Humoral Hypercalcemia Caused by a Rat Leydig-Cell Tumor is Associated with Suppressed Parathyroid Hormone Secretion and Increased Urinary cAMP Excretion
Summary We studied the effect of a transplantable Leydig-cell tumor (Rice H-500) on serum calcium, parathyroid hormone (PTH), and urinary cAMP in intact Fischer-344 rats. The tumor caused rapid and severe hypercalcemia (control = 10.5±0.1 mg/dl) [mean ± S.E.] vs. 14.6±0.9 at day 12 post tumor inocul...
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| Veröffentlicht in: | Hormone and metabolic research 1983-06, Vol.15 (6), p.299-304 |
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| container_title | Hormone and metabolic research |
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| creator | Spiegel, A. M. Saxe, A. W. Deftos, L. J. Brennan, M. F. |
| description | Summary
We studied the effect of a transplantable Leydig-cell tumor (Rice H-500) on serum calcium, parathyroid hormone (PTH), and urinary cAMP in intact Fischer-344 rats. The tumor caused rapid and severe hypercalcemia (control = 10.5±0.1 mg/dl) [mean ± S.E.] vs. 14.6±0.9 at day 12 post tumor inoculation) without evidence of metastasis. Progressive renal impairment and death generally occurred within 15 days of tumor inoculation. Serum PTH declined from control values before hypercalcemia occurred and was significantly reduced in tumorbearing hypercalcemic rats (mean = 60±8% of control values). Urinary cAMP excretion was increased in tumor-bearing rats (mean at day 12 post inoculation = 12.2±1.4 nmol/dl creatinine clearance vs. control = 6.2±0.2) and correlated positively with serum calcium. The Rice H-500 Leydig-cell tumor appears to secrete a humoral factor capable of causing hypercalcemia. This factor may also increase urinary cAMP excretion in a manner analogous to PTH, but it is not detected by PTH radioimmunoassay. |
| doi_str_mv | 10.1055/s-2007-1018700 |
| format | Article |
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We studied the effect of a transplantable Leydig-cell tumor (Rice H-500) on serum calcium, parathyroid hormone (PTH), and urinary cAMP in intact Fischer-344 rats. The tumor caused rapid and severe hypercalcemia (control = 10.5±0.1 mg/dl) [mean ± S.E.] vs. 14.6±0.9 at day 12 post tumor inoculation) without evidence of metastasis. Progressive renal impairment and death generally occurred within 15 days of tumor inoculation. Serum PTH declined from control values before hypercalcemia occurred and was significantly reduced in tumorbearing hypercalcemic rats (mean = 60±8% of control values). Urinary cAMP excretion was increased in tumor-bearing rats (mean at day 12 post inoculation = 12.2±1.4 nmol/dl creatinine clearance vs. control = 6.2±0.2) and correlated positively with serum calcium. The Rice H-500 Leydig-cell tumor appears to secrete a humoral factor capable of causing hypercalcemia. This factor may also increase urinary cAMP excretion in a manner analogous to PTH, but it is not detected by PTH radioimmunoassay.</description><identifier>ISSN: 0018-5043</identifier><identifier>EISSN: 1439-4286</identifier><identifier>DOI: 10.1055/s-2007-1018700</identifier><identifier>PMID: 6307850</identifier><language>eng</language><publisher>Germany</publisher><subject>Animals ; Cyclic AMP - urine ; Hypercalcemia - etiology ; Hypercalcemia - metabolism ; Leydig Cell Tumor - complications ; Leydig Cell Tumor - metabolism ; Male ; Parathyroid Hormone - blood ; Rats ; Rats, Inbred F344 ; Vitamin D - toxicity</subject><ispartof>Hormone and metabolic research, 1983-06, Vol.15 (6), p.299-304</ispartof><rights>Georg Thieme Verlag, Stuttgart · New York</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-3cca7ad3b505b7c7ef13ec814c0561e0ddcc16433d55ec0616389b623bb0c4f33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2007-1018700.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><link.rule.ids>314,780,784,3017,3018,27924,27925,54559</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6307850$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Spiegel, A. M.</creatorcontrib><creatorcontrib>Saxe, A. W.</creatorcontrib><creatorcontrib>Deftos, L. J.</creatorcontrib><creatorcontrib>Brennan, M. F.</creatorcontrib><title>Humoral Hypercalcemia Caused by a Rat Leydig-Cell Tumor is Associated with Suppressed Parathyroid Hormone Secretion and Increased Urinary cAMP Excretion</title><title>Hormone and metabolic research</title><addtitle>Horm Metab Res</addtitle><description>Summary
