An essential role of PI(4,5)P2 for maintaining the activity of the transient receptor potential canonical (TRPC)4β

The transient receptor potential canonical 4 (TRPC4) channel is a Ca 2+ -permeable nonselective cation channel in mammalian cells and mediates a number of cellular functions. Many studies show that TRPC channels are activated by stimulation of Gα q -phospholipase C (PLC)-coupled receptors. However,...

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Veröffentlicht in:	Pflügers Archiv 2013-07, Vol.465 (7), p.1011-1021
Hauptverfasser:	Kim, Hana, Jeon, Jae-Pyo, Hong, Chansik, Kim, Jinsung, Myeong, Jongyoun, Jeon, Ju-Hong, So, Insuk
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Animals Biomedical and Life Sciences Biomedicine Cell Biology GTP-Binding Protein alpha Subunits, Gq-G11 - genetics GTP-Binding Protein alpha Subunits, Gq-G11 - metabolism HEK293 Cells Human Physiology Humans Ion Channels Mice Molecular Medicine Mutation Neurosciences Phosphatidylinositol 4,5-Diphosphate - metabolism Phosphotransferases (Alcohol Group Acceptor) - metabolism Receptors Receptors and Transporters TRPC Cation Channels - metabolism
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