Functionally Selective Dopamine D2/D3 Receptor Agonists Comprising an Enyne Moiety

Dopaminergics of types 1 and 2 incorporating a conjugated enyne as an atypical catechol-simulating moiety were synthesized in enantiomerically pure form and investigated for their metabolic stability. Radioligand binding studies indicated high affinity to D2-like receptors. The test compounds were e...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of medicinal chemistry 2013-06, Vol.56 (12), p.5130-5141
Hauptverfasser:	Hiller, Christine, Kling, Ralf C, Heinemann, Frank W, Meyer, Karsten, Hübner, Harald, Gmeiner, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkenes - chemistry Alkynes - chemistry Alkynes - metabolism Alkynes - pharmacology Animals Dopamine Agonists - chemistry Dopamine Agonists - metabolism Dopamine Agonists - pharmacology Drug Stability Humans Ligands Male Models, Molecular Protein Conformation Rats Receptors, Dopamine D2 - agonists Receptors, Dopamine D2 - chemistry Receptors, Dopamine D3 - agonists Receptors, Dopamine D3 - chemistry Stereoisomerism Substrate Specificity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!