We studied the effect of a transplantable Leydig-cell tumor (Rice H-500) on serum calcium, parathyroid hormone (PTH), and urinary cAMP in intact Fischer-344 rats. The tumor caused rapid and severe hypercalcemia (control = 10.5±0.1 mg/dl) [mean ± S.E.] vs. 14.6±0.9 at day 12 post tumor inoculation) without evidence of metastasis. Progressive renal impairment and death generally occurred within 15 days of tumor inoculation. Serum PTH declined from control values before hypercalcemia occurred and was significantly reduced in tumorbearing hypercalcemic rats (mean = 60±8% of control values). Urinary cAMP excretion was increased in tumor-bearing rats (mean at day 12 post inoculation = 12.2±1.4 nmol/dl creatinine clearance vs. control = 6.2±0.2) and correlated positively with serum calcium. The Rice H-500 Leydig-cell tumor appears to secrete a humoral factor capable of causing hypercalcemia. This factor may also increase urinary cAMP excretion in a manner analogous to PTH, but it is not detected by PTH radioimmunoassay.</description><subject>Animals</subject><subject>Cyclic AMP - urine</subject><subject>Hypercalcemia - etiology</subject><subject>Hypercalcemia - metabolism</subject><subject>Leydig Cell Tumor - complications</subject><subject>Leydig Cell Tumor - metabolism</subject><subject>Male</subject><subject>Parathyroid Hormone - blood</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Vitamin D - toxicity</subject><issn>0018-5043</issn><issn>1439-4286</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU9v1DAQxS1EVZbClRuST9xc7LWdZI-rVelWWkTVP2fLGc-yrpI42IlovgkfF0cbceNkjef3nmbmEfJJ8GvBtf6a2JrzkgkuqpLzN2QllNwwta6Kt2TF8y_TXMl35H1KL7lUG6EuyWUheVlpviJ_9mMbom3ofuoxgm0AW2_pzo4JHa0naumDHegBJ-d_sh02DX2aFdQnuk0pgLdDBn_74UQfx76PmGbhvY12OE0xeEf3IbahQ_qIEHHwoaO2c_Suy5Wd2efoOxsnCtvv9_TmdYE-kIujbRJ-XN4r8vzt5mm3Z4cft3e77YGB1JuBSQBbWidrzXVdQolHIREqoYDrQiB3DkAUSkqnNQIvRCGrTV2sZV1zUEcpr8iXs28fw68R02BanyDvaTsMYzJClkqJSmfw-gxCDClFPJo--jYPbgQ3cxQmmTkKs0SRBZ8X57Fu0f3Dl9vnPjv3h5PHFs1LGGOXV_2f31_U-JQh</recordid><startdate>198306</startdate><enddate>198306</enddate><creator>Spiegel, A. M.</creator><creator>Saxe, A. W.</creator><creator>Deftos, L. J.</creator><creator>Brennan, M. F.</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope></search><sort><creationdate>198306</creationdate><title>Humoral Hypercalcemia Caused by a Rat Leydig-Cell Tumor is Associated with Suppressed Parathyroid Hormone Secretion and Increased Urinary cAMP Excretion</title><author>Spiegel, A. M. ; Saxe, A. W. ; Deftos, L. J. ; Brennan, M. F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-3cca7ad3b505b7c7ef13ec814c0561e0ddcc16433d55ec0616389b623bb0c4f33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Animals</topic><topic>Cyclic AMP - urine</topic><topic>Hypercalcemia - etiology</topic><topic>Hypercalcemia - metabolism</topic><topic>Leydig Cell Tumor - complications</topic><topic>Leydig Cell Tumor - metabolism</topic><topic>Male</topic><topic>Parathyroid Hormone - blood</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>Vitamin D - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Spiegel, A. M.</creatorcontrib><creatorcontrib>Saxe, A. W.</creatorcontrib><creatorcontrib>Deftos, L. J.</creatorcontrib><creatorcontrib>Brennan, M. F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><jtitle>Hormone and metabolic research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Spiegel, A. M.</au><au>Saxe, A. W.</au><au>Deftos, L. J.</au><au>Brennan, M. F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Humoral Hypercalcemia Caused by a Rat Leydig-Cell Tumor is Associated with Suppressed Parathyroid Hormone Secretion and Increased Urinary cAMP Excretion</atitle><jtitle>Hormone and metabolic research</jtitle><addtitle>Horm Metab Res</addtitle><date>1983-06</date><risdate>1983</risdate><volume>15</volume><issue>6</issue><spage>299</spage><epage>304</epage><pages>299-304</pages><issn>0018-5043</issn><eissn>1439-4286</eissn><abstract>Summary
We studied the effect of a transplantable Leydig-cell tumor (Rice H-500) on serum calcium, parathyroid hormone (PTH), and urinary cAMP in intact Fischer-344 rats. The tumor caused rapid and severe hypercalcemia (control = 10.5±0.1 mg/dl) [mean ± S.E.] vs. 14.6±0.9 at day 12 post tumor inoculation) without evidence of metastasis. Progressive renal impairment and death generally occurred within 15 days of tumor inoculation. Serum PTH declined from control values before hypercalcemia occurred and was significantly reduced in tumorbearing hypercalcemic rats (mean = 60±8% of control values). Urinary cAMP excretion was increased in tumor-bearing rats (mean at day 12 post inoculation = 12.2±1.4 nmol/dl creatinine clearance vs. control = 6.2±0.2) and correlated positively with serum calcium. The Rice H-500 Leydig-cell tumor appears to secrete a humoral factor capable of causing hypercalcemia. This factor may also increase urinary cAMP excretion in a manner analogous to PTH, but it is not detected by PTH radioimmunoassay.</abstract><cop>Germany</cop><pmid>6307850</pmid><doi>10.1055/s-2007-1018700</doi><tpages>6</tpages></addata></record> |
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| ispartof | Hormone and metabolic research, 1983-06, Vol.15 (6), p.299-304 |
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| language | eng |
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| source | MEDLINE; Thieme Connect Journals |
| subjects | Animals Cyclic AMP - urine Hypercalcemia - etiology Hypercalcemia - metabolism Leydig Cell Tumor - complications Leydig Cell Tumor - metabolism Male Parathyroid Hormone - blood Rats Rats, Inbred F344 Vitamin D - toxicity |
| title | Humoral Hypercalcemia Caused by a Rat Leydig-Cell Tumor is Associated with Suppressed Parathyroid Hormone Secretion and Increased Urinary cAMP Excretion |
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