Identification of 1-hydroxypyrene as a major metabolite of pyrene in pig urine

1. 1-Hydroxypyrene is a major metabolite of pyrene given orally to pigs. 2. A method for isolating the metabolite from urine is described, utilizing C18-adsorbent cartridges, h.p.l.c. separation, and fluorescence detection. 3. Unconjugated 1-hydroxypyrene can be detected in the urine of pigs followi...

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Veröffentlicht in:	Xenobiotica 1983-01, Vol.13 (7), p.415-420
Hauptverfasser:	Keimig, S. D., Kirby, K. W., Morgan, D. P., Keiser, J. E., Hubert, T. D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Chemical agents Chromatography, High Pressure Liquid Gas Chromatography-Mass Spectrometry Medical sciences Mutagens - metabolism Pyrenes - urine Spectrophotometry Swine Tumors
Online-Zugang:	Volltext
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