Carbon tetrachloride and bromotrichloromethane toxicity: Dual role of covalent binding of metabolic cleavage products and lipid peroxidation in depression of microsomal calcium sequestration
We have investigated the importance of covalent binding and lipid peroxidation on the depression of microsomal calcium sequestration associated with in vitro metabolism of 14CCl 4. Studies with CBrCl 3 are also reported. In aerobic systems, promethazine was used to block lipid peroxidation, measured...
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| Veröffentlicht in: | Biochemical pharmacology 1983-01, Vol.32 (10), p.1613-1617 |
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| container_title | Biochemical pharmacology |
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| creator | Waller, Robert L. Glende, Erica Recknagel, Richard O. |
| description | We have investigated the importance of covalent binding and lipid peroxidation on the depression of microsomal calcium sequestration associated with
in vitro metabolism of
14CCl
4. Studies with CBrCl
3 are also reported. In aerobic systems, promethazine was used to block lipid peroxidation, measured as malondialdehyde (MDA) generation. Effects of low levels of lipid peroxidation were tested in Fe
2+ -supplemented systems free of halogenated hydrocarbons. The results indicate that microsomal calcium sequestration can be depressed significantly by metabolism of either CCl
4 or CBrCl
3 in the absence of MDA generation, or by lipid peroxidation occurring in the absence of halogenated hydrocarbons. |
| doi_str_mv | 10.1016/0006-2952(83)90336-2 |
| format | Article |
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in vitro metabolism of
14CCl
4. Studies with CBrCl
3 are also reported. In aerobic systems, promethazine was used to block lipid peroxidation, measured as malondialdehyde (MDA) generation. Effects of low levels of lipid peroxidation were tested in Fe
2+ -supplemented systems free of halogenated hydrocarbons. The results indicate that microsomal calcium sequestration can be depressed significantly by metabolism of either CCl
4 or CBrCl
3 in the absence of MDA generation, or by lipid peroxidation occurring in the absence of halogenated hydrocarbons.</description><identifier>ISSN: 0006-2952</identifier><identifier>EISSN: 1873-2968</identifier><identifier>DOI: 10.1016/0006-2952(83)90336-2</identifier><identifier>PMID: 6860348</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Animals ; Bromotrichloromethane - pharmacology ; Calcium - metabolism ; Carbon Tetrachloride - pharmacology ; Chloroform - analogs & derivatives ; Depression, Chemical ; Lipid Metabolism ; Lipid Peroxides - biosynthesis ; Male ; Malondialdehyde - metabolism ; Microsomes, Liver - drug effects ; Microsomes, Liver - metabolism ; Promethazine - pharmacology ; Rats ; Rats, Inbred Strains</subject><ispartof>Biochemical pharmacology, 1983-01, Vol.32 (10), p.1613-1617</ispartof><rights>1983</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-2952(83)90336-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6860348$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Waller, Robert L.</creatorcontrib><creatorcontrib>Glende, Erica</creatorcontrib><creatorcontrib>Recknagel, Richard O.</creatorcontrib><title>Carbon tetrachloride and bromotrichloromethane toxicity: Dual role of covalent binding of metabolic cleavage products and lipid peroxidation in depression of microsomal calcium sequestration</title><title>Biochemical pharmacology</title><addtitle>Biochem Pharmacol</addtitle><description>We have investigated the importance of covalent binding and lipid peroxidation on the depression of microsomal calcium sequestration associated with
in vitro metabolism of
14CCl
4. Studies with CBrCl
3 are also reported. In aerobic systems, promethazine was used to block lipid peroxidation, measured as malondialdehyde (MDA) generation. Effects of low levels of lipid peroxidation were tested in Fe
2+ -supplemented systems free of halogenated hydrocarbons. The results indicate that microsomal calcium sequestration can be depressed significantly by metabolism of either CCl
4 or CBrCl
