Design, Synthesis, and Initial Evaluation of a High Affinity Positron Emission Tomography Probe for Imaging Matrix Metalloproteinases 2 and 9

The activity of matrix metalloproteinases (MMPs) is elevated locally under many pathological conditions. Gelatinases MMP2 and MMP9 are of particular interest because of their implication in angiogenesis, cancer cell proliferation and metastasis, and atherosclerotic plaque rupture. The aim of this st...

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Veröffentlicht in:	Journal of medicinal chemistry 2013-06, Vol.56 (12), p.4912-4920
Hauptverfasser:	Selivanova, Svetlana V, Stellfeld, Timo, Heinrich, Tobias K, Müller, Adrienne, Krämer, Stefanie D, Schubiger, P. August, Schibli, Roger, Ametamey, Simon M, Vos, Bernhard, Meding, Jörg, Bauser, Marcus, Hütter, Joachim, Dinkelborg, Ludger M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chemistry Techniques, Synthetic Drug Design Fluorine Radioisotopes Humans Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - metabolism Matrix Metalloproteinase Inhibitors - chemical synthesis Matrix Metalloproteinase Inhibitors - chemistry Matrix Metalloproteinase Inhibitors - pharmacology Mice Mice, Inbred C57BL Multimodal Imaging - methods Positron-Emission Tomography Tomography, X-Ray Computed
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