Cell growth state determines susceptibility of repair DNA synthesis to inhibition by hydroxyurea and 1-β-D-arabinofuranosylcytosine

The effects of inhibitors of replicative DNA synthesis on repair DNA synthesis have been examined by autoradiography in several different cell types and in cells in different growth states. Hydroxyurea (HU) and 1-β-D-arabino-furanosylcytosine (ara C), administered together, influence unscheduled DNA...

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Veröffentlicht in:	Carcinogenesis (N.Y.); (United States) 1983-08, Vol.4 (8), p.1039-1043
Hauptverfasser:	Mullinger, Ann M., Collins, Andrew R.S., Johnson, Robert T.
Format:	Artikel
Sprache:	eng
Schlagworte:	550201 - Biochemistry- Tracer Techniques 560301 - Chemicals Metabolism & Toxicology- Cells- (-1987) AMIDES ANIMAL CELLS Animals Antineoplastic agents AUTORADIOGRAPHY BASIC BIOLOGICAL SCIENCES Biological and medical sciences BIOLOGICAL EFFECTS BIOLOGICAL RECOVERY BIOLOGICAL REPAIR CELL CULTURES CELL CYCLE Cell Cycle - drug effects Cell Cycle - radiation effects Cell Line Cell Transformation, Neoplastic Chemotherapy CHO CELLS CONNECTIVE TISSUE CELLS Cricetinae Cricetulus Cytarabine - pharmacology DNA DNA Repair - drug effects DNA REPLICATION DNA Replication - drug effects Drug Interactions ELECTROMAGNETIC RADIATION FIBROBLASTS Fibroblasts - drug effects Fibroblasts - physiology HELA CELLS HeLa Cells - drug effects HYDROXY COMPOUNDS HYDROXYUREA Hydroxyurea - pharmacology Kinetics Medical sciences NUCLEIC ACID REPLICATION NUCLEIC ACIDS ORGANIC COMPOUNDS ORGANIC NITROGEN COMPOUNDS Pharmacology. Drug treatments RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIATIONS RECOVERY REPAIR SOMATIC CELLS ULTRAVIOLET RADIATION Ultraviolet Rays
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