Bone quality, as measured by trabecular bone score, in patients with primary hyperparathyroidism
ObjectiveIn primary hyperparathyroidism (PHPT), vertebral fractures (VFx) occur regardless of bone mineral density (BMD) and may depend on decreased bone quality. Trabecular bone score (TBS) is a texture measurement acquired during a spinal dual-energy X-ray absorptiometry (DXA). Recently, TBS has b...
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| Veröffentlicht in: | European journal of endocrinology 2013-08, Vol.169 (2), p.155-162 |
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| creator | Eller-Vainicher, Cristina Filopanti, Marcello Palmieri, Serena Ulivieri, Fabio Massimo Morelli, Valentina Zhukouskaya, Volha V Cairoli, Elisa Pino, Rosa Naccarato, Antonella Verga, Uberta Scillitani, Alfredo Beck-Peccoz, Paolo Chiodini, Iacopo |
| description | ObjectiveIn primary hyperparathyroidism (PHPT), vertebral fractures (VFx) occur regardless of bone mineral density (BMD) and may depend on decreased bone quality. Trabecular bone score (TBS) is a texture measurement acquired during a spinal dual-energy X-ray absorptiometry (DXA). Recently, TBS has been proposed as an index of bone micro-architecture.DesignWe studied 92 PHPT patients (74 females, age 62.1±9.7 years) and 98 control subjects. In all patients at baseline, in 20 surgically treated patients and in 10 conservatively treated patients after 24 months, TBS, spinal (lumbar spine (LS)) and femoral (total hip (TH) and femoral neck (FN)) BMD were assessed by DXA and VFx by spinal radiograph.ResultsPHPT patients had lower TBS (−2.39±1.8) and higher VFx prevalence (43.5%) than controls (−0.98±1.07 and 8.2% respectively, both P |
| doi_str_mv | 10.1530/EJE-13-0305 |
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Trabecular bone score (TBS) is a texture measurement acquired during a spinal dual-energy X-ray absorptiometry (DXA). Recently, TBS has been proposed as an index of bone micro-architecture.DesignWe studied 92 PHPT patients (74 females, age 62.1±9.7 years) and 98 control subjects. In all patients at baseline, in 20 surgically treated patients and in 10 conservatively treated patients after 24 months, TBS, spinal (lumbar spine (LS)) and femoral (total hip (TH) and femoral neck (FN)) BMD were assessed by DXA and VFx by spinal radiograph.ResultsPHPT patients had lower TBS (−2.39±1.8) and higher VFx prevalence (43.5%) than controls (−0.98±1.07 and 8.2% respectively, both P<0.0001). TBS was associated with VFx (odds ratio 1.4, 95% CI 1.1–1.9, P=0.02), regardless of LS-BMD, age, BMI and gender, and showed a better compromise between sensitivity (75%) and specificity (61.5%) for detecting VFx than LS-BMD, TH-BMD and FN-BMD (31 and 75%, 72 and 44.2%, and 64 and 65% respectively). In surgically treated patients, TBS, LS-BMD, TH-BMD and FN-BMD increased (+47±44.8,+29.2±34.1,+49.4±48.7 and +30.2±39.3% respectively, all P<0.0001). Among patients treated conservatively, TBS decreased significantly in those (n=3) with incident VFx (−1.3±0.3) compared with those without (−0.01±0.9, P=0.048), while BMD changes were not statistically different (LS 0.3±1.2 vs −0.8±0.9 respectively, P=0.19; TH 0.4±0.8 vs −0.8±1.4 respectively, P=0.13 and FN 0.4±0.9 vs −0.8±1.4 respectively, P=0.14).ConclusionsIn PHPT, bone quality, as measured by TBS, is reduced and associated with VFx and improves after surgery.