Inhibition of Histone Demethylase JMJD1A Improves Anti-Angiogenic Therapy and Reduces Tumor-Associated Macrophages

Antiangiogenic strategies can be effective for cancer therapy, but like all therapies resistance poses a major clinical challenge. Hypoxia and nutrient starvation select for aggressive qualities that may render tumors resistant to antiangiogenic attack. Here, we show that hypoxia and nutrient starva...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2013-05, Vol.73 (10), p.3019-3028
Hauptverfasser:	OSAWA, Tsuyoshi, TSUCHIDA, Rika, MIYANO, Satoru, MINAMI, Takashi, KODAMA, Tatsuhiko, SHIBUYA, Masabumi, MURAMATSU, Masashi, SHIMAMURA, Teppei, FENG WANG, SUEHIRO, Jun-Ichi, KANKI, Yasuharu, WADA, Youichiro, YUASA, Yasuhito, ABURATANI, Hiroyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Inhibitors - therapeutic use Animals Antineoplastic agents Biological and medical sciences Cell Hypoxia Cell Line, Tumor Drug Resistance, Neoplasm Humans Jumonji Domain-Containing Histone Demethylases - antagonists & inhibitors Jumonji Domain-Containing Histone Demethylases - physiology Macrophages - drug effects Medical sciences Mice Mice, Inbred C57BL Neoplasms - blood supply Neoplasms - drug therapy Neoplasms - pathology Neovascularization, Pathologic - etiology Pharmacology. Drug treatments Receptors, Vascular Endothelial Growth Factor - antagonists & inhibitors Tumors Vascular Endothelial Growth Factor A - antagonists & inhibitors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!