Carcinogenesis and aging. II. Modifying effect of aging on metabolism of methyl(acetoxymethyl)nitrosamine and its interaction with DNA of various tissues in rats

Young (3 month-old) and old (14 month-old) female outbred rats received a single i.p. dose (13 mg/kg) of N-[14C]methyl-N-acetoxymethylnitrosamine ([14C]DMN-OAc, which, under these conditions, selectively induces intestinal tumours. Complete DMN-OAc breakdown occurred within 30 min in both young and...

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Veröffentlicht in:	Carcinogenesis (New York) 1983-08, Vol.4 (8), p.967-973
Hauptverfasser:	Likhachev, Alexei J., Ohshima, Hiroshi, Anisimov, Vladimir N., Ovsyannikov, Anton I., Revskoy, Sergei Yu, Keefer, Larry K., Reist, Elmer J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animals Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Carcinogens - toxicity Chemical agents Dimethylnitrosamine - analogs & derivatives Dimethylnitrosamine - metabolism Dimethylnitrosamine - toxicity DNA - metabolism Female Intestinal Mucosa - metabolism Liver - growth & development Liver - metabolism Lung - growth & development Lung - metabolism Medical sciences Methylation Rats Tumors Uterus - growth & development Uterus - metabolism
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