Expansion of cyclophosphamide-resistant cytotoxic precursors in vitro and in vivo by purified human interleukin 2
Precursors of cytotoxic lymphoid cells obtained from mice treated with cyclophosphamide (CY) can be expanded in culture by alloantigens in the presence of purified human interleukin 2 (IL 2). Similarly, IL 2 delivered in vivo in a rate-controlled manner enhances cytotoxic activity in mice that are i...
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| Veröffentlicht in: | The Journal of immunology (1950) 1983-08, Vol.131 (2), p.806-809 |
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| container_end_page | 809 |
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| container_issue | 2 |
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| container_title | The Journal of immunology (1950) |
| container_volume | 131 |
| creator | Merluzzi, VJ Welte, K Savage, DM Last-Barney, K Mertelsmann, R |
| description | Precursors of cytotoxic lymphoid cells obtained from mice treated with cyclophosphamide (CY) can be expanded in culture by alloantigens in the presence of purified human interleukin 2 (IL 2). Similarly, IL 2 delivered in vivo in a rate-controlled manner enhances cytotoxic activity in mice that are immunosuppressed by high doses of CY. The effector cells are Thy-1.2+ and are not elicited in the absence of antigen. |
| doi_str_mv | 10.4049/jimmunol.131.2.806 |
| format | Article |
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| ispartof | The Journal of immunology (1950), 1983-08, Vol.131 (2), p.806-809 |
| issn | 0022-1767 1550-6606 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Antigens, Surface - analysis Cyclophosphamide - pharmacology Drug Resistance Interleukin-2 - pharmacology Isoantigens - immunology Male Mice Mice, Inbred C57BL Mice, Inbred DBA T-Lymphocytes, Cytotoxic - drug effects T-Lymphocytes, Cytotoxic - immunology Thy-1 Antigens |
| title | Expansion of cyclophosphamide-resistant cytotoxic precursors in vitro and in vivo by purified human interleukin 2 |
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