3 in the absence of MDA generation, or by lipid peroxidation occurring in the absence of halogenated hydrocarbons.</description><subject>Animals</subject><subject>Bromotrichloromethane - pharmacology</subject><subject>Calcium - metabolism</subject><subject>Carbon Tetrachloride - pharmacology</subject><subject>Chloroform - analogs & derivatives</subject><subject>Depression, Chemical</subject><subject>Lipid Metabolism</subject><subject>Lipid Peroxides - biosynthesis</subject><subject>Male</subject><subject>Malondialdehyde - metabolism</subject><subject>Microsomes, Liver - drug effects</subject><subject>Microsomes, Liver - metabolism</subject><subject>Promethazine - pharmacology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><issn>0006-2952</issn><issn>1873-2968</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUsmO1DAQtRBoaAb-ACSfEBwa7DiLw2Ek1KzSSFzgbFXsykwhJw6202J-jm_D6Wlx5VSqqlfv1cbYcyneSCHbt0KIdl_1TfVKq9e9UKp4D9hO6k6VcKsfst0_yGP2JKWfm6tbecEuihGq1jv25wBxCDPPmCPYWx8iOeQwOz7EMIUc6RQME-ZbmJHn8Jss5bt3_MMKnsfgkYeR23AEj3PmA82O5pstVkpgCJ4stx7hCDfIlxjcanM6CXhayPEFY6F0kKl0QTN3uERMafM2DrIxpDAVKQve0jrxhL9WTKXbreIpezSCT_jsbC_Zj08fvx--7K-_ff56eH-9R1WpvIe-rlDAKOuxbzvRdaqHftS1hlFBrXStpFJV48AOjbSibofGCdXXWvZDrQWqS_bynrdMcJI3EyWL3pedhDUZqbpGbCT_B7ZatKItwBdn4DpM6MwSaYJ4Z86XKfmr-zyWsY6E0SRLOFt0FNFm4wIZKcz2CWa7q9nObLQyp08wlfoLO0Gppg</recordid><startdate>19830101</startdate><enddate>19830101</enddate><creator>Waller, Robert L.</creator><creator>Glende, Erica</creator><creator>Recknagel, Richard O.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7U7</scope><scope>C1K</scope><scope>7QP</scope></search><sort><creationdate>19830101</creationdate><title>Carbon tetrachloride and bromotrichloromethane toxicity: Dual role of covalent binding of metabolic cleavage products and lipid peroxidation in depression of microsomal calcium sequestration</title><author>Waller, Robert L. ; Glende, Erica ; Recknagel, Richard O.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e323t-a942e0af14f96707739a9f848af3a4384313325dacb51c046b5d0394819b480e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Animals</topic><topic>Bromotrichloromethane - pharmacology</topic><topic>Calcium - metabolism</topic><topic>Carbon Tetrachloride - pharmacology</topic><topic>Chloroform - analogs & derivatives</topic><topic>Depression, Chemical</topic><topic>Lipid Metabolism</topic><topic>Lipid Peroxides - biosynthesis</topic><topic>Male</topic><topic>Malondialdehyde - metabolism</topic><topic>Microsomes, Liver - drug effects</topic><topic>Microsomes, Liver - metabolism</topic><topic>Promethazine - pharmacology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Waller, Robert L.</creatorcontrib><creatorcontrib>Glende, Erica</creatorcontrib><creatorcontrib>Recknagel, Richard O.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Calcium & Calcified Tissue Abstracts</collection><jtitle>Biochemical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Waller, Robert L.</au><au>Glende, Erica</au><au>Recknagel, Richard O.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Carbon tetrachloride and bromotrichloromethane toxicity: Dual role of covalent binding of metabolic cleavage products and lipid peroxidation in depression of microsomal calcium sequestration</atitle><jtitle>Biochemical pharmacology</jtitle><addtitle>Biochem Pharmacol</addtitle><date>1983-01-01</date><risdate>1983</risdate><volume>32</volume><issue>10</issue><spage>1613</spage><epage>1617</epage><pages>1613-1617</pages><issn>0006-2952</issn><eissn>1873-2968</eissn><abstract>We have investigated the importance of covalent binding and lipid peroxidation on the depression of microsomal calcium sequestration associated with
in vitro metabolism of
14CCl
4. Studies with CBrCl
3 are also reported. In aerobic systems, promethazine was used to block lipid peroxidation, measured as malondialdehyde (MDA) generation. Effects of low levels of lipid peroxidation were tested in Fe
2+ -supplemented systems free of halogenated hydrocarbons. The results indicate that microsomal calcium sequestration can be depressed significantly by metabolism of either CCl
4 or CBrCl
3 in the absence of MDA generation, or by lipid peroxidation occurring in the absence of halogenated hydrocarbons.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>6860348</pmid><doi>10.1016/0006-2952(83)90336-2</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-2952 |
| ispartof | Biochemical pharmacology, 1983-01, Vol.32 (10), p.1613-1617 |
| issn | 0006-2952 1873-2968 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_13750313 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Bromotrichloromethane - pharmacology Calcium - metabolism Carbon Tetrachloride - pharmacology Chloroform - analogs & derivatives Depression, Chemical Lipid Metabolism Lipid Peroxides - biosynthesis Male Malondialdehyde - metabolism Microsomes, Liver - drug effects Microsomes, Liver - metabolism Promethazine - pharmacology Rats Rats, Inbred Strains |
| title | Carbon tetrachloride and bromotrichloromethane toxicity: Dual role of covalent binding of metabolic cleavage products and lipid peroxidation in depression of microsomal calcium sequestration |
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