</description><identifier>ISSN: 0804-4643</identifier><identifier>EISSN: 1479-683X</identifier><identifier>DOI: 10.1530/EJE-13-0305</identifier><identifier>PMID: 23682095</identifier><language>eng</language><publisher>England: BioScientifica</publisher><subject>Absorptiometry, Photon ; Aged ; Bone Density ; Clinical Study ; Cross-Sectional Studies ; Female ; Femur Neck - diagnostic imaging ; Femur Neck - pathology ; Hip Joint - diagnostic imaging ; Hip Joint - pathology ; Humans ; Hyperparathyroidism, Primary - blood ; Hyperparathyroidism, Primary - diagnostic imaging ; Hyperparathyroidism, Primary - pathology ; Longitudinal Studies ; Lumbar Vertebrae - diagnostic imaging ; Lumbar Vertebrae - pathology ; Male ; Middle Aged ; Odds Ratio ; Postmenopause ; Prospective Studies ; Sensitivity and Specificity ; Spinal Fractures - blood ; Spinal Fractures - diagnostic imaging ; Spinal Fractures - pathology</subject><ispartof>European journal of endocrinology, 2013-08, Vol.169 (2), p.155-162</ispartof><rights>2013 European Society of Endocrinology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b368t-aa1229ccde9235484f6de7dd8ce3816ff81889803fdc635f5132e30be8728f963</citedby><cites>FETCH-LOGICAL-b368t-aa1229ccde9235484f6de7dd8ce3816ff81889803fdc635f5132e30be8728f963</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23682095$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eller-Vainicher, Cristina</creatorcontrib><creatorcontrib>Filopanti, Marcello</creatorcontrib><creatorcontrib>Palmieri, Serena</creatorcontrib><creatorcontrib>Ulivieri, Fabio Massimo</creatorcontrib><creatorcontrib>Morelli, Valentina</creatorcontrib><creatorcontrib>Zhukouskaya, Volha V</creatorcontrib><creatorcontrib>Cairoli, Elisa</creatorcontrib><creatorcontrib>Pino, Rosa</creatorcontrib><creatorcontrib>Naccarato, Antonella</creatorcontrib><creatorcontrib>Verga, Uberta</creatorcontrib><creatorcontrib>Scillitani, Alfredo</creatorcontrib><creatorcontrib>Beck-Peccoz, Paolo</creatorcontrib><creatorcontrib>Chiodini, Iacopo</creatorcontrib><title>Bone quality, as measured by trabecular bone score, in patients with primary hyperparathyroidism</title><title>European journal of endocrinology</title><addtitle>Eur J Endocrinol</addtitle><description>ObjectiveIn primary hyperparathyroidism (PHPT), vertebral fractures (VFx) occur regardless of bone mineral density (BMD) and may depend on decreased bone quality. Trabecular bone score (TBS) is a texture measurement acquired during a spinal dual-energy X-ray absorptiometry (DXA). Recently, TBS has been proposed as an index of bone micro-architecture.DesignWe studied 92 PHPT patients (74 females, age 62.1±9.7 years) and 98 control subjects. In all patients at baseline, in 20 surgically treated patients and in 10 conservatively treated patients after 24 months, TBS, spinal (lumbar spine (LS)) and femoral (total hip (TH) and femoral neck (FN)) BMD were assessed by DXA and VFx by spinal radiograph.ResultsPHPT patients had lower TBS (−2.39±1.8) and higher VFx prevalence (43.5%) than controls (−0.98±1.07 and 8.2% respectively, both P<0.0001). TBS was associated with VFx (odds ratio 1.4, 95% CI 1.1–1.9, P=0.02), regardless of LS-BMD, age, BMI and gender, and showed a better compromise between sensitivity (75%) and specificity (61.5%) for detecting VFx than LS-BMD, TH-BMD and FN-BMD (31 and 75%, 72 and 44.2%, and 64 and 65% respectively). In surgically treated patients, TBS, LS-BMD, TH-BMD and FN-BMD increased (+47±44.8,+29.2±34.1,+49.4±48.7 and +30.2±39.3% respectively, all P<0.0001). Among patients treated conservatively, TBS decreased significantly in those (n=3) with incident VFx (−1.3±0.3) compared with those without (−0.01±0.9, P=0.048), while BMD changes were not statistically different (LS 0.3±1.2 vs −0.8±0.9 respectively, P=0.19; TH 0.4±0.8 vs −0.8±1.4 respectively, P=0.13 and FN 0.4±0.9 vs −0.8±1.4 respectively, P=0.14).ConclusionsIn PHPT, bone quality, as measured by TBS, is reduced and associated with VFx and improves after surgery.