and epizootiology</title><author>Myers, M.S. ; Landahl, J.T. ; Krahn, M.M. ; Johnson, L.L. ; McCain, B.B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-e18349709f03b958850854f334d4672ad38f53ca28e41f0e0daf80e4b5429f1e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Animal, plant and microbial ecology</topic><topic>Animals</topic><topic>Applied ecology</topic><topic>Biological and medical sciences</topic><topic>Environmental Exposure</topic><topic>Fish Diseases - chemically induced</topic><topic>Fish Diseases - classification</topic><topic>Fish Diseases - pathology</topic><topic>Flatfishes</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Liver Neoplasms - chemically induced</topic><topic>Liver Neoplasms - classification</topic><topic>Liver Neoplasms - pathology</topic><topic>Liver Neoplasms - veterinary</topic><topic>Washington</topic><topic>Water Pollution, Chemical</topic><topic>Xenobiotics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Myers, M.S.</creatorcontrib><creatorcontrib>Landahl, J.T.</creatorcontrib><creatorcontrib>Krahn, M.M.</creatorcontrib><creatorcontrib>Johnson, L.L.</creatorcontrib><creatorcontrib>McCain, B.B.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aqualine</collection><jtitle>The Science of the total environment</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Myers, M.S.</au><au>Landahl, J.T.</au><au>Krahn, M.M.</au><au>Johnson, L.L.</au><au>McCain, B.B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Overview of studies on liver carcinogenesis in English sole from Puget Sound; evidence for a xenobiotic chemical etiology I: Pathology and epizootiology</atitle><jtitle>The Science of the total environment</jtitle><addtitle>Sci Total Environ</addtitle><date>1990-05-01</date><risdate>1990</risdate><volume>94</volume><issue>1</issue><spage>33</spage><epage>50</epage><pages>33-50</pages><issn>0048-9697</issn><eissn>1879-1026</eissn><coden>STENDL</coden><abstract>Livers of wild English sole (Parophrys vetulus) from polluted waterways and embayments of Puget Sound, Washington, are affected by a spectrum of multiple, co-occurring idiopathic hepatic lesions, including neoplasms, putative preneoplastic foci of cellular alteration, and unique degeneration conditions. Results from a statistical analysis of the patterns of co-occurrence of these lesions in wild English sole indicate that these lesions represent morphologically identifiable steps leading to the development of hepatic neoplasms. This sequence parallels the lesion progression in experimental models of chemically induced liver carcinogenesis in rodents. The hypothesis that these lesions in wild English sole can be caused by exposure to certain xenobiotic hepatotoxic and hepatocarcinogenic compounds in Puget Sound is based on: a) statistical associations between levels of aromatic hydrocarbons (Σ AHs) an sediment and prevalences of these idiopathic liver lesions, b) the contribution of Σ AHs in accounting for the variability in hepatic neoplasm prevalence in a logistic regression model, c) elevated odds ratios for several idiopathic hepatic lesion types in sole from polluted sites in Puget Sound, d) significant correlations between prevalences of idiopathic hepatic lesions and levels of fluorescent metabolites of aromatic compounds (FACs) in bile of English sole, and e) experimental induction of putatively preneoplastic focal lesions in English sole injected with a PAH-enriched fraction of an extract from a contaminated urban sediment from Puget Sound, that were morphologically identical to lesions found in wild English sole from the same site.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>2360038</pmid><doi>10.1016/0048-9697(90)90363-Y</doi><tpages>18</tpages></addata></record> |
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subjects | Animal, plant and microbial ecology Animals Applied ecology Biological and medical sciences Environmental Exposure Fish Diseases - chemically induced Fish Diseases - classification Fish Diseases - pathology Flatfishes Fundamental and applied biological sciences. Psychology Liver Neoplasms - chemically induced Liver Neoplasms - classification Liver Neoplasms - pathology Liver Neoplasms - veterinary Washington Water Pollution, Chemical Xenobiotics |
title | Overview of studies on liver carcinogenesis in English sole from Puget Sound; evidence for a xenobiotic chemical etiology I: Pathology and epizootiology |
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