Compound Aggregation in Drug Discovery: Implementing a Practical NMR Assay for Medicinal Chemists

The pharmaceutical industry has recognized that many drug-like molecules can self-aggregate in aqueous media and have physicochemical properties that skew experimental results and decisions. Herein, we introduce the use of a simple NMR strategy for detecting the formation of aggregates using dilutio...

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Veröffentlicht in:	Journal of medicinal chemistry 2013-06, Vol.56 (12), p.5142-5150
Hauptverfasser:	LaPlante, Steven R, Carson, Rebekah, Gillard, James, Aubry, Norman, Coulombe, René, Bordeleau, Sylvain, Bonneau, Pierre, Little, Michael, O’Meara, Jeff, Beaulieu, Pierre L
Format:	Artikel
Sprache:	eng
Schlagworte:	Detergents - chemistry Drug Discovery - methods Magnetic Resonance Spectroscopy Pharmaceutical Preparations - chemistry Solubility
Online-Zugang:	Volltext
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