</description><subject>Absorptiometry, Photon</subject><subject>Aged</subject><subject>Bone Density</subject><subject>Clinical Study</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Femur Neck - diagnostic imaging</subject><subject>Femur Neck - pathology</subject><subject>Hip Joint - diagnostic imaging</subject><subject>Hip Joint - pathology</subject><subject>Humans</subject><subject>Hyperparathyroidism, Primary - blood</subject><subject>Hyperparathyroidism, Primary - diagnostic imaging</subject><subject>Hyperparathyroidism, Primary - pathology</subject><subject>Longitudinal Studies</subject><subject>Lumbar Vertebrae - diagnostic imaging</subject><subject>Lumbar Vertebrae - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Odds Ratio</subject><subject>Postmenopause</subject><subject>Prospective Studies</subject><subject>Sensitivity and Specificity</subject><subject>Spinal Fractures - blood</subject><subject>Spinal Fractures - diagnostic imaging</subject><subject>Spinal Fractures - pathology</subject><issn>0804-4643</issn><issn>1479-683X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PwzAURS0EoqUwsSOPSDRgx4njjFCVL1ViAYktOPazapQ0qe0I5d-T0MLI9N5w7tXVQeickmuaMnKzfF5GlEWEkfQATWmS5REX7P0QTYkgSZTwhE3QifefhNDhJ8doEjMuYpKnU_Rx12wAbztZ2dDPsfS4Buk7BxqXPQ5OlqC6SjpcjpxXjYM5thvcymBhEzz-smGNW2dr6Xq87ltwrXQyrHvXWG19fYqOjKw8nO3vDL3dL18Xj9Hq5eFpcbuKymFLiKSkcZwrpSGPWZqIxHANmdZCAROUGyOoELkgzGjFWWpSymJgpASRxcLknM3Q5a63dc22Ax-K2noFVSU30HS-oCxjCeP8B73aoco13jswxX5_QUkxKi0GpUOgGJUO9MW-uCtr0H_sr8MBoDugtI1XoxVrrJL_ln4DfKeCTA</recordid><startdate>201308</startdate><enddate>201308</enddate><creator>Eller-Vainicher, Cristina</creator><creator>Filopanti, Marcello</creator><creator>Palmieri, Serena</creator><creator>Ulivieri, Fabio Massimo</creator><creator>Morelli, Valentina</creator><creator>Zhukouskaya, Volha V</creator><creator>Cairoli, Elisa</creator><creator>Pino, Rosa</creator><creator>Naccarato, Antonella</creator><creator>Verga, Uberta</creator><creator>Scillitani, Alfredo</creator><creator>Beck-Peccoz, Paolo</creator><creator>Chiodini, Iacopo</creator><general>BioScientifica</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201308</creationdate><title>Bone quality, as measured by trabecular bone score, in patients with primary hyperparathyroidism</title><author>Eller-Vainicher, Cristina ; Filopanti, Marcello ; Palmieri, Serena ; Ulivieri, Fabio Massimo ; Morelli, Valentina ; Zhukouskaya, Volha V ; Cairoli, Elisa ; Pino, Rosa ; Naccarato, Antonella ; Verga, Uberta ; Scillitani, Alfredo ; Beck-Peccoz, Paolo ; Chiodini, Iacopo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b368t-aa1229ccde9235484f6de7dd8ce3816ff81889803fdc635f5132e30be8728f963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Absorptiometry, Photon</topic><topic>Aged</topic><topic>Bone Density</topic><topic>Clinical Study</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Femur Neck - diagnostic imaging</topic><topic>Femur Neck - pathology</topic><topic>Hip Joint - diagnostic imaging</topic><topic>Hip Joint - pathology</topic><topic>Humans</topic><topic>Hyperparathyroidism, Primary - blood</topic><topic>Hyperparathyroidism, Primary - diagnostic imaging</topic><topic>Hyperparathyroidism, Primary - pathology</topic><topic>Longitudinal Studies</topic><topic>Lumbar Vertebrae - diagnostic imaging</topic><topic>Lumbar Vertebrae - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Odds Ratio</topic><topic>Postmenopause</topic><topic>Prospective Studies</topic><topic>Sensitivity and Specificity</topic><topic>Spinal Fractures - blood</topic><topic>Spinal Fractures - diagnostic imaging</topic><topic>Spinal Fractures - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eller-Vainicher, Cristina</creatorcontrib><creatorcontrib>Filopanti, Marcello</creatorcontrib><creatorcontrib>Palmieri, Serena</creatorcontrib><creatorcontrib>Ulivieri, Fabio Massimo</creatorcontrib><creatorcontrib>Morelli, Valentina</creatorcontrib><creatorcontrib>Zhukouskaya, Volha