Oxythioquinox-induced hepatomegaly

Oxythioquinox, administered in solution in the dietary lipids at 400 mg/kg fresh food for 21 days, caused liver hypertrophy with severe steatosis. The levels of liver triglycerides increased 40-fold, phospholipids 2-fold and cholesterol 7-fold respectively. The steatosis was thought to be due to the...

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Veröffentlicht in:	Toxicology letters 1983-01, Vol.19 (1), p.159-164
Hauptverfasser:	Carrera, G., Cambon-Gros, C., Mitjavila, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Fatty Liver - chemically induced Fungicides, Industrial - toxicity Hepatomegaly - chemically induced Lipid Metabolism Male Medical sciences Pesticides, fertilizers and other agrochemicals toxicology Quinoxalines - toxicity Rats Rats, Inbred Strains Toxicology Vitamins - pharmacology
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Zusammenfassung:	Oxythioquinox, administered in solution in the dietary lipids at 400 mg/kg fresh food for 21 days, caused liver hypertrophy with severe steatosis. The levels of liver triglycerides increased 40-fold, phospholipids 2-fold and cholesterol 7-fold respectively. The steatosis was thought to be due to the effect of oxythioquinox on cell energy metabolism. The results demonstrate the variation of oxythioquinox toxicity with its degree of solubilisation in the vehicle of administration.
ISSN:	0378-4274 1879-3169
DOI:	10.1016/0378-4274(83)90277-1