Natural killer cells in systemic lupus erythematosus. Abnormal numbers and functional immaturity of HNK-1 super(+) cells

Natural killer cells in systemic lupus erythematosus. Abnormal numbers and functional immaturity of HNK-1 super(+) cells

A monoclonal antibody, HNK-1, that detects a differentiation antigen on human granular lymphocytes with natural killer (NK) activity was used to enumerate this subpopulation in the peripheral blood of 14 patients with systemic lupus erythematosus (SLE). The evidence suggests that levels of HNK-1 sup...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Arthritis and rheumatism 1983-01, Vol.26 (5), p.623-629
Hauptverfasser: Egan, M L, Mendelsohn, S L, Abo, T, Balch, C M
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 629
container_issue 5
container_start_page 623
container_title Arthritis and rheumatism
container_volume 26
creator Egan, M L
Mendelsohn, S L
Abo, T
Balch, C M
description A monoclonal antibody, HNK-1, that detects a differentiation antigen on human granular lymphocytes with natural killer (NK) activity was used to enumerate this subpopulation in the peripheral blood of 14 patients with systemic lupus erythematosus (SLE). The evidence suggests that levels of HNK-1 super(+) lymphocytes are abnormal and functionally immature in most SLE patients. Longitudinal studies conducted over several months on a number of SLE patients demonstrated fluctuations in the ratio of mature and immature HNK-1 super(+) cells and total HNK-1 super(+) cells. Additional patients tested over longer periods of time will have to be studied to determine whether the proportion of mature NK cells (HNK-1 super(+) OKT3 super(-)) and immature NK cells (HNK-1 super(+) OKT3 super(+)) will be useful in predicting the clinical course of disease.
format Article
fullrecord <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_miscellaneous_13748666</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>13748666</sourcerecordid><originalsourceid>FETCH-proquest_miscellaneous_137486663</originalsourceid><addsrcrecordid>eNqNjU9rwkAUxPegULX9Du8kFokk3Rj1WMQSEDz1Lpv0hW7dP3HfPjDf3oT6ATwNM_xmZiQmaZrmiVzvshcxJfrr7Ydcy4m4nVTkoAxctDEYoEZjCLQD6iii1TUYbpkAQxd_0aroiWkFn5XzwfY1x7bCQKDcDzTs6qi962Nt7bCrYwe-gfJ0TDIgbjEslu__H69i3ChD-PbQmZh_Hb73ZdIGf2WkeLaaBlI59EznTG7ybVEU8mnwDg8JUEo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>13748666</pqid></control><display><type>article</type><title>Natural killer cells in systemic lupus erythematosus. Abnormal numbers and functional immaturity of HNK-1 super(+) cells</title><source>Access via Wiley Online Library</source><source>Alma/SFX Local Collection</source><creator>Egan, M L ; Mendelsohn, S L ; Abo, T ; Balch, C M</creator><creatorcontrib>Egan, M L ; Mendelsohn, S L ; Abo, T ; Balch, C M</creatorcontrib><description>A monoclonal antibody, HNK-1, that detects a differentiation antigen on human granular lymphocytes with natural killer (NK) activity was used to enumerate this subpopulation in the peripheral blood of 14 patients with systemic lupus erythematosus (SLE). The evidence suggests that levels of HNK-1 super(+) lymphocytes are abnormal and functionally immature in most SLE patients. Longitudinal studies conducted over several months on a number of SLE patients demonstrated fluctuations in the ratio of mature and immature HNK-1 super(+) cells and total HNK-1 super(+) cells. Additional patients tested over longer periods of time will have to be studied to determine whether the proportion of mature NK cells (HNK-1 super(+) OKT3 super(-)) and immature NK cells (HNK-1 super(+) OKT3 super(+)) will be useful in predicting the clinical course of disease.</description><identifier>ISSN: 0004-3591</identifier><language>eng</language><ispartof>Arthritis and rheumatism, 1983-01, Vol.26 (5), p.623-629</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>Egan, M L</creatorcontrib><creatorcontrib>Mendelsohn, S L</creatorcontrib><creatorcontrib>Abo, T</creatorcontrib><creatorcontrib>Balch, C M</creatorcontrib><title>Natural killer cells in systemic lupus erythematosus. Abnormal numbers and functional immaturity of HNK-1 super(+) cells</title><title>Arthritis and rheumatism</title><description>A monoclonal antibody, HNK-1, that detects a differentiation antigen on human granular lymphocytes with natural