V</creatorcontrib><creatorcontrib>Cairoli, Elisa</creatorcontrib><creatorcontrib>Pino, Rosa</creatorcontrib><creatorcontrib>Naccarato, Antonella</creatorcontrib><creatorcontrib>Verga, Uberta</creatorcontrib><creatorcontrib>Scillitani, Alfredo</creatorcontrib><creatorcontrib>Beck-Peccoz, Paolo</creatorcontrib><creatorcontrib>Chiodini, Iacopo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eller-Vainicher, Cristina</au><au>Filopanti, Marcello</au><au>Palmieri, Serena</au><au>Ulivieri, Fabio Massimo</au><au>Morelli, Valentina</au><au>Zhukouskaya, Volha V</au><au>Cairoli, Elisa</au><au>Pino, Rosa</au><au>Naccarato, Antonella</au><au>Verga, Uberta</au><au>Scillitani, Alfredo</au><au>Beck-Peccoz, Paolo</au><au>Chiodini, Iacopo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bone quality, as measured by trabecular bone score, in patients with primary hyperparathyroidism</atitle><jtitle>European journal of endocrinology</jtitle><addtitle>Eur J Endocrinol</addtitle><date>2013-08</date><risdate>2013</risdate><volume>169</volume><issue>2</issue><spage>155</spage><epage>162</epage><pages>155-162</pages><issn>0804-4643</issn><eissn>1479-683X</eissn><abstract>ObjectiveIn primary hyperparathyroidism (PHPT), vertebral fractures (VFx) occur regardless of bone mineral density (BMD) and may depend on decreased bone quality. Trabecular bone score (TBS) is a texture measurement acquired during a spinal dual-energy X-ray absorptiometry (DXA). Recently, TBS has been proposed as an index of bone micro-architecture.DesignWe studied 92 PHPT patients (74 females, age 62.1±9.7 years) and 98 control subjects. In all patients at baseline, in 20 surgically treated patients and in 10 conservatively treated patients after 24 months, TBS, spinal (lumbar spine (LS)) and femoral (total hip (TH) and femoral neck (FN)) BMD were assessed by DXA and VFx by spinal radiograph.ResultsPHPT patients had lower TBS (−2.39±1.8) and higher VFx prevalence (43.5%) than controls (−0.98±1.07 and 8.2% respectively, both P<0.0001). TBS was associated with VFx (odds ratio 1.4, 95% CI 1.1–1.9, P=0.02), regardless of LS-BMD, age, BMI and gender, and showed a better compromise between sensitivity (75%) and specificity (61.5%) for detecting VFx than LS-BMD, TH-BMD and FN-BMD (31 and 75%, 72 and 44.2%, and 64 and 65% respectively). In surgically treated patients, TBS, LS-BMD, TH-BMD and FN-BMD increased (+47±44.8,+29.2±34.1,+49.4±48.7 and +30.2±39.3% respectively, all P<0.0001). Among patients treated conservatively, TBS decreased significantly in those (n=3) with incident VFx (−1.3±0.3) compared with those without (−0.01±0.9, P=0.048), while BMD changes were not statistically different (LS 0.3±1.2 vs −0.8±0.9 respectively, P=0.19; TH 0.4±0.8 vs −0.8±1.4 respectively, P=0.13 and FN 0.4±0.9 vs −0.8±1.4 respectively, P=0.14).ConclusionsIn PHPT, bone quality, as measured by TBS, is reduced and associated with VFx and improves after surgery.</abstract><cop>England</cop><pub>BioScientifica</pub><pmid>23682095</pmid><doi>10.1530/EJE-13-0305</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Absorptiometry, Photon Aged Bone Density Clinical Study Cross-Sectional Studies Female Femur Neck - diagnostic imaging Femur Neck - pathology Hip Joint - diagnostic imaging Hip Joint - pathology Humans Hyperparathyroidism, Primary - blood Hyperparathyroidism, Primary - diagnostic imaging Hyperparathyroidism, Primary - pathology Longitudinal Studies Lumbar Vertebrae - diagnostic imaging Lumbar Vertebrae - pathology Male Middle Aged Odds Ratio Postmenopause Prospective Studies Sensitivity and Specificity Spinal Fractures - blood Spinal Fractures - diagnostic imaging Spinal Fractures - pathology |
| title | Bone quality, as measured by trabecular bone score, in patients with primary hyperparathyroidism |
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