Carbon tetrachloride and bromotrichloromethane toxicity: Dual role of covalent binding of metabolic cleavage products and lipid peroxidation in depression of microsomal calcium sequestration

We have investigated the importance of covalent binding and lipid peroxidation on the depression of microsomal calcium sequestration associated with in vitro metabolism of 14CCl 4. Studies with CBrCl 3 are also reported. In aerobic systems, promethazine was used to block lipid peroxidation, measured...

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Veröffentlicht in:	Biochemical pharmacology 1983-01, Vol.32 (10), p.1613-1617
Hauptverfasser:	Waller, Robert L., Glende, Erica, Recknagel, Richard O.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bromotrichloromethane - pharmacology Calcium - metabolism Carbon Tetrachloride - pharmacology Chloroform - analogs & derivatives Depression, Chemical Lipid Metabolism Lipid Peroxides - biosynthesis Male Malondialdehyde - metabolism Microsomes, Liver - drug effects Microsomes, Liver - metabolism Promethazine - pharmacology Rats Rats, Inbred Strains
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