Double Gold-Catalysed Annulation of Indoles by Enynones

Double Gold-Catalysed Annulation of Indoles by Enynones

The gold‐catalysed double functionalisation of indoles is presented. Enynones are used to annulate indoles via a double sodium tetrachloroaurate‐catalysed process involving a mixture of CH activation and alkyne activation modes of promotion. Good yields for the formation of medicinally relevant [6,...

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Veröffentlicht in:Advanced synthesis & catalysis 2013-04, Vol.355 (6), p.1149-1159
Hauptverfasser: Heffernan, Stephen J., Tellam, James P., Queru, Marine E., Silvanus, Andrew C., Benito, David, Mahon, Mary F., Hennessy, Alan J., Andrews, Benjamin I., Carbery, David R.
Format: Artikel
Sprache:eng
Schlagworte:
Activation
Alkynes
cascade reactions
Catalysis
diversity
gold
Indoles
Promotion
Sodium
Synthesis
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Zusammenfassung:The gold‐catalysed double functionalisation of indoles is presented. Enynones are used to annulate indoles via a double sodium tetrachloroaurate‐catalysed process involving a mixture of CH activation and alkyne activation modes of promotion. Good yields for the formation of medicinally relevant [6,5,7]‐tricyclic indoles are realised.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201300018