The effects of stenting on shear stress: relevance to endothelial injury and repair

Stent deployment following balloon angioplasty is used routinely to treat coronary artery disease. These interventions cause damage and loss of endothelial cells (EC), and thus promote in-stent thrombosis and restenosis. Injured arteries are repaired (intrinsically) by locally derived EC and by circ...

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Veröffentlicht in:	Cardiovascular research 2013-07, Vol.99 (2), p.269-275
Hauptverfasser:	Van der Heiden, Kim, Gijsen, Frank J H, Narracott, Andrew, Hsiao, Sarah, Halliday, Ian, Gunn, Julian, Wentzel, Jolanda J, Evans, Paul C
Format:	Artikel
Sprache:	eng
Schlagworte:	Angioplasty, Balloon - adverse effects Angioplasty, Balloon - instrumentation Animals Biomechanical Phenomena Cell Movement Cell Proliferation Computer Simulation Constriction, Pathologic Endothelium, Vascular - injuries Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Endothelium, Vascular - physiopathology Hemodynamics Humans Mechanotransduction, Cellular Models, Cardiovascular Regeneration Regional Blood Flow Stents Stress, Mechanical Thrombosis - etiology Thrombosis - pathology Thrombosis - physiopathology Vascular System Injuries - etiology Vascular System Injuries - metabolism Vascular System Injuries - pathology Vascular System Injuries - physiopathology
Online-Zugang:	Volltext
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