killer (NK) activity was used to enumerate this subpopulation in the peripheral blood of 14 patients with systemic lupus erythematosus (SLE). The evidence suggests that levels of HNK-1 super(+) lymphocytes are abnormal and functionally immature in most SLE patients. Longitudinal studies conducted over several months on a number of SLE patients demonstrated fluctuations in the ratio of mature and immature HNK-1 super(+) cells and total HNK-1 super(+) cells. Additional patients tested over longer periods of time will have to be studied to determine whether the proportion of mature NK cells (HNK-1 super(+) OKT3 super(-)) and immature NK cells (HNK-1 super(+) OKT3 super(+)) will be useful in predicting the clinical course of disease.</description><issn>0004-3591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><recordid>eNqNjU9rwkAUxPegULX9Du8kFokk3Rj1WMQSEDz1Lpv0hW7dP3HfPjDf3oT6ATwNM_xmZiQmaZrmiVzvshcxJfrr7Ydcy4m4nVTkoAxctDEYoEZjCLQD6iii1TUYbpkAQxd_0aroiWkFn5XzwfY1x7bCQKDcDzTs6qi962Nt7bCrYwe-gfJ0TDIgbjEslu__H69i3ChD-PbQmZh_Hb73ZdIGf2WkeLaaBlI59EznTG7ybVEU8mnwDg8JUEo</recordid><startdate>19830101</startdate><enddate>19830101</enddate><creator>Egan, M L</creator><creator>Mendelsohn, S L</creator><creator>Abo, T</creator><creator>Balch, C M</creator><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>19830101</creationdate><title>Natural killer cells in systemic lupus erythematosus. Abnormal numbers and functional immaturity of HNK-1 super(+) cells</title><author>Egan, M L ; Mendelsohn, S L ; Abo, T ; Balch, C M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_miscellaneous_137486663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><toplevel>online_resources</toplevel><creatorcontrib>Egan, M L</creatorcontrib><creatorcontrib>Mendelsohn, S L</creatorcontrib><creatorcontrib>Abo, T</creatorcontrib><creatorcontrib>Balch, C M</creatorcontrib><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Arthritis and rheumatism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Egan, M L</au><au>Mendelsohn, S L</au><au>Abo, T</au><au>Balch, C M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Natural killer cells in systemic lupus erythematosus. Abnormal numbers and functional immaturity of HNK-1 super(+) cells</atitle><jtitle>Arthritis and rheumatism</jtitle><date>1983-01-01</date><risdate>1983</risdate><volume>26</volume><issue>5</issue><spage>623</spage><epage>629</epage><pages>623-629</pages><issn>0004-3591</issn><abstract>A monoclonal antibody, HNK-1, that detects a differentiation antigen on human granular lymphocytes with natural killer (NK) activity was used to enumerate this subpopulation in the peripheral blood of 14 patients with systemic lupus erythematosus (SLE). The evidence suggests that levels of HNK-1 super(+) lymphocytes are abnormal and functionally immature in most SLE patients. Longitudinal studies conducted over several months on a number of SLE patients demonstrated fluctuations in the ratio of mature and immature HNK-1 super(+) cells and total HNK-1 super(+) cells. Additional patients tested over longer periods of time will have to be studied to determine whether the proportion of mature NK cells (HNK-1 super(+) OKT3 super(-)) and immature NK cells (HNK-1 super(+) OKT3 super(+)) will be useful in predicting the clinical course of disease.</abstract></addata></record>
fulltext fulltext
identifier ISSN: 0004-3591
ispartof Arthritis and rheumatism, 1983-01, Vol.26 (5), p.623-629
issn 0004-3591
language eng
recordid cdi_proquest_miscellaneous_13748666
source Access via Wiley Online Library; Alma/SFX Local Collection
title Natural killer cells in systemic lupus erythematosus. Abnormal numbers and functional immaturity of HNK-1 super(+) cells
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T18%3A57%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Natural%20killer%20cells%20in%20systemic%20lupus%20erythematosus.%20Abnormal%20numbers%20and%20functional%20immaturity%20of%20HNK-1%20super(+)%20cells&rft.jtitle=Arthritis%20and%20rheumatism&rft.au=Egan,%20M%20L&rft.date=1983-01-01&rft.volume=26&rft.issue=5&rft.spage=623&rft.epage=629&rft.pages=623-629&rft.issn=0004-3591&rft_id=info:doi/&rft_dat=%3Cproquest%3E13748666%3C/proquest%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=13748666&rft_id=info:pmid/&rfr_iscdi=true